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排序方式: 共有383条查询结果,搜索用时 15 毫秒
31.
Firtina Sinem Ng Yuk Yin Ng Ozden H. Kiykim Ayca Ozek Esra Yucel Kara Manolya Aydiner Elif Nepesov Serdar Camcioglu Yildiz Sayar Esra H. Gungoren Ezgi Yalcin Reisli Ismail Torun Selda H. Haskologlu Sule Cogurlu Tuba Kaya Aysenur Cekic Sukru Baris Safa Ozbek Ugur Ozen Ahmet Sayitoglu Muge 《Immunologic research》2022,70(1):134-134
Immunologic Research - 相似文献
32.
Oruç MT Ozmen MM Kazan O Düzgün AP Ozkara HA Arik D Seçkin S Coşkun F 《Digestive diseases and sciences》2004,49(10):1681-1686
Strangulation is associated with an increased risk of mortality and morbidity in patients with mechanical bowel obstruction. The accurate and early recognition of the presence of strangulation is important to allow safe nonoperative treatment. A number of studies have shown that there was no single and reliable test to detect or exclude the presence of strangulation. The aim of this study was to evaluate the role of serum hexosaminidase (Hex) levels in recognition of strangulation in an experimental model of closed loop small bowel obstruction. Forty-two Wistar albino rats were divided into four groups: I, control (n = 5); II, sham laparotomy (n = 5); III, simple obstruction (n = 16); and IV, strangulation groups (n = 16). Activity levels of total Hex and its fractions (Hex A and B) were assayed in serum samples obtained from rats after 3 and 8 hr. Samples of small bowel were also evaluated histologically. Histological evaluation of bowel sections obtained from the strangulation group after 8 hr, revealed transmural hemorrhagic infarction in all animals with a mean +/- SD total Hex activity of 978.25 +/- 150 nmol/hr/ml, which was significantly higher than that in the other groups (P < 0.001). Although sections of bowel from the strangulation group after 3 hr showed severe ischemic injury, the activities of total Hex, Hex A, and Hex B were not different from those of the control, sham, and simple obstruction groups. Histological examination of these groups did not show any sign of ischemia. Total Hex, Hex A, and Hex B activities in the strangulation group were all significantly greater than the activities seen in the simple obstruction group (P < 0.001, for all). In conclusion, increased serum hex levels indicate irreversible transmural infarction only in the late period of strangulation in the closed loop small bowel obstruction model. It seems unuseful for detecting reversible and/or irreversible ischemia in the early period of strangulation. 相似文献
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34.
Leblebici B Pektaş ZO Ortancil O Hürcan EC Bagis S Akman MN 《Rheumatology international》2007,27(6):541-544
The purpose of this study was to determine the association of fibromyalgia (FM) with temporomandibular disorder (TMD) and
masticatory myofascial pain (MMP). Thirty-one consecutive women diagnosed as having FM according to American College of Rheumatology
criteria and 21 consecutive women diagnosed as having TMD were included in this prospective study. All patients were examined
by a dentist and a physiatrist to identify the coexistence of FM and TMD. In the FM group, TMD was found in 25 (80%) patients,
and only 6 (19%) patients had arthrogenous origin with MMP, whereas 19 (81%) patients had only MMP without arthrogeonous orgin
of those 25 women exhibited TMD. In the TMD group, the prevalence of FM was 52%, which was significantly higher in those with
TMD of arthrogenous origin with MMP. Our results indicate that coexistence of FM and TMD with MMP is high. Pain and tenderness
in the masticatory muscles appear to be an important element in FM, so in some patients it may be the leading complaint.
This study was supported financially by Baskent University Research Fund. 相似文献
35.
