An unusual neuroimaging finding and response to immunotherapy in a child with genetically confirmed vanishing white matter disease

Background

We present an unusual neuroimaging finding in a young girl with genetically confirmed vanishing white matter disease and a possible response to immunotherapy.

Oleanderoic Acid and Oleanderen from the Leaves of Nerium oleander

A new labdane diterpene, oleanderoic acid and a new triterpene, oleanderen have been isolated from the fresh, undried and uncrushed leaves of NERIUM OLEANDER. Their structures have been established as 8alpha-methoxylabdan-18-oic acid, and 12-ursene, respectively, through chemical and spectral studies, including 2D-NMR (COSY-45, NOESY and 2D- J resolved) and (13)C-NMR data.     

A New Alkaloid Ajmalimine from the Roots of Rauwolfia serpentina

A new indole alkaloid ajmalimine has been isolated from the roots of RAUWOLFIA SERPENTINA collected in Thailand. Its structure, 21-(trimethoxybenzoyl)-ajmaline, was established by spectroscopic and chemical means.     

Isolation and Structure of Neriucoumaric and Isoneriucoumaric Acids from the Leaves of Nerium oleander

Two new coumaryloxy triterpenoids, neriucoumaric and isoneriucoumaric acids, have been isolated from fresh, undried and uncrushed leaves of NERIUM OLEANDER and their structures established as 3beta-hydroxy-2alpha-cis- P-coumaryloxy-urs-12-en-28-oic acid and 3beta-hydroxy-2alpha- TRANS- P-coumaryloxy-urs-12-en-28-oic acid respectively, through chemical and spectroscopic methods.     

Tricyclic Diterpenes from the Stem Bark of Azadirachta indica

Two new diterpenoids, margosone and margosolone, have been isolated from the stem bark of AZADIRACHTA INDICA A. Juss (neem) and their structures established as 12,13-dihydroxy-14-isoporpylpodocarpa-8,11,13-trien-7-one and 13-hydroxy-12-methoxypodocarpa-8,11,13-trien-7-one, respectively, through chemical and spectroscopic studies.