全文获取类型
收费全文 | 60588篇 |
免费 | 4593篇 |
国内免费 | 262篇 |
专业分类
耳鼻咽喉 | 560篇 |
儿科学 | 1860篇 |
妇产科学 | 1297篇 |
基础医学 | 8522篇 |
口腔科学 | 1018篇 |
临床医学 | 6380篇 |
内科学 | 12804篇 |
皮肤病学 | 1267篇 |
神经病学 | 6462篇 |
特种医学 | 1877篇 |
外国民族医学 | 11篇 |
外科学 | 7239篇 |
综合类 | 584篇 |
一般理论 | 67篇 |
预防医学 | 6080篇 |
眼科学 | 1014篇 |
药学 | 4059篇 |
1篇 | |
中国医学 | 132篇 |
肿瘤学 | 4209篇 |
出版年
2023年 | 685篇 |
2022年 | 1175篇 |
2021年 | 2164篇 |
2020年 | 1417篇 |
2019年 | 1881篇 |
2018年 | 2127篇 |
2017年 | 1654篇 |
2016年 | 1823篇 |
2015年 | 1922篇 |
2014年 | 2567篇 |
2013年 | 3122篇 |
2012年 | 4771篇 |
2011年 | 4894篇 |
2010年 | 2667篇 |
2009年 | 2229篇 |
2008年 | 3484篇 |
2007年 | 3564篇 |
2006年 | 3357篇 |
2005年 | 3000篇 |
2004年 | 2744篇 |
2003年 | 2317篇 |
2002年 | 2103篇 |
2001年 | 705篇 |
2000年 | 686篇 |
1999年 | 638篇 |
1998年 | 439篇 |
1997年 | 347篇 |
1996年 | 324篇 |
1995年 | 299篇 |
1994年 | 239篇 |
1993年 | 200篇 |
1992年 | 361篇 |
1991年 | 335篇 |
1990年 | 335篇 |
1989年 | 270篇 |
1988年 | 285篇 |
1987年 | 301篇 |
1986年 | 308篇 |
1985年 | 287篇 |
1984年 | 256篇 |
1983年 | 192篇 |
1982年 | 151篇 |
1981年 | 151篇 |
1980年 | 139篇 |
1979年 | 247篇 |
1978年 | 173篇 |
1977年 | 148篇 |
1976年 | 130篇 |
1974年 | 143篇 |
1973年 | 150篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
111.
Padmaja Yalamanchili Eric Wexler Megan Hayes Ming Yu Jody Bozek Mikhail Kagan Heike S. Radeke Michael Azure Ajay Purohit David S. Casebier Simon P. Robinson 《Journal of nuclear cardiology》2007,14(6):782-788
Background
BMS-747158-02 is a novel fluorine 18-labeled pyridazinone derivative designed for cardiac imaging. The uptake and retention
mechanisms of F-18 BMS-747158-02 in cardiac myocytes were studied in vitro, and the biodistribution of F-18 BMS-747158-02
was studied in vivo in mice.
Methods and Results
Fluorine 19 BMS-747158-01 inhibited mitochondrial complex I (MC-I) in bovine heart submitochondrial particles with an IC50 of 16.6±3 nmol/L that was comparable to the reference inhibitors of MC-1, rotenone, pyridaben, and deguelin (IC50 of 18.2±6.7 nmol/L, 19.8±2.6 nmol/L, and 23.1±1.5 nmol/L, respectively). F-18 BMS-747158-02 had high uptake in monolayers
of neonatal rat cardiomyocytes (10.3%±0.7% of incubated drug at 60 minutes) that was inhibited by 200 nmol/L of rotenone (91%±2%)
and deguelin (89%±3%). In contrast, an inactive pyridaben analog, P-0 (IC50 value>4 μmol/L in MC-1 assay), did not inhibit the binding of F-18 BMS-747158-02 in cardiomyocytes. Uptake and washout kinetics
for F-18 BMS-747158-02 in rat cardiomyocytes indicated that the time to half-maximal (t1/2) uptake was very rapid (approximately 35 seconds), and washout t1/2 for efflux of F-18 BMS-747158-02 was greater than 120 minutes. In vivo biodistribution studies in mice showed that F-18 BMS-747158-02
had substatial myocardial uptake (9.5%±0.5% of injected dose per gram) at 60 minutes and heart-to-lung and heart-to-liver
ratios of 14.1±2.5 and 8.3±0.5, respectively. Positron emission tomography imaging in the mouse allowed clear cardiac visualization
and demonstrated sustained myocardial uptake through 55 minutes.
