Deterioration of MRI findings related to Jarisch–Herxheimer reaction in a patient with neurosyphilis

Journal of Neurology -     

Disseminated calcifying tumor of the pleura: review of the literature and a case report with immunohistochemical study of its histogenesis

Calcifying tumor of the pleura is a rare benign tumor, similar to the calcifying fibrous pseudotumor originally described in the subcutaneous and deep soft tissues of the extremities, trunk, and neck. Calcifying tumors of the pleura have also been reported infrequently as disseminated lesions. Here we report a case of disseminated calcifying tumor of the pleura, with some new findings obtained in this study, and review the literature of disseminated calcifying tumor of the pleura.     

Transcatheter aortic valve implantation: first trans-iliac experience in Japan

Conventional aortic valve replacement (AVR) is the gold standard surgical treatment for symptomatic aortic valve stenosis. However, some patients are not referred for open surgical procedure because of their high risk due to complicated co-morbidities. We describe the first case in Japan of successful transcatheter aortic valve implantation (TAVI). An 81-year-old woman with severe interstitial pneumonia was referred for significant aortic valve stenosis. Conventional AVR might have been risky, so TAVI was planned after informed consent was obtained. Under general anesthesia was established, a 23-mm Edwards SAPIEN transcatheter heart valve was implanted through the common iliac artery. Postoperative echocardiographic assessment showed satisfactory hemodynamic function with a stable valve position, and she was discharged on day 7 without complications. At the 6-month follow-up, there had been no untoward events, and there was marked improvement in her functional status. TAVI for symptomatic aortic valve stenosis is a less invasive, alternative approach for high-risk patients.     

Cytopathologic characteristics and differential diagnostic considerations of neuroglial heterotopia of the retropharyngeal space

Neuroglial heterotopias (NGH) are rare congenital head and neck lesions composed of differentiated neuroectodermal tissue and representing developmental heterotopias rather than true neoplasms. The case of a male neonate with respiratory distress and early feeding problems depicting a retropharyngeal space mass which in the intraoperative squash smears revealed glial cells with multiple cytoplasmic processes is reported here. Small clusters of cuboidal epithelial cells with rosette-like ependymal structures and cuboidal cells arranged in sheets or branching folds suggestive of choroid plexus cells were also identified. Through this cytological approach a cytologic diagnosis of a NGH or low-grade astrocytoma was suggested. Further evaluation and immunohistochemical studies were conducted on formalin-fixed, paraffin-embedded material. Glial cells, ependymal structures and choroid plexus were identified on H&E sections. Immunohistochemically, the glial cells showed diffuse and strong cytoplasmic staining for glial fibrillary acidic protein (GFAP) and S-100 protein and focal immunoreactivity for synaptophysin and neurofilament. The proliferative index with MIB-1 was around 4%. The diagnosis of NGH of the retropharyngeal space was confirmed based on the clinical, cytopathologic, histopathology, immunohistochemical results, and the location of the tumor. We demonstrated here for the first time the cytopathological features of NGH of the retropharyngeal space with emphasis on differential diagnostic considerations.