全文获取类型
收费全文 | 6420篇 |
免费 | 443篇 |
国内免费 | 74篇 |
专业分类
耳鼻咽喉 | 110篇 |
儿科学 | 180篇 |
妇产科学 | 89篇 |
基础医学 | 846篇 |
口腔科学 | 257篇 |
临床医学 | 511篇 |
内科学 | 1438篇 |
皮肤病学 | 214篇 |
神经病学 | 348篇 |
特种医学 | 399篇 |
外科学 | 944篇 |
综合类 | 36篇 |
预防医学 | 361篇 |
眼科学 | 161篇 |
药学 | 414篇 |
中国医学 | 64篇 |
肿瘤学 | 565篇 |
出版年
2024年 | 8篇 |
2023年 | 67篇 |
2022年 | 137篇 |
2021年 | 273篇 |
2020年 | 156篇 |
2019年 | 194篇 |
2018年 | 235篇 |
2017年 | 202篇 |
2016年 | 280篇 |
2015年 | 322篇 |
2014年 | 349篇 |
2013年 | 378篇 |
2012年 | 574篇 |
2011年 | 520篇 |
2010年 | 329篇 |
2009年 | 208篇 |
2008年 | 373篇 |
2007年 | 351篇 |
2006年 | 320篇 |
2005年 | 311篇 |
2004年 | 275篇 |
2003年 | 219篇 |
2002年 | 187篇 |
2001年 | 114篇 |
2000年 | 110篇 |
1999年 | 95篇 |
1998年 | 29篇 |
1997年 | 18篇 |
1996年 | 16篇 |
1995年 | 11篇 |
1994年 | 18篇 |
1993年 | 14篇 |
1992年 | 25篇 |
1991年 | 40篇 |
1990年 | 18篇 |
1989年 | 24篇 |
1988年 | 18篇 |
1987年 | 14篇 |
1986年 | 11篇 |
1985年 | 12篇 |
1982年 | 6篇 |
1981年 | 7篇 |
1980年 | 6篇 |
1979年 | 13篇 |
1978年 | 4篇 |
1974年 | 4篇 |
1973年 | 5篇 |
1972年 | 4篇 |
1970年 | 4篇 |
1966年 | 6篇 |
排序方式: 共有6937条查询结果,搜索用时 15 毫秒
991.
BACKGROUND: Management of arteriovenous malformations (AVMs) remains challenging because of their unpredictable behavior and high recurrence rate. A multidisciplinary approach based on a new classification scheme and improved diagnostic techniques may improve their management. The purpose of this study was to review our experience with combined embolotherapy, sclerotherapy (embolo/sclerotherapy), and surgical procedures to manage AVMs. METHODS: A total of 797 patients with congenital vascular malformations (January 1995 through December 2001) was investigated with noninvasive studies. Once an AVM was diagnosed, all underwent angiographic confirmation as a roadmap for treatment. Embolo/sclerotherapy and surgical procedures were instituted by the multidisciplinary team with periodic follow-up per protocol. Seventy-six patients with AVMs were reviewed retrospectively to assess the diagnosis and management by a multidisciplinary approach. RESULTS: Seventy-six (9.5% of all CVM) patients had AVMs, mostly infiltrating, extratruncular form (61/76). Embolo/sclerotherapy with various combinations of absolute ethanol, N-butyl cyanoacrylate (NBCA), contour particles, and coils were used in 48 patients. Sixteen patients with surgically accessible localized lesions completed preoperative embolism and sclerotherapy through 24 sessions, with subsequent surgical excision with minimal morbidity. Interim results were excellent, with no evidence of recurrence in all 16 patients with a mean follow-up of 24 months. Thirty-two patients with surgically inaccessible lesions (infiltrating) were treated with embolism and sclerotherapy alone. There were nine failures in a total of 171 sessions. Interim results with a mean of 19 months' follow-up of embolism and sclerotherapy alone were excellent in the majority (25/32) and good to fair among the rest (7/32). However, 31 complications, mostly minor (27/31), occurred in 30 sessions. Four major complications occurred, including facial nerve palsy, pulmonary embolism, deep vein thrombosis, and massive necrosis of an ear cartilage. CONCLUSIONS: Diagnosis and management of AVMs by a multidisciplinary approach that integrates surgical therapy with embolism and sclerotherapy appears to improve the results and management with limited morbidity and no recurrence during early follow-up. 相似文献
992.
