先天性无肛直肠舟状窝瘘手术186例

1临床资料1988-06/2003-12我院共186例,均为女性,无肛门,其中0～6月龄21例,0.5～1岁96例,1～3岁53例,3～8岁15例,13岁1例.以大便从会阴部舟状窝瘘口处排出而就诊,患儿有不同程度的排便困难,严重时伴腹胀呕吐,多数患儿有营养不良性贫血.瘘口直径0.3～0.6 cm,直肠盲端到肛穴皮肤之间的距离1.0～2.5 cm,属于中、低位肛门直肠畸形.本组有3例合并先天性心脏病-室间隔缺损,2例合并骶前囊肿,1例合并脐疝.     

抗痫灵在大鼠肝脏中代谢的研究

用离体大鼠肝脏灌流法,研究了抗痫灵在肝脏灌流过程中的代谢规律。用高效液相色谱法由灌流液中分离、制备得到了两种代谢物,经紫外吸收光谱与质谱鉴定,确定代谢物的结构为3,4-次甲基二氧桂皮酰羟基哌啶及阿魏酰哌啶,后者经化学合成得到了进一步的确证。本文还研究了肝循环过程中抗痫灵的代谢动力学,揭示了大部份抗痫灵以原形结合贮存于肝脏中。     

辅料对X线造影剂碘海醇注射液稳定性的影响

目的：考察不同辅料的国产碘海醇（Ｉｏｈｅｘｏｌ）注射液稳定性的影响。方法：测定高温灭菌前后６组不同辅料的碘海醇注射液ＰＨ、碘离子浓度、含量变化。结果与结论：同时含三羟甲基氨基甲烷（Ｔｒｉｓ,１．２ｍｇ／ｍｌ）、乙二胺四乙酸二钠钙（ＥＤＴＡ－Ｎａ２Ｃａ,０．１ｍｇ／ｍｌ）２种辅料时,碘海醇注射液最稳定。     

川芎嗪在兔体内代谢产物的研究

应用高效液相色谱法将川芎嗪在家兔血液中的代谢产物进行分离,对原药及两种代谢产物进行了紫外、红外、质谱、核磁共振等光谱分析,推断出川芎嗪代谢产物的结构,并用化学方法合成了代谢物对照品,对其结构进一步得到验证。     

Anatomical variations of the internal jugular veins and their relationship to the carotid arteries: A CT evaluation

The right internal jugular vein (IJV) is a common vessel to obtain venous access. It is important to have a clear understanding of the anatomy of the IJV and its relationship to the common carotid arteries (CCA) to avoid inadvertent arterial puncture. This study aims to objectively evaluate the variations in the anatomy of IJV and its relation to the CCA. A total of 176 right and left IJV were retrospectively evaluated using CT imaging with the CentraRad Diagnostic Viewer Version 4.09.0190 (CDN Telemedicine Solutions, Wollongong, Australia). The data were recorded and analysed. The right IJV (80.5%) was more often larger than the left IJV. With reference to the CCA, 85.2% of the IJV were found in the lateral position, 12.5% anteriorly, 1.1% medially and 1.1% posteriorly. Seven IJV were found to be hypoplastic, and in one case this was seen bilaterally in both the right and left IJV. The maximum depth of IJV from the skin was 27.9 mm. More than half (69.5%) of the IJV were less than 1 mm from the carotids. Computed tomography is an excellent method to delineate the anatomy of IJV. Variations in the anatomy of the IJV and their correlation to the CCA are common.     

Beta-thalassemia unlinked to the beta-globin gene in an English family

An inherited hypochromic microcytic anemia transmitted in an autosomal manner has been observed in three generations of an English family. Affected members had the hallmarks of heterozygous beta-thalassemia, ie, elevated levels of hemoglobin A2 and imbalanced globin chain synthesis. However, despite extensive sequence analysis, no mutations could be found in or around the beta-globin genes of either the propositus or two other affected members from two different generations. Linkage analysis using restriction fragment length polymorphisms in the beta-globin gene cluster clearly showed that the gene responsible for the beta-thalassemia phenotype segregates independently of the beta-gene complex. Therefore, this condition represents a novel form of the disease.