首页 | 本学科首页   官方微博 | 高级检索  
文章检索
  按 检索   检索词:      
出版年份:   被引次数:   他引次数: 提示:输入*表示无穷大
  收费全文   1761篇
  免费   97篇
  国内免费   10篇
耳鼻咽喉   44篇
儿科学   27篇
妇产科学   58篇
基础医学   195篇
口腔科学   87篇
临床医学   144篇
内科学   388篇
皮肤病学   22篇
神经病学   100篇
特种医学   59篇
外科学   323篇
综合类   32篇
一般理论   1篇
预防医学   103篇
眼科学   28篇
药学   103篇
中国医学   6篇
肿瘤学   148篇
  2024年   3篇
  2023年   26篇
  2022年   58篇
  2021年   108篇
  2020年   59篇
  2019年   83篇
  2018年   114篇
  2017年   60篇
  2016年   68篇
  2015年   65篇
  2014年   87篇
  2013年   110篇
  2012年   163篇
  2011年   169篇
  2010年   95篇
  2009年   76篇
  2008年   90篇
  2007年   81篇
  2006年   85篇
  2005年   72篇
  2004年   46篇
  2003年   41篇
  2002年   39篇
  2001年   5篇
  2000年   4篇
  1999年   4篇
  1998年   4篇
  1997年   6篇
  1996年   7篇
  1995年   3篇
  1993年   4篇
  1992年   5篇
  1990年   2篇
  1989年   2篇
  1988年   2篇
  1982年   1篇
  1978年   1篇
  1976年   1篇
  1975年   3篇
  1974年   5篇
  1973年   2篇
  1972年   4篇
  1971年   1篇
  1970年   1篇
  1969年   2篇
  1968年   1篇
排序方式: 共有1868条查询结果,搜索用时 250 毫秒
991.
Today, to increase effectiveness is a Strategy for success of organizations and their viability. In health care organization not only service cost- effectiveness is a major problem for productivity and organizational management but also customer-centred is in first priority. Because of these reasons, most of health organization trend to patient satisfaction for their viability. If complex process implemented for viability without attention to patient satisfaction, this is no success result. The FOCUS PDCA process is a new strategy for effectiveness of service quality. To this reason, the recent research done and its objective is to assess effect of FOCUS PDCA process strategy on patient satisfaction in surgery units of hospitals affiliated to Tehran Medical University. This research is a semi experimental with non- equivalent design. The sample was all of patients who hospitalized in two selected surgery units. Self-report was method of data gathering. Patient satisfaction assessed with questionnaire in pre and posttest. Then manipulation implemented as post-operation care process selected. Modelling and opportunity statement Diagrams prepared and improvement team organized. Flow process, convergences and cause- effect charts used to prepare list of items to be improved. Executive program was written. This include personnel training, standard implementation, election and training of quality control nurses (Q.C Ns), daily QC of caring and providing appropriate feed back to personnel, forming group session for determining corrective actions. Then after 1 month patient satisfaction was assessed. Statistical analysis shows this process increase patient satisfaction and it leads to care effectiveness. The findings of the pre-intervention phase indicated that the satisfaction level had been low in both groups and it is not significantly different in the two groups (P> 0.05). There was a significant difference before and after following intervention in the case study group (P>0.0001). FOCUS PDCA is effective method for access to various objectives especially patient satisfaction. it is suggested other researcher assess effects of this strategy for other indexes and total care process effectiveness.  相似文献   
992.
Sulfur mustard (SM) is a potent chemical warfare agent that was widely used during the First World War and the Iran-Iraq conflict. This vesicant agent causes several acute and chronic effects on the skin, eye, and respiratory system. We report the case of a 41-year-old man who was injured with SM in Iraq chemical attack in 1988. After exposure, he developed severe skin blisters on his upper trunk, dorsum of hands, and genitalia. Based on several clinical observations, such as atrophy, pigmentation, and vascular changes on genitalia with relevant findings in histopathological studies, persistent pigmentation, and damaged skin appendix in hand lesions, a diagnosis of "SM-induced poikiloderma" was postulated. The absence of any complication on the palmar aspect of hands is another remarkable finding in presented case, which suggests a plausible role of the palms as a vector for transporting SM to other sites of the skin.  相似文献   
993.
994.

Objective

To evaluate the use of diffusion tensor imaging (DTI) and fractional anisotropy (FA) as prognostic tools in anticipating the recovery of stroke patients.

Patients and methods

40 patients were included in our study after exclusion of 23 patients. All patients admitted in Neurology Department with stroke. The patients subjected to National Institute of Health Stroke Scale (NIHSS) followed by MRI with DTI and FA calculation. Follow up after three months was done based on the Modified Rankin Score (MRS). The results were compared and statistically analyzed.

Results

There was a statistical significant between the NIHSS and DTI pattern at the time of admission (p value?<?0.05) reflecting the severity of the stroke with 22 patients showed disrupted fibers (55%), of which 16 patients were categorized as moderate NIHSS and 19 patients showed poor outcome. Relative FA equal 0.8 was found to be the cut off value in predicting the poor or good prognosis using MRS as a reference with 94.4% sensitivity, 90.9% specificity and 0.833 area under curve.

Conclusion

DTI is a prognostic tool in anticipating the recovery of the stroke patients. Moreover, the relative FA score works as more additive value in evaluation of the patient improvement.  相似文献   
995.