Conclusions
F-18 BMS-747158-02 is a novel positron emission tomography cardiac tracer targeting MC-I in cardiomyocytes with rapid uptake
and slow washout. These characteristics allow fast and sustained accumulation in the heart. 相似文献
112.
Sequential 99mTc-hydrazinonicotinamide-annexin V imaging for predicting response to chemotherapy. 总被引:1,自引:0,他引:1
Sylvie Rottey Guido Slegers Simon Van Belle Ingeborg Goethals Christophe Van de Wiele 《Journal of nuclear medicine》2006,47(11):1813-1818
This study was undertaken to evaluate changes in relative (99m)Tc-hydrazinonicotinamide (HYNIC)-annexin V tumor uptake over time in patients undergoing chemotherapeutic treatment at baseline and at 5-7 h and 40-44 h after treatment initiation. Imaging results are related to clinical outcomes, as assessed with response evaluation criteria in solid tumors (RECIST). METHODS: We prospectively included 20 patients (11 men and 9 women; mean age, 59.8 y; range, 22-75 y) scheduled for chemotherapy (n = 19) or bisphosphonate treatment (n = 1). Curable disease was present in 5 patients. The other patients had metastatic disease and were treated in a palliative setting. Three of the 20 enrolled patients were excluded from analysis: 1 patient ultimately refused the proposed chemotherapy treatment; because of difficulties with the labeling procedure, 1 patient did not receive a pretreatment scan; and 1 patient presented with an allergic reaction (rash and nausea) to the (99m)Tc-HYNIC-annexin V formulation. The remaining 17 patients underwent 3 scintigraphic scans with (99m)Tc-HYNIC-annexin V: before treatment and 5-7 h and 40-44 h after treatment initiation. The tumor response was evaluated with RECIST and related to observed changes in the ratios of tumor activity to background activity for the largest known lesion; values exceeding 25% the baseline value on either the 5- to 7-h scan or the 40- to 44-h scan were considered significant. RESULTS: With the proposed sequential imaging protocol and a 25% change threshold, responders to treatment could be separated from nonresponders with a 94% accuracy (16/17 patients). CONCLUSION: Sequential (99m)Tc-HYNIC-annexin V imaging may allow for assessment of the response to chemotherapy within 3 d after treatment initiation. 相似文献
113.
Sara J White 《American journal of health-system pharmacy》2007,64(7):700, 702-700, 703
114.
115.
Qiang Tan Rudolf Steiner Simon P Hoerstrup Walter Weder 《European journal of cardio-thoracic surgery》2006,30(5):782-786
This review tries to summarize the efforts over the past 20 years to construct a tissue-engineered trachea. After illustrating the main technical bottlenecks faced nowadays, we discuss what might be the solutions to these bottlenecks. You may find out why the focus in this research field shifts dramatically from the construction of a tubular cartilage tissue to reepithelialization and revascularization of the prosthesis. In the end we propose a novel concept of 'in vivo bioreactor', defined as the design of a perfusion system inside the scaffold, and explain its potential application in the construction of a tissue-engineered trachea. 相似文献
116.
Overview Excess spasticity leads to disability that is marked by impaired locomotion, handicapping deformities and, if not controlled,
discomfort and pain. Selective peripheral neurotomy in the child is indicated for severe focal spasticity, when botulinum
toxin injections cannot delay surgery any longer.
Materials and methods Preoperative motor blocks mimicking the outcome of the surgical procedure are essential to establish the objectives of neurotomy.
