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91.
92.
Oxyphilic granular cell adenoma (oncocytoma) is extremely rare usually benign neoplasm. Specimens from four oncocytomas of the parotid gland were studied by light microscopy using different histochemical stains, and by electron microscopy. The haematoxylin and eosin stained sections revealed large cells with eosinophilic granular cytoplasm. These granules appear blue with phosphotungstic acid haematoxylin stain, purplish blue with mallory aniline blue stain and are moderately reactive to alcian blue and PAS. No elastic fibers could be seen in the intercellular substance using Verhoeff's stain. At the ultrastructural level, the tumour cells were characterized by great numbers of mitochondria. Many of the mitochondria contained glycogen granules. Dividing mitochondria were also observed.  相似文献   
93.
In acknowledging that ‘counselling is generally recognizedas beneficial’, the Human Fertilization and EmbryologyAuthority (HFEA) Code of Practice requires that all infertilityunits provide counselling facilities to be available for patients.In this study, we intended to evaluate the support and counsellingservices made available by the licensed units in the UK. A questionnaireconsisting of 30 questions was designed and sent to every licensedtreatment unit in the UK. The data were coded on a nominal scaleand, using a data entry program, loaded onto a computer. Usingthe Statistical Package for the Social Sciences program, a non-parametricfrequency analysis was performed. Associations were examinedwith cross-tabulations and x2 analysis. A total of 62 units(61.4%) responded to the questionnaire, from both the privateand National Health Service sectors. Of these, 95% have theirown counsellor, most of whom (84%) practised on the premises.One-third of these counsellors had a dual role, mainly as nurses,social workers or in administration; 98.6% were trained in counselling,with only 28% having either the Certificate or Diploma in Counselling.One-third (32.2%) of centres charged for counselling, with only13 units indicating their charges. The majority of centres (78.8%)do not actively follow-up patients after counselling and one-quarter(25.5%) did not have a specific counselling room. Over two-thirds(68.4%) of centres described their support network as adequate.The results of this survey suggest that, although the requirementsof the HFEA Code of Practice are being adhered to reasonablywell, overall patient uptake of counselling is low. The potentialbenefits of counselling are well documented, and therefore workersin this field need to place additional emphasis on the possibleadvantages of counselling in an effort to improve uptake.  相似文献   
94.
95.
Secretory differentiation of endometrium after multiple follicular stimulation using gonadotrophin releasing hormone and human menopausal gonadotrophin has been studied both histologically and immunohistochemically in 30 women undergoing in-vitro fertilization treatment. None had embryo transfer. Patients were randomly allocated to receive luteal phase support with a single dose of human chorionic gonadotrophin. The latter failed to produce any significant enhancement of endometrial structure or secretions. Appropriate glandular morphology was present in a greater proportion of those who were successfully stimulated than those who responded poorly. However, defective secretion of the cycle-dependent component studied, using monoclonal antibody D9B1, was demonstrated in two-thirds of cases regardless of the ovarian response. Early vascular maturation in the stroma was a common finding, and was thus considered as a feature of structural modulation of these endometria.  相似文献   
96.
Background: Cancer is a significant problem in modern medicine, also is the most common cause of death aftercardiovascular diseases, and in need of targeted drug release. Although, chemotherapy is an important candidate incancer treatment, but it has many side effects on healthy tissues of the body. Therefore, Nano technology is usedfor specific function, by the least side effects and damage to normal cells. Materials and method: In this study, thepharmacological properties of PEGylated Nano-niosomal Gingerol was examined. Noisome were prepared using reversephase evaporation method, which contains specific proportion of cholesterol, span60 and polyethylene glycol. Then,PEGylated the prepared formulation by PEG6600. The amount of release and encapsulation of the drug was investigated.The percentage of remains of cancer cell line T47D treated with PEGylated niosomal Gingerol. Results: The averagediameter of the nanoparticles, size distribution and zeta potential were reported for PEGylated niosomal sample 35.65nm, 0.17 and 21 mv, and for PEGylated niosomal drug sample 256.9 nm, 0.23 and 28 mv, respectively. The amountof OD for encapsulated drug was 0.198, also the amount of concentration of the drug which is not encapsulated, was0.77947 μl of the drug per ml. This value of encapsulated drug was 76.38 percent. Conclusion: The results showed thatIC50 of the formulation of PEGylated nanoniosomal Gingerol is less than the standard drug. It seems, the cause of thisphenomenon is due to the effect of Polyethylene glycol, in more stability and slower drug release, in the formulationof PEGylated niosome. Also, Polyethylene glycol makes increase in the drug dealing and its greater influence with thetarget cell. In this study, more than 76% of the Gingerol drug in PEGylated nanoniosomal formulation were enclose.Also, we could reduce the amount of drug release, as much as possible.  相似文献   
97.
98.
Premature ovarian failure   总被引:1,自引:0,他引:1  
PURPOSE OF REVIEW: To summarize current knowledge about premature ovarian failure (POF) with an emphasis on recent developments regarding its management. RECENT FINDINGS: The incidence of POF is increasing largely due to improved survival rates of cancer patients treated with radiation and chemotherapy. Delayed diagnosis and management of POF leads to suboptimal outcomes. Anticipation and early detection of this condition in high-risk women by means of ovarian function testing, followed by early institution of appropriate management could improve outcomes. Choice of strategies should vary depending on the age of onset, associated symptoms and fertility aspirations of the individual, and should change with the patient's advancing age. SUMMARY: Early assessment of the individual's risk of developing POF, development of a strategic management plan, and timely commencement of infertility and hormone deficiency treatment, together with counselling in an integrated management plan should improve both the short and long-term health of those with POF.  相似文献   
99.
A monoclonal antibody (CC25) was obtained after immunization of mice with intact glandular epithelial cells from secretory phase endometrium. Here we report a preliminary immunohistologic study in the endometrium of 29 patients in different phases of the menstrual cycle and early pregnancy. In immunofluorescence, CC25 binds to a basolaterally oriented epithelial cell surface antigen that is absent during the proliferative phase and appears suddenly in both glandular and uterine surface locations soon after ovulation. In mid and late secretory phase, the level of expression diminishes slowly. The epitope is absent from glandular epithelial cells in first-trimester decidua. However, it is associated with vascular smooth muscle cells in endometrium and decidua. CC25 promises to be a useful reagent for the analysis of endometrial function during the menstrual cycle.  相似文献   
100.
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