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41.
This study investigates the potential application of an efficient, easily recoverable and reusable magnetically separable Fe3O4/KCC-1/APTPOSS nanoparticle-supported salen/Pd(ii) catalyst for C–C and C–H cross-couplings. The Fe3O4/KCC-1/APTPOSS/salen/Pd(ii) MNPs were thoroughly characterized by using TEM, FE-SEM, TGA, XRD, VSM, FT-IR, ICP-MS, and BET. This observation was exploited in the direct and selective chemical reaction of 2-acetyl-benzaldehyde with cyclopentadiene for the synthesis of pentafulvene. The recycled catalyst has been analyzed by ICP-MS showing only minor changes in the morphology after the reaction, thus confirming the robustness of the catalyst.This study investigates the potential application of an efficient, easily recoverable and reusable magnetically separable Fe3O4/KCC-1/APTPOSS nanoparticle-supported salen/Pd(ii) catalyst for C–C and C–H cross-couplings. 相似文献
42.
Seyed Fazel Nabavi Arianna Di Lorenzo Morteza Izadi Eduardo Sobarzo-Sánchez Maria Daglia Seyed Mohammad Nabavi 《Nutrients》2015,7(9):7729-7748
Herbs and spices have been used since ancient times, because of their antimicrobial properties increasing the safety and shelf life of food products by acting against foodborne pathogens and spoilage bacteria. Plants have historically been used in traditional medicine as sources of natural antimicrobial substances for the treatment of infectious disease. Therefore, much attention has been paid to medicinal plants as a source of alternative antimicrobial strategies. Moreover, due to the growing demand for preservative-free cosmetics, herbal extracts with antimicrobial activity have recently been used in the cosmetic industry to reduce the risk of allergies connected to the presence of methylparabens. Some species belonging to the genus Cinnamomum, commonly used as spices, contain many antibacterial compounds. This paper reviews the literature published over the last five years regarding the antibacterial effects of cinnamon. In addition, a brief summary of the history, traditional uses, phytochemical constituents, and clinical impact of cinnamon is provided. 相似文献
43.
Melika Ehtesham-Gharaee Ameneh Eshaghi Susan Shojaee Javad Asili Seyed Ahmad Emami Javad Behravan 《Drug and chemical toxicology》2015,38(3):293-299
Context: Scutellaria lindbergii Rech. f. (Lamiaceae) is an Iranian species of Scutellaria which has been shown to exert antimicrobial, antioxidant and cytotoxic effects. Objective: The protective properties of total methanol extract (TME) of S. lindbergii and its fractions (defatted and CH2Cl2) were investigated against cytotoxic and genotoxic effects of H2O2 in NIH 3T3 cell line as non-malignant cells. Materials and methods: The cells were incubated with different concentrations of S. lindbergii root extracts [TME (15–250?μg ml?1), defatted fraction (15–500?μg ml?1) and CH2Cl2 fraction (5–40?μg ml?1)] and toxic concentration of H2O2 (200?µM) at 37?°C for 2?h concurrently and Cell viability was quantitated by MTT assay. The antigenotoxic effect of extracts was investigated using comet assay. The cells were incubated with extracts [TME (25–250?μg ml?1), defatted fraction (25–500?μg ml?1) and CH2Cl2 fraction (5–40?μg ml?1)] and H2O2 (25?µM) at 4?°C for 20?min, then the comet assay was performed. DNA damage was expressed as percentage tail DNA. Results: Total methanol extract of S. lindbergii and its fractions had a significant inhibitory effect on DNA damage. The IC50 values of TME, defatted fraction and CH2Cl2 fraction against DNA damage were determined as 48, 138 and 8?μg ml?1, respectively. Conclusion: S. lindbergii extracts can prevent oxidative DNA damage, which is likely due to its flavonoids and phenolic compounds as antioxidant constituents. 相似文献
44.
Esalatmanesh Kamal Loghman Amirhossein Esalatmanesh Roozbeh Soleimani Zahra Khabbazi Alireza Mahdavi Aida Malek Mousavi Seyed Gholam Abbas 《Clinical rheumatology》2021,40(9):3591-3597
Clinical Rheumatology - Considering the pathologic significance of inflammation and oxidative stress in rheumatoid arthritis (RA) as well as the antioxidant, anti-inflammatory and hypolipidemic... 相似文献
45.
