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排序方式: 共有132条查询结果,搜索用时 62 毫秒
51.
P. SRIRAMARAO S. NAGPAL B. S. SUBBA RAO OM PRAKASH P. V. SUBBA RAO 《Clinical and experimental allergy》1991,21(1):55-62
The airborne pollen of the South American weed, Parthenium hysterophorus (American feverfew), accidentally introduced into India was found to be responsible for severe allergic rhinitis. A random clinical survey conducted on 2035 residents of Bangalore city with the aid of questionnaires and skin tests revealed that 7.1% of the study population was suffering from allergic rhinitis due to exposure to Parthenium pollen. Skin-prick tests performed on 1294 clinic patients suffering from nasobronchial allergy during the past 4 years have also shown that 42.5% were sensitive to Parthenium pollen. IgE and IgG antibodies specific for Parthenium pollen allergens were demonstrable in the sera of Parthenium-sensitive rhinitis patients. The specificity of these antibodies to Parthenium allergens was established by ELISA. A 7- to 11-fold higher stimulation was observed when lymphocytes from two Parthenium-sensitive rhinitis patients were treated in vitro with Parthenium pollen extract. To our knowledge, nowhere in the world has such a high incidence of allergic rhinitis due to a single pollen ever been reported. 相似文献
52.
t(1;3)(p36;q21) in acute nonlymphocytic leukemia: a new cytogenetic- clinicopathologic association 总被引:3,自引:0,他引:3
A number of specific chromosomal abnormalities have been associated with distinctive clinical and/or morphological subtypes of acute nonlymphocytic leukemia (ANLL) in recent years. We have studied three patients with ANLL and t(1;3)(p36;q21). Each had weakness as their major complaint, a moderately severe anemia and, for ANLL, a relatively high platelet count. All three demonstrated abnormalities of the megakaryocytic, erythroid and granulocytic lineages. Most striking was the dysmegakaryocytopoiesis. The blasts in all three patients showed relatively few azurophilic granules, one to four prominent nucleoli, and rare peroxidase positivity. No patient had Auer rods. No patient responded to standard chemotherapy regimens. The data suggest that t(1;3)(p36;q21) identifies a new cytogenetic-clinicopathologic subtype of ANLL. 相似文献
53.
Effects of nimodipine on cerebral blood flow and cerebrospinal fluid pressure after cardiac arrest: correlation with neurologic outcome 总被引:1,自引:0,他引:1
Fifty-one patients were included in a blind randomized study to evaluate whether the Ca-blocker nimodipine could influence cerebral blood flow (CBF) or cerebrospinal fluid pressure (CSFP) during the cerebral hypoperfusion period that follows resuscitation from cardiac arrest and to determine whether changes in CBF correlate with neurologic outcome. CBF measured 1 to 4 hours after arrest with the use of 133Xe intravenous was significantly greater with nimodipine than with placebo (27 +/- 3 versus 13 +/- 1 ml.100 g-1.min-1 at 3 hours), but with no significant difference at 24 hours. There was no clinical evidence of seriously increased CSFP in any patient in either group the first 48 hours. Mean arterial pressure was significantly lower (86 +/- 4 versus 101 +/- 4 mm Hg at 3 hours), and antiarrhythmic drugs were used significantly less frequently in the nimodipine group than in the placebo group. Twelve patients in each group eventually regained consciousness. There was no significant difference in neurologic status between the two groups at any point, and no positive correlation between CBF in the hypoperfusion period and neurologic outcome. 相似文献
54.
55.
Foncuberta MC Cagnoni PJ Brandts CH Mandanas R Fields K Derigs HG Reed E Sonis ST Fay J LeVeque F Pouillart P Schrezenmeier H Emmons R Thiel E;Investigators in TGF-beta/OM Study Protocols / 《Journal of immunotherapy (Hagerstown, Md. : 1997)》2001,24(4):384-388
Transforming growth factor (TGF)-beta3 has been hypothesized to prevent or alleviate oral mucositis (OM) in cancer patients receiving high-dose chemotherapy (CT). Two double-blind, placebo-controlled, multicenter, phase II studies of TGF-beta3 were initiated in the United States, Europe, and Argentina in patients with lymphomas or solid tumors who were receiving highly stomatotoxic CT regimens. Patients were to apply 10-mL mouthwash applications of TGF-beta3 (25 microg/mL) or placebo four times daily (or twice daily) 1 day before and all days during CT. The patients were subsequently evaluated for OM incidence, severity, and duration using National Institute of Cancer Common Toxicity Criteria (NCI-CTC) criteria and an objective scoring system (1). After the start of the trials, negative results from new preclinical studies suggesting suboptimal formulation and/or dosing led to an interim analysis of the ongoing clinical trials. One hundred fifty-two patients from the combined studies were included in the interim analysis, with 116 patients on the TGF-beta3 four times daily and placebo arms. Most (72%) patients had breast cancer, 22% had lymphomas, and 6% had other solid tumors. Although 98% (149 of 152) of patients experienced adverse events, only 14% (22 of 152) experienced events that were judged as possibly or probably related to the study drug (primarily gastrointestinal symptoms). No clinically relevant differences were seen between the treatment and placebo arms regarding safety, nor was there evidence for systemic absorption of TGF-beta3. Finally, there was no advantage of TGF-beta3 treatment regarding the incidence (TGF-beta3 four times daily versus placebo [46% versus 47%]), onset, or duration of NCI-CTC grade 3 or 4 OM. For this dose, formulation, regimen. and patient population, TGF-beta3 was not effective in the prevention or alleviation of CT-induced OM. 相似文献
56.
