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101.
The effects of two calcium channel blockers (verapamil and cinnarizine) were evaluated on diazepam withdrawal symptoms. Rats were made diazepam dependent by chronic treatment with daily injections of the drug, 20 mg/kg IP for 3 weeks. On abrupt termination of the drug, animals showed withdrawal hyperactivity that was assessed by autonomic, behavioural and motor signs. The peak effect was seen 3 days after the withdrawal of diazepam. On IP administration, verapamil and cinnarizine (10, 20 and 40 mg/kg) given on eight occasions at an interval of 12 h reversed the withdrawal-induced increase in spontaneous motor activity. Cinnarizine in higher doses (20 and 40 mg/kg) was found to be effective in suppressing the behavioural signs but verapamil did not show any protective effect against startle response and irritability. These results suggest that modulation of the calcium influx in the CNS might influence withdrawal.This study was presented in XIth International Congress of Pharmacology (IUPHAR) at Amsterdam (July 1–6, 1990) 相似文献
102.
Are intravenous corticosteroids required in status asthmaticus? 总被引:2,自引:0,他引:2
Seventy-seven patients with status asthmaticus were prospectively studied to compare oral with intravenous methylprednisolone. Patients were given methylprednisolone, either 160 or 320 mg orally or 500 or 1000 mg intravenously, daily in equally divided doses. They were randomly assigned to either group on a daily sequential basis. Spirometry was performed within one hour of the initial dose of steroids. The mean presenting forced expiratory volume in 1 s was 26% of the predicted value. Spirometry was then repeated every six hours for the first 24 hours and then every eight to 12 hours until discharge or 72 hours, whichever occurred first. There were no significant differences in the incidence of respiratory failure, forced expiratory volume in 1 s, days of hospitalization, rate of improvement in pulmonary function, or side effects. No patient who went into respiratory failure did so more than three hours after receiving the initial dose of steroids. We conclude that oral methylprednisolone is safe and effective in the treatment of status asthmaticus. 相似文献
103.
S. Kumar N. H. Dar M. Ashraf S. C. Sharma V. Maheshwari 《Indian journal of otolaryngology and head and neck surgery》2004,56(1):37-39
We report a cast of ossifying fibroma of the nose, arising from the bony septum and extending into the nasophaynx in a 2 yrs.
old child presenting with features of obstructed nose. 相似文献
104.
105.
P A Brennan M C Bater S Sharma R S Oeppen 《Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics》2005,100(1):e9-10
Although lipomas are relatively common and found in most anatomical sites, we are not aware of any previous reports of lipomas arising between the two layers of the deep temporal fascia above the zygomatic arch. This is surprising because a fat pad is seen and used during surgery in this area to protect the frontal branch of the facial nerve. This case highlights the importance of understanding the anatomy of this region, because lipomas can potentially arise in any of three fat pads laying near the facial nerve in this area. 相似文献
106.
A male patient of 60 years presented with a swelling in the left groin of 10 months duration. Past records showed bilateral
lumbar sympathectomy and omentopexy done 20 and 6 years back, respectively, for Buerger’s disease. Abdominal examination revealed
a huge hernial swelling in the left groin extending from the symphysis pubis to anterior superior iliac spine measuring 25 × 18 cm.
On exploration, the contents were intestines and omentum, which were coming out through a defect of 5 × 3 cm in the lower
fibers of the conjoint muscle 4 cm cephalad to the deep ring, a finding which made the final diagnosis as an incisional hernia.
We present this interesting case as a very rare complication of omentopexy, probably not reported previously, and an unusual
case of an incisional hernia presenting as an inguinal hernia which is very difficult to diagnose unless encountered before.
Its rarity and clinical challenge is highlighted. 相似文献
107.
Mihir Prakash Pandia Parmod Kumar Bithal Hemant Bhagat Munish Sharma 《Journal of clinical neuroscience》2007,14(11):1139-1141
We report respiratory obstruction following surgery in the sitting position with tracheal intubation and placement of a transesophageal echocardiography probe. Obstruction was due to pharyngeal oedema, which resolved with 24 hours. The mechanisms of this complication are discussed. 相似文献
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