全文获取类型
收费全文 | 1761篇 |
免费 | 97篇 |
国内免费 | 10篇 |
专业分类
耳鼻咽喉 | 44篇 |
儿科学 | 27篇 |
妇产科学 | 58篇 |
基础医学 | 195篇 |
口腔科学 | 87篇 |
临床医学 | 144篇 |
内科学 | 388篇 |
皮肤病学 | 22篇 |
神经病学 | 100篇 |
特种医学 | 59篇 |
外科学 | 323篇 |
综合类 | 32篇 |
一般理论 | 1篇 |
预防医学 | 103篇 |
眼科学 | 28篇 |
药学 | 103篇 |
中国医学 | 6篇 |
肿瘤学 | 148篇 |
出版年
2024年 | 3篇 |
2023年 | 26篇 |
2022年 | 58篇 |
2021年 | 108篇 |
2020年 | 59篇 |
2019年 | 83篇 |
2018年 | 114篇 |
2017年 | 60篇 |
2016年 | 68篇 |
2015年 | 65篇 |
2014年 | 87篇 |
2013年 | 110篇 |
2012年 | 163篇 |
2011年 | 169篇 |
2010年 | 95篇 |
2009年 | 76篇 |
2008年 | 90篇 |
2007年 | 81篇 |
2006年 | 85篇 |
2005年 | 72篇 |
2004年 | 46篇 |
2003年 | 41篇 |
2002年 | 39篇 |
2001年 | 5篇 |
2000年 | 4篇 |
1999年 | 4篇 |
1998年 | 4篇 |
1997年 | 6篇 |
1996年 | 7篇 |
1995年 | 3篇 |
1993年 | 4篇 |
1992年 | 5篇 |
1990年 | 2篇 |
1989年 | 2篇 |
1988年 | 2篇 |
1982年 | 1篇 |
1978年 | 1篇 |
1976年 | 1篇 |
1975年 | 3篇 |
1974年 | 5篇 |
1973年 | 2篇 |
1972年 | 4篇 |
1971年 | 1篇 |
1970年 | 1篇 |
1969年 | 2篇 |
1968年 | 1篇 |
排序方式: 共有1868条查询结果,搜索用时 250 毫秒
991.
Today, to increase effectiveness is a Strategy for success of organizations and their viability. In health care organization not only service cost- effectiveness is a major problem for productivity and organizational management but also customer-centred is in first priority. Because of these reasons, most of health organization trend to patient satisfaction for their viability. If complex process implemented for viability without attention to patient satisfaction, this is no success result. The FOCUS PDCA process is a new strategy for effectiveness of service quality. To this reason, the recent research done and its objective is to assess effect of FOCUS PDCA process strategy on patient satisfaction in surgery units of hospitals affiliated to Tehran Medical University. This research is a semi experimental with non- equivalent design. The sample was all of patients who hospitalized in two selected surgery units. Self-report was method of data gathering. Patient satisfaction assessed with questionnaire in pre and posttest. Then manipulation implemented as post-operation care process selected. Modelling and opportunity statement Diagrams prepared and improvement team organized. Flow process, convergences and cause- effect charts used to prepare list of items to be improved. Executive program was written. This include personnel training, standard implementation, election and training of quality control nurses (Q.C Ns), daily QC of caring and providing appropriate feed back to personnel, forming group session for determining corrective actions. Then after 1 month patient satisfaction was assessed. Statistical analysis shows this process increase patient satisfaction and it leads to care effectiveness. The findings of the pre-intervention phase indicated that the satisfaction level had been low in both groups and it is not significantly different in the two groups (P> 0.05). There was a significant difference before and after following intervention in the case study group (P>0.0001). FOCUS PDCA is effective method for access to various objectives especially patient satisfaction. it is suggested other researcher assess effects of this strategy for other indexes and total care process effectiveness. 相似文献
992.