Kien Gia To Michelle L. Fraser Dung Van Do Dat Van Duong Van-Anh Ngoc Huynh 《Ophthalmic epidemiology》2014,21(2):79-85
AbstractPurpose: To determine the prevalence of falls in the 12 months prior to cataract surgery and examine the associations between visual and other risk factors and falls among older bilateral cataract patients in Vietnam.Methods: Data collected from 413 patients in the week before scheduled cataract surgery included a questionnaire and three objective visual tests.Results: The outcome of interest was self-reported falls in the previous 12 months. A total of 13% (n?=?53) of bilateral cataract patients reported 60 falls within the previous 12 months. After adjusting for age, sex, race, employment status, comorbidities, medication usage, refractive management, living status and the three objective visual tests in the worse eye, women (odds ratio, OR, 4.64, 95% confidence interval, CI, 1.85–11.66), and those who lived alone (OR 4.51, 95% CI 1.44–14.14) were at increased risk of a fall. Those who reported a comorbidity were at decreased risk of a fall (OR 0.43, 95% CI 0.19–0.95). Contrast sensitivity (OR 0.31, 95% CI 0.10–0.95) was the only significant visual test associated with a fall. These results were similar for the better eye, except the presence of a comorbidity was not significant (OR 0.45, 95% CI 0.20–1.02). Again, contrast sensitivity was the only significant visual factor associated with a fall (OR 0.15, 95% CI 0.04–0.53).Conclusion: Bilateral cataract patients in Vietnam are potentially at high risk of falls and in need of falls prevention interventions. It may also be important for ophthalmologists and health professionals to consider contrast sensitivity measures when prioritizing cataract patients for surgery and assessing their risk of falls. 相似文献
993.
Levent T?k Mustafa Naz?ro?lu Salih Do?an Mehmet Cemal Kahya ?zlem T?k 《Indian journal of ophthalmology》2014,62(1):12-15
Introduction:
Melatonin has been considered a potent antioxidant that detoxifies a variety of reactive oxygen species in many pathophysiological states of eye. The present study was designed to determine the effects of Wi-Fi exposure on the lens oxidant, antioxidant redox systems, as well as the possible protective effects of melatonin on the lens injury induced by electromagnetic radiation (EMR).Materials and Methods:
Thirty-two rats were used in the current study and they were randomly divided into four equal groups as follows: First and second groups were cage-control and sham-control rats. Rats in third group were exposed to Wi-Fi (2.45 GHz) for duration of 60 min/day for 30 days. As in the third group, the fourth group was treated with melatonin. The one-hour exposure to irradiation in second, third and fourth took place at noon each day.Results:
Lipid peroxidation levels in the lens were slightly higher in third (Wi-Fi) group than in cage and sham control groups although their concentrations were significantly (P < 0.05) decreased by melatonin supplementation. Glutathione peroxidase (GSH-Px) activity was significantly (P < 0.05) lower in Wi-Fi group than in cage and sham control groups although GSH-Px (P < 0.01) and reduced glutathione (P < 0.05) values were significantly higher in Wi-Fi + melatonin group than in Wi-Fi group.Conclusions:
There are poor oxidative toxic effects of one hour of Wi-Fi exposure on the lens in the animals. However, melatonin supplementation in the lens seems to have protective effects on the oxidant system by modulation of GSH-Px activity. 相似文献994.
A Moradi Y J Sepah M A Ibrahim R Sophie C Moazez M G Bittencourt R E Annam M Hanout H Liu D Ferraz D V Do Q D Nguyen 《Eye (London, England)》2014,28(11):1315-1320
Purpose
The study aims to identify the association between the baseline retinal vascular calibre and visual outcome of patients with diabetic macular oedema (DMO) treated with intravitreal ranibizumab.Methods
The 1-M field (as defined in the ETDRS study) of the digital colour fundus photographs of DMO patients who had been treated primarily with ranibizumab in a clinical trial was assessed. Of the 84 patients, 25 had gradable retinal photographs that could be subjected to analyses by the Interactive Vessel Analysis (IVAN) software at baseline. The average retinal vascular calibre of the six largest venules (CRVE) and the six largest arterioles (CRAE) in the peripapillary area (0.5 and 1 disc diameter from the optic disc margin) was measured. The relationship between CRVE and CRAE at baseline and the change in visual acuity at month 12 was assessed using the Mann–Whitney U test.Results
Ten eyes from 10 patients who had shown an improvement of ≥2 lines of best corrected visual acuity (BCVA) at month 12 had a wider baseline CRVE (248.3±24.5 μm) compared with the 15 eyes from 15 patients who did not show the improvement of ≥2 lines (226.6±44.8 μm, P<0.05). The baseline CRAE did not differ significantly in these patients (156.1±22.7 vs 142±17.5 μm, P=0.17).Conclusions
A wider baseline retinal venular calibre may be a predictor of better visual outcome in DMO eyes treated with ranibizumab. Further prospective studies with a larger sample size and a broader range of disease severity and visual acuity are needed to confirm this finding. 相似文献995.
996.
Do Thi Ha Tran Thi Phuong Joonseok Oh KiHwan Bae Nguyen Duy Thuan MinKyun Na 《Phytotherapy research : PTR》2014,28(2):308-311
Paeonia suffruticosa has been traditionally employed for vitalizing blood circulation and alleviating liver and inflammatory diseases. The pathways by which palbinone (PB) isolated from P. suffruticosa mediates heme oxygenase‐1 (HO‐1) induction were investigated using the specific inhibitors for PI3K and mitogen activated protein kinases pathways. The effect of PB‐treatment on Nrf2 translocalization and HO‐1‐antioxidant response element (ARE) regulation was examined employing Western blot and luciferase assays. PB induced HO‐1 expression via the activation of Nrf2 in the hepatic cells, and ARE‐dependent genes were stimulated via the PB‐mediated Nrf2 activation. PB‐mediated HO‐1 expression could be involved with PI3K/Akt and ERK1/2 pathways. Our study suggests the mechanism by which PB induces HO‐1 expression in the hepatic cells. This might substantiate the traditional applications of P. suffruticosa for the treatment of oxidative stress‐related diseases including oxidant and inflammatory‐mediated vascular and liver diseases. Copyright © 2013 John Wiley & Sons, Ltd. 相似文献
997.
