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排序方式: 共有465条查询结果,搜索用时 15 毫秒
101.
Barak Cohen Logan Glosser Remie Saab Michael Walters Ahmed Salih Mohammad Zafeer‐Khan Eva Rivas Kan Zhang Nadav Y. Schacham Praneeta Chodavarapu Hani Essber David Chelnick Syed Raza CeCelia Hanline Dilara Khoshknabi Dongsheng Yang John Seif Surendrasingh Chhabada Alparslan Turan 《Paediatric anaesthesia》2019,29(2):169-174
102.
Soheil Hassanipour Haleh Ghaem Morteza Arab-Zozani Mozhgan Seif Mohammad Fararouei Elham Abdzadeh Golnar Sabetian Shahram Paydar 《Injury》2019,50(2):244-250
Background
Currently, two models of artificial neural network (ANN) and logistic regression (LR) are known as models that extensively used in medical sciences. The aim of this study was to compare the ANN and LR models in prediction of Health-related outcomes in traumatic patients using a systematic review.Methods
The study was planned and conducted based on the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) checklist. A literature search of published studies was conducted using PubMed, Embase, Web of knowledge, Scopus, and Google Scholar in May 2018. Joanna Briggs Institute (JBI) checklists was used for assessing the quality of the included articles.Results
The literature searches yielded 326 potentially relevant studies from the primary searches. Overall, the review included 10 unique studies. The results of this study showed that the area under curve (AUC) for the ANN was 0.91, (95% CI 0.89–0.83) and 0.89, (95% CI 0.87–90) for the LR in random effect model. The accuracy rate for ANN and LR in random effect models were 90.5, (95% CI, 87.6–94.2) and 83.2, (95% CI 75.1–91.2), respectively.Conclusion
The results of our study showed that ANN has better performance than LR in predicting the terminal outcomes of traumatic patients in both the AUC and accuracy rate. Using an ANN to predict the final implications of trauma patients can provide more accurate clinical decisions. 相似文献103.
Leah A. Commander Alix E. Seif Iris G. Insogna Susan R. Rheingold 《British journal of haematology》2010,150(3):345-351
A combination of 5 d of nelarabine (AraG) with 5 d of etoposide (VP) and cyclophosphamide (CPM) and prophylactic intrathecal chemotherapy was used as salvage therapy in seven children with refractory or relapsed T‐cell leukaemia or lymphoma. The most common side effects attributable to the AraG included Grade 2 and 3 sensory and motor neuropathy and musculoskeletal pain. Haematological toxicity was greater for the combination than AraG alone, although median time to neutrophil and platelet recovery was consistent with other salvage therapies. All patients had some response to the combined therapy and five of the seven went into complete remission after one or two courses of AraG/VP/CPM. Our experience supports the safety of giving AraG as salvage therapy in synchrony with etoposide and cyclophosphamide, although neurological toxicity must be closely monitored. 相似文献
104.
H. Seif El Nasr O.G. Shaker M.M.T. Fawzi G. El‐Hanafi 《Journal of the European Academy of Dermatology and Venereology》2013,27(1):103-108
Background In healthy skin, there is a molecular microenvironment that favours the survival of melanocytes and regulates their function. Keratinocytes synthesize and secrete several cytokines that have stimulatory and inhibitory effects on melanocytes. Aim of the work This work was conducted to evaluate the expression of basic fibroblast growth factor (bFGF) and tumour necrosis factor alpha (TNF‐α) mRNA levels in lesional skin of vitiligo, hypopigmented mycosis fungoides and hypopigmented tinea versicolor. Patients and Methods Forty eight patients (25 vitiligo, 14 hypopigmented mycosis fungoides, 9 hypopigmented tinea versicolor) and 10 healthy controls were included. A 4 mm punch skin biopsy was taken from lesional skin of patients, and the normal skin of controls for quantitative PCR examination of TNF‐α and bFGF mRNA. Results The level of TNF‐α mRNA in lesional skin of the three studied disorders was significantly higher than in the control group, while the level of bFGF mRNA was significantly lower in lesional skin of the three diseases than the control skin. A significant inverse correlation was demonstrated between the mRNA levels of the two studied cytokines in vitiligo and hypopigmented MF lesions. Conclusion The study’s findings demonstrate that the studied hypopigmented (vitiligo, hypopigmented MF, hypopigmented TV) disorders show similar changes in their cutaneous microenvironment with increased TNF‐α and decreased bFGF mRNA expression. This cytokine microenvironment change may be implicated in the pigment loss and hence these cytokines may have future therapeutic implications. 相似文献
105.
Cost‐effectiveness of caries‐preventive fluoride varnish applications in clinic settings among patients of low,moderate and high risk 下载免费PDF全文
106.
107.
Tekaya Aicha Ben Mehmli Takwa Mrad Imtinene Ben Fendri Ahmed Boukriba Seif Bouden Selma Rouached Leila Tekaya Rawdha Saidane Olfa Mahmoud Ines Abdelmoula Leila 《Clinical rheumatology》2022,41(10):3017-3025
Clinical Rheumatology - We aimed to investigate the relationship between epicardial adipose tissue (EAT) thickness, flow-mediated dilation (FMD), and carotid intima-media thickness (cIMT) in... 相似文献
108.
Gina S. El-Feky Wael S. Mohamed Hanaa E. Nasr Naglaa M. El-Lakkany Sayed H. Seif el-Din Sanaa S. Botros 《Antimicrobial agents and chemotherapy》2015,59(6):3501-3508
Consideration of existing compounds always simplifies and shortens the long and difficult process of discovering new drugs specifically for diseases of developing countries, an approach that may add to the significant potential cost savings. This study focused on improving the biological characteristics of the already-existing antischistosomal praziquantel (PZQ) by incorporating it into montmorillonite (MMT) clay as a delivery carrier to overcome its known bioavailability drawbacks. The oral bioavailability of a PZQ-MMT clay nanoformulation and its in vivo efficacy against Schistosoma mansoni were investigated. The PZQ-MMT clay nanoformulation provided a preparation with a controlled release rate, a decrease in crystallinity, and an appreciable reduction in particle size. Uninfected and infected mice treated with PZQ-MMT clay showed 3.61- and 1.96-fold and 2.16- and 1.94-fold increases, respectively, in area under the concentration-time curve from 0 to 8 h (AUC0–8) and maximum concentration of drug in serum (Cmax), with a decrease in elimination rate constant (kel) by 2.84- and 1.35-fold and increases in the absorption rate constant (ka) and half-life (t1/2e) by 2.11- and 1.51-fold and 2.86- and 1.34-fold, respectively, versus the corresponding conventional PZQ-treated groups. This improved bioavailability has been expressed in higher efficacy of the drug, where the dose necessary to kill 50% of the worms was reduced by >3-fold (PZQ 50% effective dose [ED50] was 20.25 mg/kg of body weight for PZQ-MMT clay compared to 74.07 mg/kg for conventional PZQ), with significant reduction in total tissue egg load and increase in total immature, mature, and dead eggs in most of the drug-treated groups. This formulation showed better bioavailability, enhanced antischistosomal efficacy, and a safer profile despite the longer period of residence in the systemic circulation. Although the conventional drug''s toxicity was not examined, animal mortality rates were not different between groups receiving the test PZQ-clay nanoformulation and conventional PZQ. 相似文献
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