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排序方式: 共有6249条查询结果,搜索用时 109 毫秒
171.
Fa‐Po Chung Ying‐Chieh Liao Yenn‐Jiang Lin Shih‐Lin Chang Li‐Wei Lo Yu‐Feng Hu Ta‐Chuan Tuan Tze‐Fan Chao Jo‐Nan Liao Chin‐Yu Lin Ting‐Yung Chang Jennifer Jeanne B. Vicera Chye‐Gen Chin Cheng‐I Wu Chih‐Min Liu Po‐Tseng Lee Ting‐Chun Huang Isaiah C. Lugtu Shih‐Ann Chen 《Journal of cardiovascular electrophysiology》2020,31(1):9-17
172.
Jennifer Jeanne B. Vicera Yenn‐Jiang Lin Po‐Tseng Lee Shih‐Lin Chang Li‐Wei Lo Yu‐Feng Hu Fa‐Po Chung Chin‐Yu Lin Ting‐Yung Chang Ta‐Chuan Tuan Tze‐Fan Chao Jo‐Nan Liao Cheng‐I Wu Chih‐Min Liu Chung‐Hsing Lin Chieh‐Mao Chuang Chun‐Chao Chen Chye Gen Chin Shin‐Huei Liu Wen‐Han Cheng Le Phat Tai Sung‐Hao Huang Ching‐Yao Chou Isaiah Lugtu Ching‐Han Liu Shih‐Ann Chen 《Journal of cardiovascular electrophysiology》2020,31(6):1436-1447
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175.
Prashant Sonar Tae‐Jun Ha Yuri Seong Shih‐Chieh Yeh Chin‐Ti Chen Sergei Manzhos Ananth Dodabalapur 《Macromolecular chemistry and physics.》2014,215(8):725-732
A fused aromatic furan‐substituted diketopyrrolopyrrole and novel diphenylfumaronitrile conjugated building blocks are used for the synthesis of an alternating copolymer ( DPFN‐DPPF ) via Suzuki polycondensation. In this paper, the first attempt to use the diphenylfumaronitrile building block for the synthesis of conjugated polymer is described. The number‐average and weight‐average molecular weights calculated for DPFN‐DPPF are 20 661 and 66 346 g mol?1, respectively. The optical bandgap calculated for DPFN‐DPPF is 1.53 eV whereas the highest occupied molecular orbital (HOMO) value calculated by photoelectron spectroscopy in air (PESA) is 5.50 eV. The calculated HOMO value is lower, which is suitable for stable organic electronic devices. DPFN‐DPPF polymer is used as an active layer in bottom‐contact bottom‐gate organic thin‐film transistor devices and the thin film exhibits a hole mobility of 0.20 cm2 V?1 s?1 in air.
176.
Yang-Sheng Lin Ming-Jen Chen Shou-Chuan Shih Ming-Joug Bair Ching-Ju Fang Horng-Yuan Wang 《World journal of gastroenterology : WJG》2014,20(18):5274-5282
The Maastricht IV/Florence Consensus Report and the Second Asia-Pacific Consensus Guidelines strongly recommend eradication of Helicobacter pylori(H.pylori)in patients with previous gastric neoplasia who have undergone gastric surgery.However,the guidelines do not mention optimal timing,eradication regimens,diagnostic tools,and follow-up strategies for patients undergoing gastrectomy and do not indicate if eradication of H.pylori reduces the risk of marginal ulcer or stump cancer in the residual stomach after gastrectomy.The purpose of this review is to provide an update which may help physicians to properly manage H.pylori infection in patients who have undergone gastric surgery.This review focuses on(1)the microenvironment change in the stomach after gastrectomy;(2)the phenomenon of spontaneous clearance of H.pylori after gastrectomy;(3)the effects of H.pylori on gastric atrophy and intestinal metaplasia after gastrectomy;(4)incidence and clinical features of ulcers developing after gastrectomy;(5)does eradication of H.pylori reduce the risk of gastric stump cancer in the residual stomach?(6)does eradication of H.pylori reduce the risk of secondary metachronous gastric cancer in the residual stomach?and(7)optimal timing and regimens for H.pylori eradication,diagnostic tools and follow-up strategies for patients undergoing gastrectomy. 相似文献
177.