Emadi SN Kaffashi M Poursaleh Z Akhavan-Moghaddam J Soroush MR Emadi SE Taghavi NO 《Cutaneous and ocular toxicology》2011,30(2):170-174
Sulfur mustard (SM) is a potent chemical warfare agent that was widely used during the First World War and the Iran-Iraq conflict. This vesicant agent causes several acute and chronic effects on the skin, eye, and respiratory system. We report the case of a 41-year-old man who was injured with SM in Iraq chemical attack in 1988. After exposure, he developed severe skin blisters on his upper trunk, dorsum of hands, and genitalia. Based on several clinical observations, such as atrophy, pigmentation, and vascular changes on genitalia with relevant findings in histopathological studies, persistent pigmentation, and damaged skin appendix in hand lesions, a diagnosis of "SM-induced poikiloderma" was postulated. The absence of any complication on the palmar aspect of hands is another remarkable finding in presented case, which suggests a plausible role of the palms as a vector for transporting SM to other sites of the skin. 相似文献
993.
994.
Emad H. Abdeldayem Ahmed M. Osman Tamer M. Roushdy 《The Egyptian Journal of Radiology and Nuclear Medicine》2017,48(4):1019-1025
Objective
To evaluate the use of diffusion tensor imaging (DTI) and fractional anisotropy (FA) as prognostic tools in anticipating the recovery of stroke patients.Patients and methods
40 patients were included in our study after exclusion of 23 patients. All patients admitted in Neurology Department with stroke. The patients subjected to National Institute of Health Stroke Scale (NIHSS) followed by MRI with DTI and FA calculation. Follow up after three months was done based on the Modified Rankin Score (MRS). The results were compared and statistically analyzed.Results
There was a statistical significant between the NIHSS and DTI pattern at the time of admission (p value?<?0.05) reflecting the severity of the stroke with 22 patients showed disrupted fibers (55%), of which 16 patients were categorized as moderate NIHSS and 19 patients showed poor outcome. Relative FA equal 0.8 was found to be the cut off value in predicting the poor or good prognosis using MRS as a reference with 94.4% sensitivity, 90.9% specificity and 0.833 area under curve.Conclusion
DTI is a prognostic tool in anticipating the recovery of the stroke patients. Moreover, the relative FA score works as more additive value in evaluation of the patient improvement. 相似文献995.
Ahmed M. Maged Emad Salah Ahmed M. Kamel Ahmed M. Hussein Hany Saad Hadeer Meshaal Wafaa M. Kamal 《Taiwanese journal of obstetrics & gynecology》2017,56(4):463-466
Objective
To detect the effect of combined oral contraceptive pills (COC) on dynamic postural balance in healthy middle aged women.Materials and methods
A prospective randomized controlled study included 200 patients classified into two groups. Group I received COC containing 30 μg of EE and 3 mg of drospirenone for 12 consecutive cycles and Group II received no treatment. Overall, medio-lateral and antero-posterior stability were measured using Biodex system after 12 months.Results
There was a highly statistically significant difference between the 2 study groups regarding estradiol level (12.84 ± 1.96 vs. 38.86 ± 3.99, P value < 0.001) and progesterone level (0.52 ± 0.25 vs. 11.64 ± 4.53, P value < 0.001). There was a highly statistically significant difference between the 2 study groups regarding mediolateral stability (1.84 ± 0.23 vs. 2.40 ± 0.56, P value < 0.001), antereoposterior stability (1.91 ± 0.29 vs. 2.33 ± 0.61, P value < 0.001) or overall stability (2.42 ± 0.29 vs. 2.95 ± 0.53, P value < 0.001).Conclusion
COC are effective method of contraception to improve postural balance and decrease risk of injury in normal and athletic women.NCT02855294. 相似文献996.
Ali Sazegari Seyyed Mehdi Kalantar Hossein Pashaiefar Shirin Mohtaram Negar Honarvar Zahra Feizollahi Nasrin Ghasemi 《Journal of assisted reproduction and genetics》2014,31(10):1377-1381
SYCP3 (Sinaptonemal complex protein 3) plays a critical role in pairing and recombination of homologous chromosomes in meiosis 1. It has been shown that lack of this gene leads to infertility in male and weakened fertility in female mice. In a case–control study, we investigated the SYCP3T657C polymorphism in the genome of 100 Iranian women with recurrent pregnancy losses of unknown causes as well as 100 control samples of normal fertile women having at least one healthy child. The general aim of our study was to determine whether there is a relationship between genetic changes in the SYCP3 gene and recurrent pregnancy loss in human or not. Frequency of the heterozygous genotype and mutated allele C were significantly higher in women with recurrent pregnancy losses (P-value < 0.005). Our findings suggest that the T657C polymorphism of the SYCP3 gene is possibly associated with recurrent pregnancy loss of unknown cause in human. 相似文献
997.
