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AIM: To study the in vivo anti-inflammatory activity of Tabernaemontana divaricata leaf extract on male albino mice. METHODS: Aqueous decoction and methanol leaf extracts were tested for their ability to reduce croton oil-induced edema in the mouse ear after topical application. The methanol leaf extract dose-dependently inhibited the croton oil-induced ear edema in mice (ID50 〈500 μg.cm-2). A bioassay-guided liquid-liquid fractionation of this methanol extract gave four active fractions: water insoluble (F1), hexane (F2), ethyl acetate (F3) and water (F4). RESULTS: The hexane fraction showed a very high activity (42.1% inhibition at 0.7 μg.cm-2) as compared to the control. The other fractions were less active (FI: 56.1% at 506.2 μg.cm-2; F3: 57.3% at 289.3 lag.cm-2; and F4: 31.9% for 203.8 μg.cm-2) while indomethacin gave 48.8% of inhibition at 90 μg-cm-2. The activity of F1 and F3 may be at least in part explained by the presence of anti-inflammatory flavonoids, while the activity was not correlated to the tannin contents. No compounds were detected in the most active F2 fraction. CONCLUSIONS: The results give a rational support to the traditional use of T. divaricata in tropical India as anti-inflammatory agent. 相似文献
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Increasingly pre-hospital trauma management involves transfer of patients using a scoop stretcher; a number of computed tomography (CT) compatible scoops have recently appeared on the market. We sought to evaluate any differences in image quality in polytrauma patients scanned in a scoop stretcher. CT studies of 234 consecutive patients presenting between December 2011 and August 2012 at our regional level 1 tertiary trauma centre were retrospectively reviewed. Patients were allocated into two groups: those scanned with a scoop stretcher and without. CTs were reviewed by a consultant radiologist and two senior radiology trainees and graded separately for quality/artefact. A scale of 1–5 was employed: 1—uninterpretable, 2—borderline image quality, 3—acceptable, 4—good, 5—excellent. A total of 128 (54.7 %) patients were scanned in a scoop stretcher and 106 (45.3 %) were scanned without, 183 males and 51 females (average age, 46 (16–94)?years; SD, 20). The average quality grading for the patients scanned in the scoop was 4.64 compared to 4.68 in those without the scoop. There was no significant grading difference between the groups, consultant (p?=?0.096) and trainees (p?=?0.782). No artefacts were attributable to the scoop stretcher 0/128 (0 %). Following our experience, the use of scoop stretchers is recommended for efficient, safe and practical management of trauma patients and in terms of imaging, with no detrimental effect on image quality. 相似文献
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Robert B. Schonberger MD MHS Amit Bardia MD Feng Dai PhD George Michel MS MBA David Yanez PhD Jeptha P. Curtis MD Michelle T. Vaughn MPH Matthew M. Burg PhD Michael Mathis MD Sachin Kheterpal MD MBA Shamsuddin Akhtar MD PhD Nirav Shah MD 《Journal of the American Geriatrics Society》2021,69(8):2195-2209
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Raad Mohamad Gorgis Sarah Abshire Chelsea Yost Monica Dabbagh Mohammed F Chehab Omar Aurora Lindsey Patel Sati Nona Paul Yan Jerry Singh Gurjit Syrjamaki John Kaatz Scott Parikh Sachin 《Journal of thrombosis and thrombolysis》2022,53(3):567-575
Journal of Thrombosis and Thrombolysis - Although certain risk factors have been associated with morbidity and mortality, validated emergency department (ED) derived risk prediction models specific... 相似文献
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Anoop Singh Nisar A. Mir Sachin Choudhary Deepika Singh Preetika Sharma Rajni Kant Indresh Kumar 《RSC advances》2018,8(28):15448
An efficient sequential multi-component method for the synthesis of N-arylpyrrole-3-carbaldehydes has been developed. This reaction involved a proline-catalyzed direct Mannich reaction-cyclization sequence between succinaldehyde and in situ generated Ar/HetAr/indolyl-imines, followed by IBX-mediated oxidative aromatization in one-pot operation. The practical utility of this procedure is shown at gram-scale and the synthesis of diverse bioactive fused heterocyclic scaffolds such as pyrroloquinoline, pyrrolo-oxadiazole, dihydro pyrroloquinoline, and pyrrolo-phenanthridine.An efficient sequential multi-component method for the synthesis of N-arylpyrrole-3-carbaldehydes has been developed. 相似文献