Seyed Ahmad Samsamshariat Mehrnoosh Hashemzadeh Zahra Samsamshariat Mohammad-Reza Movahed 《Cardiovascular Revascularization Medicine》2005,6(2):70-72
BACKGROUND: Polyethylene Glycol (PEG) is a solvent and used in a wide range of biomedical applications. Many fatty-acid-based molecules cannot be administered without a solvent in vivo. PEG can be used to dissolve compounds to make them water soluble. However, the effect of PEG on the cardiovascular system has not been studied. In this study, we evaluated the effect of PEG on the cardiovascular system in rat models. METHODS: Twenty male Sprague-Dawley rats weighing 250-300 g were used in this study. The control group (10 rats) were injected intraperitoneally with 0.5 ml of 5% D/W in normal saline and the second group (10 rats) with PEG 400, 2 ml/kg ip, twice a day for 1 week. After 4 weeks, the rats underwent general anesthesia and a 1.4 French ultra miniature pressure volume catheter (Millar catheter) was placed in the left ventricle via the right carotid artery to measure comprehensive hemodynamic data. The data were analyzed with PVAN pressure-volume analysis software. RESULTS: All the systolic and diastolic parameters were similar in both groups except for the effective arterial elastance (Ea), which was decreased in the PEG group. There were no significant differences in maximum (dp/dt(max)) and minimum (dp/dt(min)) development of pressure stroke work, cardiac output, ejection fraction, end systolic volume (Ves), and end diastolic volume. CONCLUSIONS: We have demonstrated that PEG, as a solvent, decreases Ea in rats in comparison to a placebo. Therefore, PEG as a solvent should be used cautiously in the cardiovascular research. 相似文献
46.
Seyed Morteza Shamshirgaran Louisa Jorm Sanja Lujic Hilary Bambrick 《Primary Care Diabetes》2019,13(1):71-81
Background
Ethnic variation in the occurrence of type 2 diabetes, complications, mortality, and health behaviours has been reported. The current research examined patterns of health-related outcomes by country of birth in people with diabetes aged 45 years and over in New South Wales, Australia.Methods
This study was based on the baseline data of 266,848 participants aged 45 years and over from “The Sax Institute’s 45 and Up Study” (2006–2009), NSW; Australia’s most populous state. Health-related factors including self-rated overall health, Quality of Life (QoL), eyesight, subjective memory complaint, hearing loss, psychological distress and functional limitation were examined according to country of birth among 23,112 people with type 2 diabetes. Logistic regression modelling was used to compare the odds of poor outcomes between Australian-born and overseas-born participants, adjusting for potential confounding and mediating variables. Both age-sex and fully adjusted odds ratios (aORs) are reported.Results
Nearly half of the people with diabetes in the sample reported hearing loss and high levels of functional limitations, a third reported poor overall health. Compared to people with diabetes born in Australia, people born in South East Europe, North Africa, the Middle East had significantly greater odds of poor outcomes across the majority of examined health-related factors, with the largest odds observed in the elevated level of psychological distress outcome (aOR = 3.4 in North African and the Middle East group). Higher aORs of poor overall health, QoL, memory problems and poor eyesight, and lower aORs for hearing loss, were also found among those born in the Asian countries.Conclusions
The results demonstrated significant ethnic disparity in the prevalence of health-related outcomes. These findings provide important context for the formulation of culturally sensitive secondary prevention strategies. 相似文献47.