Comelekoglu U Bagis S Yalin S Ogenler O Yildiz A Sahin NO Oguz I Hatungil R 《Clinical rheumatology》2007,26(3):380-384
The aim of our study was to investigate the effects of ovariectomy on rat femur biomechanical parameters. Bone mineral density
(BMD) and histological investigation were also evaluated. Fourteen female Sprague–Dawley rats (seven ovariectomized, seven
control) were used. BMD was measured by dual-energy X-ray absorbsiometry. Bone biomechanical parameters were measured in femoral
midshaft with tensile test using a biomaterial testing machine and maximum load, stiffness, energy absorption capacity (structural
properties), ultimate stress, ultimate strain, and elastic modulus (material properties) were calculated. Diaphyseal cortical
bone thickness was measured by using histological method. The ovariectomized (OVX) rat femur’s BMD was 14% lower than control
rats (p=0.006). Mean maximum load was 55% less than the control group’s (p=0.0001). Stiffness was 72% less in OVX rats (p=0.05). Femurs of rats with OVX had 32% less absorbed energy than controls (p=0.09). From the stress–strain curve ultimate stress, ultimate strain and elastic modulus was calculated. Elastic modulus
was 53% less than controls (p=0.05). Ultimate stress decreased 21% in OVX rats (p=0.097). Ultimate strain was 25% less than controls in OVX rats. Cortical thickness was significantly decreased in OVX rats
than in controls (p<0.05). In conclusion, femur biomechanical parameters are decreased in osteoporosis. 相似文献
36.
Inga J Duignan Erik Corcoran Anthony Pennello Mary Jane Plym Michael Amatulli Nidia Claros Michelle Iacolina Hagop Youssoufian Larry Witte Selda Samakoglu Jonathan Schwartz David Surguladze James R Tonra 《Neoplasia (New York, N.Y.)》2011,13(1):49-59
The benefits of inhibiting vascular endothelial growth factor (VEGF) signaling in cancer patients are predominantly attributed to effects on tumor endothelial cells. Targeting non-endothelial stromal cells to further impact tumor cell growth and survival is being pursued through the inhibition of additional growth factor pathways important for the survival and/or proliferation of these cells. However, recent data suggest that VEGF receptor (VEGFR)-specific inhibitors may target lymphatic vessels and pericytes in addition to blood vessels. Here, in fact, we demonstrate that DC101 (40 mg/kg, thrice a week), an antibody specific to murine VEGFR2, significantly reduces all three of these stromal components in subcutaneous (SKRC-29) and orthotopic (786-O-LP) models of renal cell carcinoma (RCC) established in nu/nu athymic mice. Sunitinib (40 mg/kg, once daily), a receptor tyrosine kinase inhibitor of VEGFR2 and other growth factor receptors, also caused significant loss of tumor blood vessels in RCC models but had weaker effects than DC101 on pericytes and lymphatic vessels. In combination, sunitinib did not significantly add to the effects of DC101 on tumor blood vessels, lymphatic vessels, or pericytes. Nevertheless, sunitinib increased the effect of DC101 on tumor burden in the SKRC-29 model, perhaps related to its broader specificity. Our data have important implications for combination therapy design, supporting the conclusion that targeting VEGFR2 alone in RCC has the potential to have pleiotropic effects on tumor stroma. 相似文献
37.
Saygi S Alehan F Baskin E Bayrakci US Ulu EM Ozbek N 《Journal of child neurology》2008,23(11):1353-1356
Generalized edema can occur during the course of juvenile dermatomyositis. In this article, a 4-year-old boy with generalized nonpitting edema and proximal weakness is reported. Characteristic cutaneous lesions, laboratory tests, results of electromyography, and magnetic resonance imaging findings resulted in a diagnosis of juvenile dermatomyositis. He was treated with corticosteroids and methotrexate. It is concluded that the generalized edema may appear as the presenting cutaneous manifestation of juvenile dermatomyositis. 相似文献
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39.
Phlebectasia is a dilation of a vein. Jugular vein phlebectasia can occur in any part of the jugular venous system. It is an uncommon cause of cervical swelling in children. We report a rare case of bilateral internal jugular vein phlebectasia presenting as bilateral neck swelling in a child. We also review the literature on the clinical features of this entity and the differential diagnosis, methods of imaging, and treatment. 相似文献
40.