Pei‐Chi Chen Su‐Kiat Chua Huei‐Fong Hung Chung‐Yen Huang Chiu‐Mei Lin Shih‐Ming Lai Yen‐Ling Chen Jun‐Jack Cheng Chiung‐Zuan Chiu Shih‐Huang Lee Huey‐Ming Lo Kou‐Gi Shyu 《Journal of diabetes investigation.》2014,5(1):80-86
Aims/Introduction
Admission hyperglycemia is associated with poor outcome in patients with myocardial infarction. The present study evaluated the relationship between admission glucose level and other clinical variables in patients with ST‐elevation myocardial infarction (STEMI) undergoing primary percutaneous coronary intervention (PCI).Materials and Methods
The 959 consecutive STEMI patients undergoing primary PCI were divided into five groups based on admission glucose levels of <100, 100–139, 140–189, 190–249 and ≥250 mg/dL. Their short‐ and long‐term outcomes were compared.Results
Higher admission glucose levels were associated with significantly higher in‐hospital morbidity and mortality, the overall mortality rate at follow up, and the incidence of reinfarction or heart failure requiring admission or leading to mortality at follow up. The odds ratios (95% confidence interval) for in‐hospital morbidity, in‐hospital mortality, mortality at follow up and re‐infarction or heart failure or mortality at follow up of patients with admission glucose levels ≥190 mg/dL, compared with those with admission glucose levels <190 mg/dL, were 2.12 (1.3–3.4, P = 0.001), 2.74 (1.4–5.5, P = 0.004), 2.52 (1.2–5.1, P = 0.01) and 1.70 (1.03–2.8, P = 0.04), respectively. Previously non‐diabetic patients with admission glucose levels ≥250 mg/dL had significantly higher in‐hospital morbidity or mortality (44 vs 70%, P = 0.03). Known diabetic patients had higher rates of reinfarction, heart failure or mortality at follow up in the 100–139 mg/dL (8 vs 27%, P = 0.04) and 140–189 mg/dL (11 vs 26%, P = 0.02) groups.Conclusions
Admission hyperglycemia, especially at glucose levels ≥190 mg/dL, is a predictor of poor prognosis in STEMI patients undergoing primary PCI. 相似文献178.
179.
Priscilla Mantik Minli Xie Harvey Wong Hank La Ronald W. Steigerwalt Uday Devanaboyina Geoffrey Ganem Danny Shih John A. Flygare Wayne J. Fairbrother Paroma Chakravarty David Russell Gilberto E. Fernandez Ajit S. Narang 《Journal of pharmaceutical sciences》2019,108(6):1934-1943
Solubilization of new chemical entities for toxicity assessment must use excipients that do not negatively impact drug pharmacokinetics and toxicology. In this study, we investigated the tolerability of a model freebase compound, GDC-0152, solubilized by pH adjustment with succinic acid and complexation with hydroxypropyl-β-cyclodextrin (HP-β-CD) to enable intravenous use. Solubility, critical micelle concentration, and association constant with HP-β-CD were determined. Blood compatibility and potential for hemolysis were assessed in vitro. Local tolerability was assessed after intravenous and subcutaneous injections in rats. A pharmacokinetic study was conducted in rats after intravenous bolus administration.GDC-0152 exhibited pH-dependent solubility that was influenced by self-association. The presence of succinic acid increased solubility in a concentration-dependent manner. HP-β-CD alone also increased solubility, but the extent of solubility enhancement was significantly lower than succinic acid alone. Inclusion of HP-β-CD in the solution of GDC-0152 improved blood compatibility, reduced hemolytic potential by ~20-fold in vitro, and increased the maximum tolerated dose to 80 mg/kg. 相似文献
180.