Thymus and activation‐regulated chemokine (TARC) can stimulate cancer cell proliferation and migration. The present study evaluated the clinical significance of serum TARC in gastric cancer (GC). We measured serum TARC, macrophage‐derived chemokine, monocyte chemotactic protein‐1 and stem cell factor (SCF) levels using a chemiluminescent immunoassay along the GC carcinogenesis (normal, high‐risk, early GC [EGC] and advanced GC [AGC]) in both training (N = 25 per group) and independent validation datasets (90 normal, 30 high‐risk, 50 EGC and 50 AGC). Serum levels were compared among groups using one‐way analysis of variance. To evaluate the diagnostic potential of serum TARC for GC, receiver operating characteristic curve and logistic regression analyses were performed. Correlations between serum TARC and GC clinicopathological features were analyzed using Spearman's correlation. In the training dataset, serum TARC correlated with serum MDC, MCP‐1 and SCF. However, only serum TARC and SCF were significantly higher in cancer groups than non‐cancer groups (P < 0.001). In the validation dataset, serum TARC also increased along the GC carcinogenesis; the AGC group (167.2 ± 111.1 ng/mL) had significantly higher levels than the EGC (109.1 ± 67.7 ng/mL), the high‐risk (66.2 ± 47.7 ng/mL) and the normal (67.5 ± 36.2 ng/mL) groups (Bonferroni, all P < 0.001). Receiver operating characteristic curves and logistic regression demonstrated the remarkable diagnostic potential of serum TARC as a single marker (72.0% sensitivity and 71.1% specificity; cutoff point, 0.37; logistic regression) and in a multiple‐marker panel (72.6% sensitivity and 88.2% specificity; cutoff point, 0.54). Spearman's correlation showed that serum TARC was closely correlated with tumor size (γs = 0.227, P = 0.028), T‐stage (γs = 0.340, P = 0.001), N‐stage (γs = 0.318, P = 0.002) and M‐stage (γs = 0.346, P = 0.001). Serum TARC is a promising serum biomarker for GC. 相似文献
998.
Sang-Hoon Ahn Do Joong Park Sang-Yong Son Chang-Min Lee Hyung-Ho Kim 《Gastric cancer》2014,17(2):392-396
Single-incision laparoscopic distal gastrectomy for early gastric cancer has recently been reported by a few centers in Korea and Japan. In this technical report, we describe the world’s first pure single-incision laparoscopic total gastrectomy with D1+beta lymph node dissection for proximal early gastric cancer. 相似文献
999.
Hee Jung Park Ji Yong Ahn Hwoon-Yong Jung Hyun Lim Jeong Hoon Lee Kwi-Sook Choi Do Hoon Kim Kee Don Choi Ho June Song Gin Hyug Lee Jin-Ho Kim 《Gastric cancer》2014,17(4):649-660
Background
There is little known about the clinicopathological features and the predictors of survival in extremely young adult patients aged 18–30 years. The aim of this study was to identify clinicopathological features and clinical outcomes for the overall population and for a resectable subgroup of gastric cancer patients aged 18–30 years.Methods
From January 2004 to December 2010, 207 patients aged between 18 and 30 years old were diagnosed with gastric cancer and treated at the Asan Medical Center. Clinical findings, histopathological parameters and outcomes were reviewed retrospectively. Patients were further divided into 2 groups according to tumor resectability and then clinicopathological factors that affect tumor resectability and clinical outcomes were analyzed.Results
Clinicopathological characteristics of study population showed a predominance of females, undifferentiated tumors, diffuse-type cancers, and advanced gastric cancer. The overall resectability rate was 70.0 % and the median follow-up period was significantly longer in the resectable tumor group (P < 0.001). Significant prognostic predictors for overall survival in overall patients were higher CEA levels (P = 0.016), larger tumor size (P < 0.001), unresectability (P = 0.006), and presence of lymphovascular invasion (P = 0.012) in a multivariate analysis. Significant prognostic factors for overall survival in patients with resectable disease included larger tumor size (>4 cm), lymphovascular invasion and higher CEA level in the multivariate analysis.Conclusions
Gastric adenocarcinomas in young adult patients aged 18–30 years have unique clinicopathological features. Early detection in a resectable state and subsequent complete resection could increase survival period in young patients with gastric cancer. 相似文献1000.
Ju-Hee Lee Sang-Yong Son Chang Min Lee Sang Hoon Ahn Do Joong Park Hyung-Ho Kim 《Gastric cancer》2014,17(3):529-536