全文获取类型
收费全文 | 1618篇 |
免费 | 122篇 |
国内免费 | 19篇 |
专业分类
耳鼻咽喉 | 4篇 |
儿科学 | 103篇 |
妇产科学 | 10篇 |
基础医学 | 167篇 |
口腔科学 | 94篇 |
临床医学 | 165篇 |
内科学 | 311篇 |
皮肤病学 | 63篇 |
神经病学 | 84篇 |
特种医学 | 248篇 |
外科学 | 193篇 |
综合类 | 41篇 |
一般理论 | 1篇 |
预防医学 | 83篇 |
眼科学 | 41篇 |
药学 | 68篇 |
1篇 | |
中国医学 | 3篇 |
肿瘤学 | 79篇 |
出版年
2023年 | 11篇 |
2022年 | 28篇 |
2021年 | 37篇 |
2020年 | 17篇 |
2019年 | 21篇 |
2018年 | 28篇 |
2017年 | 19篇 |
2016年 | 26篇 |
2015年 | 39篇 |
2014年 | 45篇 |
2013年 | 67篇 |
2012年 | 68篇 |
2011年 | 50篇 |
2010年 | 79篇 |
2009年 | 76篇 |
2008年 | 49篇 |
2007年 | 63篇 |
2006年 | 52篇 |
2005年 | 48篇 |
2004年 | 36篇 |
2003年 | 47篇 |
2002年 | 46篇 |
2001年 | 29篇 |
2000年 | 13篇 |
1999年 | 37篇 |
1998年 | 86篇 |
1997年 | 82篇 |
1996年 | 65篇 |
1995年 | 56篇 |
1994年 | 42篇 |
1993年 | 48篇 |
1992年 | 17篇 |
1991年 | 36篇 |
1990年 | 25篇 |
1989年 | 46篇 |
1988年 | 36篇 |
1987年 | 29篇 |
1986年 | 20篇 |
1985年 | 20篇 |
1984年 | 10篇 |
1983年 | 12篇 |
1982年 | 15篇 |
1981年 | 15篇 |
1980年 | 15篇 |
1979年 | 3篇 |
1978年 | 14篇 |
1977年 | 11篇 |
1976年 | 10篇 |
1975年 | 8篇 |
1946年 | 1篇 |
排序方式: 共有1759条查询结果,搜索用时 15 毫秒
91.
92.
93.
Haemorrhagic complications of pancreaticoduodenectomy 总被引:6,自引:0,他引:6
Balachandran P Sikora SS Raghavendra Rao RV Kumar A Saxena R Kapoor VK 《ANZ journal of surgery》2004,74(11):945-950
BACKGROUND: Haemorrhagic complication occurs in 5-16% of patients following pancreaticoduodenectomy (PD). We report an analysis of patients with post-PD bleed, to identify predictors of bleed, predictors of survival following bleed and the management of post-PD bleed. METHODS: Two hundred and eighteen patients with periampullary cancers underwent PD from 1989 to 2002. Forty-four (20.2%) patients had a bleeding complication. Of these, 25 patients had an intra-abdominal (IA) bleed and 21 had gastrointestinal (GI) bleed (two had both IA and GI bleed). Clinical, biochemical and tumour characteristics were analysed to identify factors influencing bleeding complications. RESULTS: The median time to presentation was 4.5 days (0-21 days). Serum bilirubin (P = 0.000, OR: 1.090) and pancreaticojejunostomy (PJ) leak (P = 0.009, OR: 3.174) were significant independent factors predicting bleeding complications. Forty-three per cent of patients each had early bleed (<48 h after PD) or delayed bleed (7 days after PD). Comparison of early and late bleeds showed that IA bleed (P = 0.02) presented as early bleeds. Male sex (P = 0.00) longer duration of jaundice (P = 0.02), PJ leak (P = 0.001), HJ leak (P = 0.001), duct to mucosa type of PJ anastomosis (P = 0.03) and IA abscess (P = 0.00) were associated with a significantly higher incidence of late bleeds. Overall mortality after PD was 9.6% with 34% and 3% in bleeders and non-bleeders, respectively. Septicaemia (P = 0.01, OR: 5.49), and acute renal failure (P = 0.01) were associated with increased mortality. CONCLUSIONS: Bleeding complications following PD were seen in one-fifth of patients and were associated with high mortality. Serum bilirubin levels and PJ leak were significant factors associated with bleeding complications. Septicaemia and acute renal failure were significant factors associated with mortality in the bleeders. 相似文献
94.
Omar F. Khabour Enas S. Alsatari Mohammad Azab Karem H. Alzoubi May F. Sadiq 《Environmental and molecular mutagenesis》2011,52(3):224-228
Tobacco smoking is a major world health problem. Recently, waterpipe smoking has become more popular in many countries. Although the genotoxicity associated with cigarette smoking has been extensively investigated, studies evaluating such toxicity in waterpipe users are still lacking. In this study, we examined the genotoxicity of waterpipe smoking in lymphocytes compared with the genotoxicity of cigarette smoking. Genotoxicity was evaluated using the sister chromatid exchanges (SCEs) assay. Fifty waterpipe smokers and 18 healthy nonsmokers participated in this study. Additionally, 18 heavy cigarette smokers (CS) were recruited for comparison. The results show that waterpipe smoking and cigarette smoking significantly increase the frequencies of SCEs (P < 0.01) compared with those of nonsmokers, indicating the genotoxic effect of tobacco smoking. In addition, frequencies of SCEs were significantly higher among waterpipe smokers compared with CS (P < 0.01), indicating that waterpipe smoking is more genotoxic than cigarette smoking. Moreover, the frequency of SCEs increased with the extent of waterpipe use. In conclusion, waterpipe smoking is genotoxic to lymphocytes and the magnitude of its genotoxicity is higher than that induced by regular cigarette smoking. Environ. Mol. Mutagen., 2011. © 2010 Wiley‐Liss, Inc. 相似文献
95.
