全文获取类型
收费全文 | 248篇 |
免费 | 11篇 |
国内免费 | 1篇 |
专业分类
儿科学 | 15篇 |
妇产科学 | 4篇 |
基础医学 | 30篇 |
口腔科学 | 4篇 |
临床医学 | 23篇 |
内科学 | 45篇 |
皮肤病学 | 3篇 |
神经病学 | 10篇 |
特种医学 | 14篇 |
外科学 | 45篇 |
综合类 | 11篇 |
一般理论 | 1篇 |
预防医学 | 15篇 |
药学 | 18篇 |
中国医学 | 7篇 |
肿瘤学 | 15篇 |
出版年
2024年 | 2篇 |
2023年 | 1篇 |
2022年 | 5篇 |
2021年 | 9篇 |
2020年 | 8篇 |
2019年 | 7篇 |
2018年 | 10篇 |
2017年 | 7篇 |
2016年 | 5篇 |
2015年 | 15篇 |
2014年 | 11篇 |
2013年 | 7篇 |
2012年 | 14篇 |
2011年 | 14篇 |
2010年 | 9篇 |
2009年 | 7篇 |
2008年 | 22篇 |
2007年 | 19篇 |
2006年 | 16篇 |
2005年 | 9篇 |
2004年 | 9篇 |
2003年 | 10篇 |
2002年 | 5篇 |
2001年 | 3篇 |
2000年 | 4篇 |
1999年 | 6篇 |
1998年 | 2篇 |
1997年 | 2篇 |
1991年 | 1篇 |
1987年 | 1篇 |
1986年 | 2篇 |
1984年 | 4篇 |
1983年 | 2篇 |
1981年 | 3篇 |
1980年 | 4篇 |
1978年 | 1篇 |
1972年 | 2篇 |
1971年 | 1篇 |
1970年 | 1篇 |
排序方式: 共有260条查询结果,搜索用时 110 毫秒
41.
Nakul?Gupta Anish?Patel Joe?Ensor Kamran?Ahrar Judy?Ahrar Alda?Tam Bruno?Odisio Stephen?Huang Ravi?Murthy Armeen?Mahvash Rony?Avritscher Stephen?McRae Sharjeel?Sabir Michael?Wallace Surena?Matin Sanjay?GuptaEmail author 《Cardiovascular and interventional radiology》2017,40(2):202-209
Purpose
To describe the incidence of multiple renal artery pseudoaneurysms (PSA) in patients referred for renal artery embolization following partial nephrectomy and to study its relationship to RENAL nephrometry scores.Materials and Methods
The medical records of 25 patients referred for renal artery embolization after partial nephrectomy were retrospectively reviewed for the following parameters: size and number of tumors, RENAL nephrometry scores, angiographic abnormalities, technical and clinical outcomes, and estimated glomerular filtration rates (eGFRs) after embolization.Results
Twenty-four patients had primary renal tumors, while 1 patient had a pancreatic tumor invading the kidney. Multiple tumors were resected in 4 patients. Most patients (92 %) were symptomatic, presenting with gross hematuria, flank pain, or both. Angiography revealed PSA with (n = 5) or without (n = 20) AV fistulae. Sixteen patients (64 %) had multiple PSA involving multiple renal vessels. Higher RENAL nephrometry scores were associated with an increasing likelihood of multiple PSA. Multiple vessels were embolized in 14 patients (56 %). Clinical success was achieved after one (n = 22) or two (n = 3) embolization sessions in all patients. Post-embolization eGFR values at different time points after embolization were not significantly different from the post-operative eGFR.Conclusion
A majority of patients requiring renal artery embolization following partial nephrectomy have multiple pseudoaneurysms, often requiring selective embolization of multiple vessels. Higher RENAL nephrometry score is associated with an increasing likelihood of multiple pseudoaneurysms. We found transarterial embolization to be a safe and effective treatment option with no long-term adverse effect on renal function in all but one patient with a solitary kidney.42.
43.
ABSTRACT: BACKGROUND: Cyclin-dependent kinase 4 (CDK4) together with its regulatory subunit cyclin D1, governs cell cycle progression through G1 phase. Cyclin-dependent kinase inhibitors, including p16INK4A in turn regulate CDK4. In particular, deregulation of the p16/CDK4/cyclin D1 complex has been established in a variety of human tumors including gliomas, sarcomas, melanoma, breast and colorectal cancer. However, changes in CDK4 have rarely been observed. METHOD: In this study we used a combination of PCR-SSCP and direct sequencing for mutational screening of CDK4. DNA was isolated from peripheral blood leukocyte of patients with squamous cell carcinoma of head and neck, for screening germline mutations in coding regions of CDK4. RESULTS: Variations observed in exon 2 and 5 were three missense mutations, g5051G > C (Ser52Thr), g5095G > C (Glu67Gln), g5906C > A, g5907C > G (Pro194Ser) and novel frame shift mutations g7321_23delTGA, g7121_7122insG, g7143delG in exon 7 and 3[PRIME]UTR respectively. CONCLUSION: In conclusion, two novel mutations were found in N terminal domain which indicates that CDK4 mutation may play a major role in the development and progression of squamous cell carcinoma of head and neck. 相似文献
44.