998.
Seyyed Ali Mard Mohammad Kazem Gharib Naseri Mohammad Badavi 《Journal of gastroenterology》2009,44(2):132-138
Background The effect of esophageal distention (ED) on gastric motility has been well documented, but only a few investigations have
been carried out about the effect of ED on gastric secretions. The aim of this study was to investigate the effect of ED on
gastric acid and pepsin secretions and the mechanisms involved.
Methods Male adult Wistar rats (200–240 g) were anesthetized by urethane [1.2 g/kg, intraperitoneally (i.p.)] and underwent tracheostomy
and laparotomy. A catheter was inserted in the stomach through the duodenum for gastric washout and distention followed by
the esophageal distention by a balloon (0.3 ml, 10 min). Gastric acid secretion was stimulated by gastric distension (1.5
ml/100 g body weight), pentagastrin (20 μg/kg, i.p.), or insulin (0.6 IU/kg, i.p.). Pepsin secretion was stimulated by carbachol
(20 μg/kg, i.p.). Effects of cervical vagotomy and reserpine (1 mg/kg, i.p.) were also investigated.
Results Gastric distention-, pentagastrin-, and insulin-stimulated gastric acid secretion was reduced by esophageal distention (P < 0.001, P < 0.05, and P < 0.05, respectively). Carbachol-induced pepsin secretion was also attenuated by esophageal distention (P < 0.05). Cervical vagotomy abolished the inhibitory effect of ED on pentagastrin-induced gastric acid secretion. In reserpinized
rats, ED reduced the basal gastric acid secretion (P < 0.05).
Conclusions These results indicate that the vagus nerves are involved in the inhibitory effect of esophageal distension on gastric secretory
function. 相似文献
999.
1000.
Emad A. Rakha Andrew H.S. Lee Jacquie Reed Alison Murphy Maysa El-Sayed Helen Burrell Andrew J. Evans Ian O. Ellis 《European journal of cancer (Oxford, England : 1990)》2010,46(10):1835-1840
Breast needle core biopsy (NCB) is now a standard diagnostic procedure in the triple assessment of screen detected breast lesions. However, unlike fine needle aspiration (FNA) cytology, information on the miss rate including false-negative diagnoses (FN) of malignancy (benign ‘B2’ or normal ‘B1’ NCB with a malignant outcome) is limited.MethodsA large series of NCBs (121, 742) performed over an 8-year period has been studied to assess the frequency and causes of missing a malignant diagnosis on NCB and to evaluate their impact on patients’ management in the screening service.ResultsDuring the period of this study, 50,691 were diagnosed as B2 and 9599 were diagnosed as B1. Of those, 779 B2 and 919 B1 were diagnosed as malignant on the subsequent surgical specimens, respectively, giving a FN rate of 3.0%. However when year of diagnosis was taken into consideration, we found that during the period 1999–2001, the FN rate for B2 was 2.7% while the miss rate for B1 was 4.0%. This showed marked improvement over time to reach a figure of 0.5% and 0.5% for B2 and B1, respectively, during the period 2005–2007. On detailed review of cases from a single screening region diagnosed during the last 3 years (2005–2008), 14 cases (0.17% of all NCBs) with malignant surgery were diagnosed as B2 (seven cases; FN rate 0.19%) and B1 (seven cases; B1 biopsy rate from cancer 0.19%). In these cases, NCB was unsatisfactory, there was a discrepancy between radiological abnormalities and histological findings with recommendation for excision or suspicious/malignant cytological diagnosis on concurrent FNA material. Therefore, our results indicate that the malignancy miss rate on NCB is rare and FN NCB diagnoses had no impact on patient management. 相似文献