全文获取类型
收费全文 | 22199篇 |
免费 | 2185篇 |
国内免费 | 1891篇 |
专业分类
耳鼻咽喉 | 156篇 |
儿科学 | 181篇 |
妇产科学 | 280篇 |
基础医学 | 2805篇 |
口腔科学 | 247篇 |
临床医学 | 3117篇 |
内科学 | 3158篇 |
皮肤病学 | 198篇 |
神经病学 | 1278篇 |
特种医学 | 859篇 |
外国民族医学 | 13篇 |
外科学 | 2094篇 |
综合类 | 3760篇 |
现状与发展 | 5篇 |
一般理论 | 1篇 |
预防医学 | 1526篇 |
眼科学 | 656篇 |
药学 | 2564篇 |
29篇 | |
中国医学 | 1563篇 |
肿瘤学 | 1785篇 |
出版年
2024年 | 73篇 |
2023年 | 399篇 |
2022年 | 980篇 |
2021年 | 1221篇 |
2020年 | 973篇 |
2019年 | 741篇 |
2018年 | 772篇 |
2017年 | 775篇 |
2016年 | 728篇 |
2015年 | 1092篇 |
2014年 | 1349篇 |
2013年 | 1158篇 |
2012年 | 1626篇 |
2011年 | 1946篇 |
2010年 | 1186篇 |
2009年 | 1006篇 |
2008年 | 1183篇 |
2007年 | 1155篇 |
2006年 | 1142篇 |
2005年 | 1155篇 |
2004年 | 730篇 |
2003年 | 704篇 |
2002年 | 561篇 |
2001年 | 486篇 |
2000年 | 511篇 |
1999年 | 525篇 |
1998年 | 311篇 |
1997年 | 323篇 |
1996年 | 247篇 |
1995年 | 243篇 |
1994年 | 204篇 |
1993年 | 120篇 |
1992年 | 133篇 |
1991年 | 91篇 |
1990年 | 95篇 |
1989年 | 79篇 |
1988年 | 70篇 |
1987年 | 68篇 |
1986年 | 53篇 |
1985年 | 25篇 |
1984年 | 9篇 |
1983年 | 8篇 |
1982年 | 7篇 |
1981年 | 5篇 |
1980年 | 2篇 |
1979年 | 5篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
991.
The spinel structure Zn1.8Co0.2TiO4 single crystals with 5 mm diameter and 30 mm length were successfully grown by an optical floating zone method. The as-grown crystals were characterized by X-ray diffraction (XRD), Raman and X-ray photoelectron spectroscopy (XPS). Some Zn2+ ions at tetrahedral and octahedral sites should be replaced by doped transition metal Co2+ ions. The temperature-dependent Raman spectra of spinel Zn1.8Co0.2TiO4 crystals were also described. The optical phonon behaviors of Zn1.8Co0.2TiO4 are stable within the temperature range. The magnetic properties of Zn1.8Co0.2TiO4 were investigated by using Physical Property Measurement System.The spinel structure Zn1.8Co0.2TiO4 single crystals with 5 mm diameter and 30 mm length were successfully grown by an optical floating zone method. 相似文献
992.
Cui Bixiao Zhang Tianhao Ma Yan Chen Zhongwei Ma Jie Ma Lei Jiao Liqun Zhou Yun Shan Baoci Lu Jie 《European journal of nuclear medicine and molecular imaging》2020,47(7):1668-1677
European Journal of Nuclear Medicine and Molecular Imaging - Cerebral blood flow (CBF) and glucose metabolism are important and significant factors in ischaemic cerebrovascular disease. The... 相似文献
993.
994.
Clinical Rheumatology - Our study aimed to investigate the effect of illness uncertainty on sleep quality among SLE women. Meanwhile, the role of resilience was explored in the association of... 相似文献
995.
Although most current studies have established the importance of school‐related parental involvement to adolescents' academic achievement, they are limited in that they do not address macrolevel community influences on such an association. This may be due in part to the lack of community‐level data or the use of inappropriate statistical strategies that cannot account for the influence of factors at the community level. To address this limitation, in this study, the authors examined the influence of community poverty on the association between school‐related parental involvement and adolescents' academic achievement. Using a large, nationally representative sample, results from a multilevel model suggested that, compared to adolescents living in more affluent communities, the positive effect of school‐related parental involvement on adolescents' academic achievement was significantly weaker for adolescents living in poor communities. Such findings suggested the importance of community poverty in influencing the effectiveness of school‐related parental involvement on adolescents' academic achievement. 相似文献
996.
Pulmonary mycosis can be seen in previously healthy individuals after submersion or near-drowning. We present two cases of the disease confirmed with histological examination in immuno-competent patients after near-drowning incidents. The submersion event in contaminated water likely increases the risk of pulmonary mycosis .Monitoring in the intensive care unit, along with the use of corticosteroids and antibiotics could have rendered our patients more vulnerable to mycosis. The definite diagnosis relies on etiological identification by fungal culture and histopathological evidence, and it may be difficult because of the lack of etiological identification. Therefore, clinical diagnosis relies on the association of a host factor, clinical course, radiological findings and microbiological findings. While optimal treatment remains undefined, the empirical early use of voriconazole has been proposed in cases of suspected scedosporiosis after near-drowning or even prophylactically in all near-drowning patients. Application of broad spectrum antifungal drugs and close monitoring for side effects are the most important contributors to favorable outcome. 相似文献
997.