Zerin Hyder Wim Van Paesschen Ataf Sabir Francis H. Sansbury Katherine B. Burke Naz Khan Kate E. Chandler Nicola S. Cooper Ronnie Wright Edward McHale Hilde Van Esch Siddharth Banka 《European journal of human genetics : EJHG》2021,29(9):1377
ERBB4 encodes the tyrosine kinase receptor HER4, a critical regulator of normal cell function and neurodevelopmental processes in the brain. One of the key ligands of HER4 is neureglin-1 (NRG1), and the HER4-NRG1 signalling pathway is essential in neural crest cell migration, and neuronal differentiation. Pharmacological inactivation of HER4 has been shown to hasten the progression of epileptogenesis in rodent models, and heterozygous ERBB4 null mice are shown to have cognitive deficits and delayed motor development. Thus far there is only a single case report in the literature of a heterozygous ERBB4 deletion in a patient with intellectual disability (ID). We identified nine subjects from five unrelated families with chromosome 2q34 deletions, resulting in heterozygous intragenic loss of multiple exons of ERBB4, associated with either non-syndromic ID or generalised epilepsy. In one family, the deletion segregated with ID in five affected relatives. Overall, this case series further supports that haploinsufficiency of ERBB4 leads to non-syndromic intellectual disability or epilepsy.Subject terms: Chromosome abnormality, Genetic testing, Neurodevelopmental disorders 相似文献
45.
46.
Alorainy IA Sabir S Seidahmed MZ Farooqu HA Salih MA 《Journal of computer assisted tomography》2006,30(1):116-121
Joubert syndrome is often missed clinically and radiologically if not enough attention is paid to its subtle and variable clinical presentation and the imaging findings in the posterior fossa. The purpose of this paper is to illustrate the brain stem and cerebellar imaging findings in Joubert syndrome. Awareness of the clinical and neuroimaging findings in Joubert syndrome and maintenance of a high index of suspicion are essential to correctly diagnose this rare congenital malformation. 相似文献
47.
RATIONALE AND OBJECTIVES: To evaluate the correlation between image noise and body weight (BW) or body mass index (BMI) in coronary computed tomography angiography (CTA) as a potential parameter for reducing radiation dose in coronary CTA. MATERIALS AND METHODS: Thirty-six patients who underwent electrocardiogram-gated cardiac CT were analyzed in this study. The patients included 26 men and 10 women with a mean age of 60 years (range 43-79 years). All patients were imaged on a 16-row multidetector CT scanner. Mean value of BW and BMI was 83.5 kg and 28.1, respectively. Image noise was defined as standard deviation (SD) of the attenuation values measured by using 1 cm2 circular region of interest in the ascending aorta at the level of the right main pulmonary artery. The SD values were plotted against BW and BMI. The correlations were examined using a linear regression method. A P value of less than .05 was considered significant. RESULTS: The r value of linear regression between noise and BW was 0.90 (P < .001). The r value of linear regression between noise and BMI was 0.74 (P = .015). CONCLUSIONS: Excellent correlation was observed between noise and BW in coronary CTA. These data may be used as potential parameters for customized radiation dose modification to reduce radiation dose in coronary CT examinations. 相似文献
48.
49.
50.
Babor F Schuster F Mackenzie C Meisel R Schaper J Sabir H Siepermann M Wessalowski R Janßen G Borkhardt A Laws HJ 《Klinische P?diatrie》2012,224(3):160-165
Despite the implementation of new antifungal drugs, invasive aspergillosis (IA) still remains a considerable challenge in pediatric oncology with a severe mortality. Prophylactic and therapeutic measurement have to be evaluated in these rare but poor prognostic patients. Therefore the entire group of patients at risk of developing IA has to be defined before cooperative prospective trials. In a retrospective analysis including all our patients with malignancies we looked for patients with proven/probable IA. Cases of the period from 2003 to 2008 were analyzed in detail.In the period between 2003 to 2008 24 of 755 patients were affected by proven/ probable IA. Compared to former studies incidence increased from 1.3%in 1980 to 3.4% in 2008. AML patients with or without allogeneic/haploidentical stem cell transplantation were at highest risk (24% and 25% respectively, in comparison to 1% in ALL-patients). Survival after 2 years was 50% for patients with AML and IA. In patients with high risk to develop IA the effect of intensified, intravenous antimycotic prophylaxis has to be proven prospectively in a cooperative and randomized setting. 相似文献