Emil K. S. Espe Jan Magnus Aronsen Biljana Skrbic Vidar Magne Skulberg Jürgen E. Schneider Ole M. Sejersted Lili Zhang Ivar Sjaastad 《Magnetic resonance in medicine》2013,69(1):48-61
Phase‐contrast MRI (PC‐MRI) velocimetry is a noninvasive, high‐resolution motion assessment tool. However, high motion sensitivity requires strong motion‐encoding magnetic gradients, making phase‐contrast‐MRI prone to baseline shift artifacts due to the generation of eddy currents. In this study, we propose a novel nine‐point balanced velocity‐encoding strategy, designed to be more accurate in the presence of strong and rapidly changing gradients. The proposed method was validated using a rotating phantom, and its robustness and precision were explored and compared with established approaches through computer simulations and in vivo experiments. Computer simulations yielded a 39–57% improvement in velocity–noise ratio (corresponding to a 27–33% reduction in measurement error), depending on which method was used for comparison. Moreover, in vivo experiments confirmed this by demonstrating a 26–53% reduction in accumulated velocity error over the R–R interval. The nine‐point balanced phase‐contrast‐MRI‐encoding strategy is likely useful for settings where high spatial and temporal resolution and/or high motion sensitivity is required, such as in high‐resolution rodent myocardial tissue phase mapping. Magn Reson Med, 2013. © 2012 Wiley Periodicals, Inc. 相似文献
57.
FRANCISCO P. QUISMORIO JR OM P. SHARMA† STEBBINS CHANDOR‡ 《The British journal of dermatology》1977,97(6):635-642
We examined the immunohistology of the cutaneous granulomas in sarcoidosis. By direct immunofluorescence immunoglobulin deposits were found in the skin lesions of 5 to 8 patients. These consisted of IgM within blood vessel wall (5 patients), IgM at the epidermal-dermal junction (2 patients) and IgG within and around the granuloma (2 patients). A fibrin network was present within the granulomas. Biopsy of a Kveim test site but not of uninvolved skin or of an erythema nodosum lesion showed similar immunofluorescence findings. Sheep erythrocytes sensitized with IgG antibody adhered to epithelioid cells within the granuloma indicating the presence of surface Fc receptors. At the periphery of the granulomas were B-lymphocytes. These findings are similar to those described in nodal and pulmonary sarcoid granulomas, and suggest that humoral antibodies may be important in the pathogenesis of the sarcoid granuloma. 相似文献
58.
Structural characterization of toxic cyclic peptides from blue-green algae by tandem mass spectrometry. 总被引:10,自引:0,他引:10
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T Krishnamurthy L Szafraniec D F Hunt J Shabanowitz J R Yates rd C R Hauer W W Carmichael O Skulberg G A Codd S Missler 《Proceedings of the National Academy of Sciences of the United States of America》1989,86(3):770-774
Combined use of chemical degradation, derivatization, and tandem mass spectrometry for rapid structural characterization of toxic cyclic peptides from blue-green algae at the nanomole level is described. Previously, all blue-green algal toxins were thought to belong to a family of seven-residue cyclic peptides, having the general structure cyclo-D-Ala-L-Xaa-erythro-beta-methyl-D-isoaspartic acid-L-Yaa-Adda-D-isoglutamic acid-N-methyldehydroalanine, where Xaa and Yaa represent variable amino acids of the L configuration and Adda is 3-amino-9-methoxy-2,6,8-trimethyl-10-phenyl-deca-4,6-dienoic acid. Structural characterization of two additional toxins indicates that further variability can exist within this family of naturally occurring toxic cyclic peptides. Isoaspartic acid and dehydroalanine can substitute for beta-methylisoaspartic acid and N-methyldehydroalanine, respectively. 相似文献
59.
Is the male involved in the aetiology of ectopic pregnancy? 总被引:3,自引:0,他引:3
Warnes GM; Petrucco OM; Seamark RF; Lancaster PA 《Human reproduction (Oxford, England)》1998,13(12):3505-3510
We have previously observed a low incidence of ectopic pregnancies in
couples having gamete intra-Fallopian transfer (GIFT) with donated
spermatozoa. Based on findings in both animal and human models, we proposed
the hypothesis that sperm defects may be associated with the expression of
paternal genes which cause abnormal early embryo development and predispose
the embryos to interact inappropriately with the genital tract epithelium,
and so increase the risk of an ectopic implantation. To both confirm and
extend the initial observation, GIFT and in-vitro fertilization (IVF)
pregnancies entered on the Australian and New Zealand national database
between 1979 and 1993 were analysed with regard to the incidence of ectopic
pregnancy. There was an increased risk of ectopic pregnancy for IVF
relative to GIFT and when spermatozoa from the male partner were used
rather than donor spermatozoa. However, when couples were categorized with
respect to the aetiology of their infertility, we were unable to show a
significant association between ectopic pregnancy and whether spermatozoa
from the male partner or a donor were used. We have therefore been unable
to confirm a direct association between the source of spermatozoa and
ectopic pregnancy.
相似文献
60.
Seventy-five spot compression views of equivocally suspicious lesions detected at routine mammographic examination of 72 women were reviewed in this retrospective study. Sixty-five of the 75 lesions appeared less suspicious on spot compression views, two did not change, and eight appeared more suspicious. Biopsy findings confirmed that the eight more suspicious lesions were cancer. The adjunctive use of spot compression helped characterize equivocal findings seen on routine mammographic views and improved the accuracy of mammographic interpretation. 相似文献