Hsieh Evelyn Fraenkel Liana Bradley Elizabeth H. Xia Weibo Insogna Karl L. Cui Qu Li Kunli Li Taisheng 《Archives of osteoporosis》2014,9(1):1-10
Summary
The worldwide uptake of FRAX is described.Introduction
The aim of this report was to determine the usage of FRAX worldwide over a 1-year period from 1 May 2012.Methods
The number of FRAX calculations from each country was assessed over a 1-year period and expressed as calculations per million of the population aged 50 years or more. Countries were colour coded according to usage to populate a world map.Results
Over the index year, there were estimated to be 2,391,639 calculations sourced from 173 counties. Uptake was high in North America, the Antipodes and most countries of Europe; intermediate in Latin America and the Middle East; and very low in Africa and much of South East Asia.Conclusions
It is expected that the comparative data will encourage the development of new FRAX models and the uptake of FRAX into assessment guidelines. 相似文献998.
Hua Zhao Lei Cheng Yi Liu Wen Zhang Sailendra Maharjan Zhaoqiang Cui Xingli Wang Dongqi Tang Lin Nie 《Journal of molecular neuroscience : MN》2014,52(2):186-192
Microglia are important resident immune cells in the central nervous system (CNS) and involved in the neuroinflammation caused by CNS disorders, including brain trauma, ischemia, stroke, infections, inflammation, and neurodegenerative diseases. Our study explores the hypothesis that conserved dopamine neurotrophic factor (CDNF), a secretory neurotrophic factor, may provide a novel therapy for associated with neuroinflammation related to the microglia. We observed that CDNF was upregulated in rat primary microglia treated with 1 μg/mL lipopolysaccharide, an inflammatory inducer, for 24 h. Thus, we hypothesize that CDNF may play a role, mediator or inhibitor, in regulating the inflammation in microglial cells induced by LPS. Finally, our data showed that CDNF significantly attenuated the production of proinflammatory cytokines (PGE2 and IL-1β) and remarkably alleviated the cytotoxicity (percentage of lactate dehydrogenase released) in the LPS-induced microglia by suppressing the phosphorylation of JNK, but not the P38 or ERK pathways. These results demonstrate the anti-inflammatory property of CDNF by inhibition of JNK signaling in LPS-induced microglia, suggesting that CDNF may be a potential novel agent for the treatment of neuroinflammation in the CNS disorders. 相似文献
999.
Dynamics of ten‐eleven translocation hydroxylase family proteins and 5‐hydroxymethylcytosine in oligodendrocyte differentiation
下载免费PDF全文
![点击此处可从《Glia》网站下载免费的PDF全文](/ch/ext_images/free.gif)
The ten‐eleven translocation (TET) family of methylcytosine dioxygenases catalyze oxidation of 5‐methylcytosine (5mC) to 5‐hydroxymethylcytosine (5hmC) and promote DNA demethylation. Despite the abundance of 5hmC and TET proteins in the brain, little is known about their role in oligodendrocytes (OLs). Here, we analyzed TET expression during OL development in vivo and in vitro, and found that three TET family members possess unique subcellular and temporal expression patterns. Furthermore, the level of 5hmC exhibits dynamic changes during OL maturation, which implies that 5hmC modification may play a role in the expression of critical genes necessary for OL maturation. siRNA‐mediated silencing of the TET family proteins in OLs demonstrated that each of the TET proteins is required for OL differentiation. However, based on their unique domain structures, we speculate that the three TET members may function by different mechanisms. In summary, we have established the temporal expression of TET proteins and the dynamic level of 5hmC during OL development and demonstrate that all three TET members are necessary for OL differentiation. GLIA 2014;62:914–926 相似文献
1000.
Shinghung Mak Wilson W. K. Luk Wei Cui Shengquan Hu Karl W. K. Tsim Yifan Han 《Journal of molecular neuroscience : MN》2014,53(3):511-516
Alzheimer’s disease is a multi-factorial neurodegenerative disorder devastatingly affecting the aged population worldwide. Previous studies have shown that medicinal herbs used in traditional Chinese medicine might be benefit to Alzheimer’s disease patients. Berberine and palmatine, two isoquinoline alkaloids found in several medicinal herbs, were used for memory enhancement in China. In this study, the inhibitory effects of combined berberine and palmatine on acetylcholinesteras were evaluated using recombinant human acetylcholinesterase. Our results showed that the combination of berberine and palmatine inhibited acetylcholinesterase in a mixed competitive pattern. By the median-effect principle, the calculated combination index of the combination was less than 1, suggesting that berberine and plamatine inhibited acetylcholinesterase synergistically. Furthermore, the drug-reducing index of berberine and palmatine were 2.98 and 2.66, respectively. Taken together, the results showed that the combination of the two alkaloids might potentially be developed as a more effective therapeutic strategy for Alzheimer’s disease patients. 相似文献