Arezou Masteri Farahani Fariba Maleki Nourollah Sadeghzadeh Saeid Abediankenari Seyed Mohammad Abedi Mostafa Erfani 《Chemical biology & drug design》2020,96(2):850-860
Prostate cancer is a serious threat to men's health, so it is necessary to develop the techniques for early detection of this malignancy. Radiolabeled peptides are the useful tools for diagnosis of prostate cancer. In this research, we designed a new HYNIC‐conjugated GnRH analogue and labeled it by 99mTc with tricine/EDDA as coligands. We used aminohexanoic acid (Ahx) as a hydrocarbon linker to generate 99mTc‐(tricine/EDDA)‐HYNIC‐Ahx‐[DLys6]GnRH. The radiopeptide exhibited high radiochemical purity and stability in solution and serum. Two human prostate cancer cell lines LN‐CaP and DU‐145 were used for cellular experiments. The binding specificity and affinity of radiopeptide for LN‐CaP were superior to DU‐145 cells. The Kd values for LN‐CaP and DU‐145 cells were 41.91 ± 7.03 nM and 55.96 ± 10.56 nM, respectively. High kidney uptake proved that the main excretion route of radiopeptide was through the urinary system. The tumor/muscle ratio of 99mTc‐HYNIC‐Ahx‐[DLys6]GnRH was 4.14 at 1 hr p.i. that decreased to 2.41 at 4 hr p.i. in LN‐CaP tumor‐xenografted nude mice. The blocking experiment revealed that the tumor uptake was receptor‐mediated. The lesion was visualized clearly using 99mTc‐[DLys6]GnRH at 1 hr p.i. Accordingly, this research highlights the capability of 99mTc‐(tricine/EDDA)‐HYNIC‐Ahx‐[DLys6]GnRH peptide as a promising agent for GnRHR‐expressing tumor imaging. 相似文献
48.
Isabel Siow Keng Siang Lee John J.Y. Zhang Seyed Ehsan Saffari Adeline Ng Barnaby Young 《Journal of stroke and cerebrovascular diseases》2021,30(3):105549
IntroductionCOVID-19 is a multi-system infection which predominantly affects the respiratory system, but also causes systemic inflammation, endothelialitis and thrombosis. The consequences of this include renal dysfunction, hepatitis and stroke. In this systematic review, we aimed to evaluate the epidemiology, clinical course, and outcomes of patients who suffer from stroke as a complication of COVID-19.MethodsWe conducted a systematic review of all studies published between November 1, 2019 and July 8, 2020 which reported on patients who suffered from stroke as a complication of COVID-19.Results326 studies were screened, and 30 studies reporting findings from 55,176 patients including 899 with stroke were included. The average age of patients who suffered from stroke as a complication of COVID-19 was 65.5 (Range: 40.4–76.4 years). The average incidence of stroke as a complication of COVID-19 was 1.74% (95% CI: 1.09% to 2.51%). The average mortality of stroke in COVID-19 patients was 31.76% (95% CI: 17.77% to 47.31%). These patients also had deranged clinical parameters including deranged coagulation profiles, liver function tests, and full blood counts.ConclusionAlthough stroke is an uncommon complication of COVID-19, when present, it often results in significant morbidity and mortality. In COVID-19 patients, stroke was associated with older age, comorbidities, and severe illness. 相似文献
49.
Xu Zheyu Anderson Kirstie N. Saffari Seyed Ehsan Lawson Rachael A. Chaudhuri K. Ray Brooks David Pavese Nicola 《Journal of neurology》2021,268(1):312-320
Journal of Neurology - Sleep disorders can occur in early Parkinson’s disease (PD). However, the relationship between different sleep disturbances and their longitudinal evolution has not... 相似文献
50.
Alexey A. Shadrin PhD Sören Mucha PhD David Ellinghaus PhD Mary B. Makarious BSc Cornelis Blauwendraat PhD Ashwin A.K. Sreelatha MSc Antonio Heras-Garvin PhD Jinhui Ding PhD Monia Hammer PhD Alexandra Foubert-Samier MD Wassilios G. Meissner MD Olivier Rascol PhD Anne Pavy-Le Traon MD Oleksandr Frei PhD Kevin S. O'Connell PhD Shahram Bahrami PhD Stefan Schreiber MD Wolfgang Lieb MD Martina Müller-Nurasyid PhD Ulf Schminke MD Georg Homuth PhD Carsten O. Schmidt PhD Markus M. Nöthen MD Per Hoffmann PhD Christian Gieger PhD Gregor Wenning MD for the European Multiple System Atrophy Study Group J. Raphael Gibbs PhD Andre Franke PhD John Hardy PhD Nadia Stefanova PhD Thomas Gasser MD Andrew Singleton PhD Henry Houlden MD Sonja W. Scholz MD Ole A. Andreassen PhD Manu Sharma PhD 《Movement disorders》2021,36(2):449-459