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The maturation of IgM-expressing B cells to IgM-secreting plasma cells is
associated with both an increase in mu mRNA and the ratio of secreted to
membrane forms of mu mRNA. In contrast, previous studies demonstrated that
in vitro the secreted form of alpha mRNA (alpha s mRNA) predominates
regardless of the stage of B cell differentiation. The present study
demonstrates that alpha s mRNA predominates in both B cells derived from
the germinal centers of murine Peyer's patches and in the functional IgA
memory population, suggesting that in vitro events accurately represent the
generation of a secretory IgA response in vivo. Although the predominant
usage of the alpha s poly(A) site is due to RNA processing, it does not
depend on either the alpha s poly(A) site, the 3' splice site associated
with the exon encoding the membrane exon of IgA (alphaM) or the alphaM
poly(A) sites. Analysis of the sequence of the intron between the alpha s
terminus and alphaM (alpha s- alphaM intron) demonstrates the existence of
several potential regulatory elements. Furthermore, the effects of
deletions within the alpha s-alphaM intron on 3' terminus usage demonstrate
that the predominant usage of the proximal terminus is not strictly
dependent on the length of the intron. Together with previous work, these
observations support the idea that choice of 3' terminus for all Ig heavy
chain genes is regulated by a similar mechanism, but specific sequences
within a heavy chain gene can impinge upon that mechanism.
相似文献
137.
Giuseppe Mastrangelo Gianluca Marangi Maria N Ballarin Silvia Michilin Aline SC Fabricio Flavio Valentini John H Lange Ugo Fedeli Luca Cegolon Massimo Gion 《BMC public health》2011,11(1):220
Background
Osteopontin (OPN) is a plasma protein/cytokine produced in excess in several malignancies. In a recent study OPN was reported as being related to the duration of asbestos exposure and presence of benign asbestos-related diseases; however, it was unclear whether this protein was an indicator of exposure or effect. 相似文献138.
Trans Tasman Radiation Oncology Group Cancer Research: Phase III – Muscle Invasive Bladder Cancer trial (TROG 02.03): A moral dilemma
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![点击此处可从《Journal of Medical Imaging and Radiation Oncology》网站下载免费的PDF全文](/ch/ext_images/free.gif)
Nirdosh K Gogna FRCP FRANZCR Gillian Duchesne MD FRCR FRANZCR Peter O'Brien FRANZCR Nigel Spry FRCP FRANZCR PHD Sandra Turner FRANZCR John Matthews FRANZCR Martin Borg FRANZCR Kathryn Bauman B APP SC MED TECH Madeleine King PHD Elizabeth Burmeister MSC 《Journal of Medical Imaging and Radiation Oncology》2018,62(5):668-670
139.
BNBM PRASAD SHASHIREKHA SC TEWARI AS KASTHURI 《Medical Journal Armed Forces India》1998,54(2):134-136
Percutaneous catheter drainage was used to treat 12 among 34 cases of lung abscesses, who were refractory to medical therapy, severely ill and high risk cases for surgery. A complete clinical and radiological recovery was achieved in all the cases who underwent catheter drainage, thereby obviating the need for surgery. None of the cases had catheter or procedures related complications. From this study it is inferred that percutaneous transthoracic catheter drainage is a safe and an effective modality of therapy for patients with lung abscess in whom medical therapy has failed and those who are unsuitable for surgery.KEYWORDS: Lung abscess, Percutaneous catheter drainage 相似文献
140.