Objective

To detect the effect of combined oral contraceptive pills (COC) on dynamic postural balance in healthy middle aged women.

Materials and methods

A prospective randomized controlled study included 200 patients classified into two groups. Group I received COC containing 30 μg of EE and 3 mg of drospirenone for 12 consecutive cycles and Group II received no treatment. Overall, medio-lateral and antero-posterior stability were measured using Biodex system after 12 months.

Results

There was a highly statistically significant difference between the 2 study groups regarding estradiol level (12.84 ± 1.96 vs. 38.86 ± 3.99, P value < 0.001) and progesterone level (0.52 ± 0.25 vs. 11.64 ± 4.53, P value < 0.001). There was a highly statistically significant difference between the 2 study groups regarding mediolateral stability (1.84 ± 0.23 vs. 2.40 ± 0.56, P value < 0.001), antereoposterior stability (1.91 ± 0.29 vs. 2.33 ± 0.61, P value < 0.001) or overall stability (2.42 ± 0.29 vs. 2.95 ± 0.53, P value < 0.001).

Conclusion

COC are effective method of contraception to improve postural balance and decrease risk of injury in normal and athletic women.NCT02855294.  相似文献   
996.
SYCP3 (Sinaptonemal complex protein 3) plays a critical role in pairing and recombination of homologous chromosomes in meiosis 1. It has been shown that lack of this gene leads to infertility in male and weakened fertility in female mice. In a case–control study, we investigated the SYCP3T657C polymorphism in the genome of 100 Iranian women with recurrent pregnancy losses of unknown causes as well as 100 control samples of normal fertile women having at least one healthy child. The general aim of our study was to determine whether there is a relationship between genetic changes in the SYCP3 gene and recurrent pregnancy loss in human or not. Frequency of the heterozygous genotype and mutated allele C were significantly higher in women with recurrent pregnancy losses (P-value < 0.005). Our findings suggest that the T657C polymorphism of the SYCP3 gene is possibly associated with recurrent pregnancy loss of unknown cause in human.  相似文献   
997.
998.
Background  The effect of esophageal distention (ED) on gastric motility has been well documented, but only a few investigations have been carried out about the effect of ED on gastric secretions. The aim of this study was to investigate the effect of ED on gastric acid and pepsin secretions and the mechanisms involved. Methods  Male adult Wistar rats (200–240 g) were anesthetized by urethane [1.2 g/kg, intraperitoneally (i.p.)] and underwent tracheostomy and laparotomy. A catheter was inserted in the stomach through the duodenum for gastric washout and distention followed by the esophageal distention by a balloon (0.3 ml, 10 min). Gastric acid secretion was stimulated by gastric distension (1.5 ml/100 g body weight), pentagastrin (20 μg/kg, i.p.), or insulin (0.6 IU/kg, i.p.). Pepsin secretion was stimulated by carbachol (20 μg/kg, i.p.). Effects of cervical vagotomy and reserpine (1 mg/kg, i.p.) were also investigated. Results  Gastric distention-, pentagastrin-, and insulin-stimulated gastric acid secretion was reduced by esophageal distention (P < 0.001, P < 0.05, and P < 0.05, respectively). Carbachol-induced pepsin secretion was also attenuated by esophageal distention (P < 0.05). Cervical vagotomy abolished the inhibitory effect of ED on pentagastrin-induced gastric acid secretion. In reserpinized rats, ED reduced the basal gastric acid secretion (P < 0.05). Conclusions  These results indicate that the vagus nerves are involved in the inhibitory effect of esophageal distension on gastric secretory function.  相似文献   
999.
1000.
Breast needle core biopsy (NCB) is now a standard diagnostic procedure in the triple assessment of screen detected breast lesions. However, unlike fine needle aspiration (FNA) cytology, information on the miss rate including false-negative diagnoses (FN) of malignancy (benign ‘B2’ or normal ‘B1’ NCB with a malignant outcome) is limited.MethodsA large series of NCBs (121, 742) performed over an 8-year period has been studied to assess the frequency and causes of missing a malignant diagnosis on NCB and to evaluate their impact on patients’ management in the screening service.ResultsDuring the period of this study, 50,691 were diagnosed as B2 and 9599 were diagnosed as B1. Of those, 779 B2 and 919 B1 were diagnosed as malignant on the subsequent surgical specimens, respectively, giving a FN rate of 3.0%. However when year of diagnosis was taken into consideration, we found that during the period 1999–2001, the FN rate for B2 was 2.7% while the miss rate for B1 was 4.0%. This showed marked improvement over time to reach a figure of 0.5% and 0.5% for B2 and B1, respectively, during the period 2005–2007. On detailed review of cases from a single screening region diagnosed during the last 3 years (2005–2008), 14 cases (0.17% of all NCBs) with malignant surgery were diagnosed as B2 (seven cases; FN rate 0.19%) and B1 (seven cases; B1 biopsy rate from cancer 0.19%). In these cases, NCB was unsatisfactory, there was a discrepancy between radiological abnormalities and histological findings with recommendation for excision or suspicious/malignant cytological diagnosis on concurrent FNA material. Therefore, our results indicate that the malignancy miss rate on NCB is rare and FN NCB diagnoses had no impact on patient management.  相似文献   
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号