Sameer M. Alarrayed Amgad E. El-Agroudy Ahmad S. Alarrayed Sumaya M. Al Ghareeb Taysir S. Garadah Salah Y. El-Sharqawi Ali H. Al-Aradi Balaji G. Dandi Sadiq Abdulla 《Clinical and experimental nephrology》2010,14(3):248-255
Background/aim
This observational study was conducted to evaluate the safety and efficacy of the conversion from calcineurin inhibitors (CNIs) to sirolimus (SRL)-based immunosuppressive therapy in kidney transplantation. 相似文献96.
97.
Omar Hayani Lyall AJ Higginson Baldwin Toye Ian G Burwash 《The Canadian journal of cardiology》2009,25(4):e130-e132
Infective endocarditis caused by zoonotic microorganisms is an uncommon clinical entity. A 55-year-old man was diagnosed with endocarditis due to Capnocytophaga canimorsus, a commensal bacterium contained in the saliva of dogs, that involved the aortic and tricuspid valves and was complicated by a para-aortic valve abscess and aorta-to-right atrial fistula. The patient was successfully treated with antibiotic therapy and surgical intervention. C canimorsus endocarditis should be considered in patients with culture-negative endocarditis, particularly in immunosuppressed, asplenic or alcoholic individuals who have recently suffered a dog bite or have had close contact with dogs. 相似文献
98.
Sadiq S Berndt TJ Nath KA Knox FG 《The Journal of laboratory and clinical medicine》2000,135(1):52-56
gamma-L-glutamyl-L-DOPA (gludopa) is a dopamine prodrug that is relatively specific for the kidney. Because dopamine is phosphaturic, the present study compared the phosphaturic effects of the infusion of equimolar doses of gludopa (n = 8), L-DOPA (n = 8), and gamma-L-glutamyl-L-tyrosine (glutyrosine, n = 6). Glutyrosine was used as a control to evaluate the effect of the glutamyl portion of gludopa on phosphate excretion. Sprague-Dawley rats (350 to 400 g) were anesthetized with 5-sec-butylethyl-2-thyobarbituric acid (Inactin; 100 mg/kg, IP) and underwent thyroparathyroidectomy. Clearances were taken during the infusion of normal saline vehicle, followed by the infusion of gludopa, L-DOPA, or glutyrosine, all infused at the rate of 10 nmol/kg bolus and 0.8 nmol/kg/min (iv). To determine the contribution of glutamyl derivative to phosphate excretion, gludopa or L-DOPA was infused in the presence of SCH23390, a DA-1 receptor antagonist. Gludopa infusion significantly increased dopamine excretion (from 1.9+/-0.2 ng/min to 17.0+/-3.9 ng/min, delta15.0+/-3.9 ng/min, P < .008) and fractional excretion of phosphate (from 2.6%+/-0.6% to 34.8%+/-1.8%, delta32.0%+/-1.6%, P < .001). L-DOPA infusion significantly increased dopamine excretion (from 1.4+/- 0.4 ng/min to 9.7+/-1.6 ng/min, delta8.3+/-1.5 ng/min, P < .001) and fractional excretion of phosphate (from 1.7%+/-0.6% to 8.2%+/-2.0%, delta6.4%+/-1.5%, P < .004). Glutyrosine infusion significantly increased fractional excretion of phosphate (from 2.8%+/-0.8% to 17.5%+/-5.2%, delta14.6%+/-4.8%, P < .03) without changing dopamine excretion (delta0.5+/-0.2 ng/min). Infusion of gludopa in the presence of SCH23390 increased fractional excretion of phosphate (from 5.7%+/-2.5% to 12.6%+/-3.5%, delta6.8%+/-2.3%, n = 6, P < .03), whereas SCH23390 completely blocked the phosphaturic effect of L-DOPA. We conclude that gamma-L-glutamyl-L-DOPA is more phosphaturic than L-DOPA in the rat because of the combined effects of dopamine and the glutamyl moiety. 相似文献
99.
100.
After the introduction of the colposcope for the examination of children suspected of being sexually abused in Leeds, a study was undertaken to describe the findings in detail. A total of 109 consecutive prepubertal girls, mean age 70.4 months were assessed including colposcopic genital and anal examination, and peer group review of reports and photographs. Fifty nine children had signs consistent with blunt force penetrating trauma (hymenal transection/major notch, scar, or hymenal attenuation). Transections were encountered most commonly at 6 o'clock (directly posterior). In 46 the hymenal orifice was gaping with thigh abduction only and in 47 the hymenal orifice transverse diameter was greater than 4 mm on labial separation. Overall, physical findings were commonly present and in only two cases were no signs recorded. Non-specific and frequent findings included patterns of labial and introital reddening. Supportive hymenal signs including swelling, rounding of edge, thickening, distortion, and loss of symmetry were common. Labial fusion was present in 20. Urethral dilatation with labial separation was noted in 14. Physical findings including normality are consistent with abuse and even minor anogenital signs as well as negative findings should be documented. Colposcopy and photography are valuable tools in peer review, teaching, and case management. 相似文献