In the lower limb, obturator neurotomy is indicated for spasticity in the adductor muscles, hamstring neurotomy for the knee flexion and tibial
neurotomy for the spastic foot. Anterior tibial neurotomy is indicated for the extensor hallucis spasticity and femoral neurotomy
for spasticity in the quadriceps. In the upper limb, neurotomy of the pectoralis major and teres major nerves is indicated for spasticity of the internal rotators of the shoulder.
Neurotomy of the musculocutaneous nerve is indicated for spasticity of the flexors of the elbow, and neurotomy of median and
ulnar nerves are indicated for spasticity of the pronators and flexors of the wrist and fingers.
Conclusion Selective peripheral neurotomy is a valuable neurosurgical procedure in well-trained surgical hands for severe focalised spasticity. 相似文献
117.
118.
Pietro Rubegni MD Sara Poggiali MD Aldo Cuccia MD Maurizio Biagioli MD Michele Fimiani MD 《Dermatologic surgery》2004,30(12P2):1539-1542
Background. Striated palmoplantar keratoderma or Brunauer-Fohs-Siemens syndrome is a very rare, focal, nonepidermolytic palmoplantar keratoderma with autosomal inheritance. Unlike other palmoplantar keratodermas, no association with visceral or skin cancer has ever been reported.
Objective. We report a case of malignant melanoma arising in the hyperkeratotic lesions on the right heel of a patient with striated palmoplantar keratoderma. The lesion was completely excised; our patient also underwent sentinel lymph node biopsy and then was treated with high-dose interferon adjuvant therapy.
Methods. Sentinel lymph node biopsy incision was made in elliptical fashion, long enough to harvest a full-thickness skin graft to cover the wide local excision defect. The skin graft was defatted by sharp dissection. Several perforations were made in graft and it was secured in place with sutures and bolster dressing.
Results. At follow-up, the grafted skin showed hyperkeratotic changes but no local or systemic signs of the disease was observed.
Conclusion. The association between striated palmoplantar keratoderma and acral melanoma is discussed. 相似文献
Objective. We report a case of malignant melanoma arising in the hyperkeratotic lesions on the right heel of a patient with striated palmoplantar keratoderma. The lesion was completely excised; our patient also underwent sentinel lymph node biopsy and then was treated with high-dose interferon adjuvant therapy.
Methods. Sentinel lymph node biopsy incision was made in elliptical fashion, long enough to harvest a full-thickness skin graft to cover the wide local excision defect. The skin graft was defatted by sharp dissection. Several perforations were made in graft and it was secured in place with sutures and bolster dressing.
Results. At follow-up, the grafted skin showed hyperkeratotic changes but no local or systemic signs of the disease was observed.
Conclusion. The association between striated palmoplantar keratoderma and acral melanoma is discussed. 相似文献
119.
This article focuses on possible psychopharmacological interventions in the immediate post disaster setting. As there is little evidence for the efficacy or effectiveness of such interventions-given the difficulty in performing randomized, double-blind, placebo controlled studies with these populations-the article will delineate the neurobiological basis for pathological sequelae and theoretical drug interventions targeting putative disease mechanisms. 相似文献
120.
A D Kofinas N V Simon K King D Clay J Deardorf 《Journal of ultrasound in medicine》1992,11(6):257-259
We examined 53 fetuses between 15 and 40 weeks of gestation with transverse and coronal sections of the head in order to evaluate the accuracy and reproducibility of the coronal cerebellar diameter. Intraobserver coefficient of variation was less than or equal to 2.2% and the mean interobserver difference was 2.2% (range, 0 to 6%). A positive linear correlation exists between transverse and coronal measurements (coronal diameter = 1.02 x transverse diameter - 0.48; R2 = 0.99; P less than 0.0001). We conclude that the coronal cerebellar diameter is reproducible and accurate and when indicated clinically can be used instead of the transverse cerebellar diameter when the latter is not obtainable because of fetal position. 相似文献