奶茶对大鼠体重和血清胆固醇含量的影响

目的 :探讨奶茶对大鼠体重和血清胆固醇含量的影响。方法 :将大鼠随机分为对照、脂对照、奶、茶和奶茶五组 ;高脂饲养的同时分别用水、奶、茶和奶茶进行灌胃 ,定期测定大鼠的血清胆固醇 (TC)。结果 :实验期间奶茶组大鼠体重的增长量高于其他三个高脂饲料组 ,且明显高于对照组 (P <0 .0 5 ) ;高脂饲料组大鼠的血清胆固醇含量明显增加 ,但增长量在高脂饲料组间差异无显著性 (P >0 .0 5 )。结论 :本实验浓度的奶茶对高脂饲料诱导的大鼠血清胆固醇升高未见有降低作用     

电针对大鼠海马兴奋性突触后电位长时程增强的作用

目的 观察电针对麻醉状态下正常和东莨菪碱引起的学习记忆减退模型大鼠海马突触EPSP长时程增强(LTP)的作用。方法 引导大鼠海马齿状回颗粒细胞层突触后兴奋性电位群(EPSPs)，强直刺激(HFS)大脑皮层前穿质区引起海马突触LTP反应；用东莨菪碱制备学习记忆障碍模型；观察电针大椎和肾俞穴对正常和模型大鼠海马LTP的影响。结果 电针对HFS诱发的海马突触LTP效应，其作用强于未电针组，部分参数和时段有统计学意义(P＜0．05)，且维持时间长于后者；东莨菪碱i．p可显著抑制HFS诱发的海马突触LTP(P＜0．01)，电针能显著对抗这一抑制作用(P＜0．01；P＜0．05)。结论 电针对HFS引起的海马突触LTP有一定的易化作用，并对东莨菪碱引起的学习记忆障碍有显著的对抗作用。     

Acute pericarditis as initial clinical manifestation of hypereosinophilia syndrome]

The case of a patient in whom acute pericarditis was the initial manifestation of an idiopathic hypereosinophilia is reported. Endomyocardial abnormalities were not found by echocardiography. Response to prednisone therapy was good; symptoms, pericardial effusion and eosinophilia early disappeared after therapy. Some clinical aspects of this uncommon disease are discussed.     

乳舒胶囊镇痛、抗炎作用研究

目的：研究乳舒胶囊(RS)的镇痛、抗炎药效。方法：采用RS灌胃给药后，分别用甩尾法、热板法、扭体法研究RS对乳腺增生模型大鼠及小鼠的镇痛作用，分别用二甲苯法、琼脂法研究RS抑制小鼠耳廓炎症及大鼠慢性炎症性肉芽肿的作用。结果：乳舒胶囊能提高乳腺增生模型大鼠和小鼠的痛阈值、能减少醋酸致扭体疼痛小鼠的扭体次数、延长其发生扭体的潜伏期，有明显的镇痛作用；还可以抑制琼脂所致的大鼠肉芽肿和二甲苯致小鼠耳肿胀，有明显的抗炎作用。结论：乳舒胶囊镇痛、抗炎作用明显、疗效确切。     

胶束电动毛细管色谱法测定复方酮康唑霜中酮康唑和特美呋的含量

目的:毛细管电泳法测定酮康唑霜中酮康唑和特美味的含量。方法:分离缓冲液为胆汁酸钠(70 mmol/L)-三羟甲基氨基甲烷-磷酸(50 mmol/L)(pH 8.14),分离电压30 kV、温度25 C、50 μm(内径)×48.5cm(有效长度40cm)空心熔融石英毛细管柱、检测波长240nm。结果:以丙酸睾酮为内标,酮康唑质量浓度在140.5～702.5 μg/ml、特美呋质量浓度在151～755μg/ml之间成良好的线性关系;加样回收率分别为95.4％～103.9％、95.9％～102.6％,RSD％分别为2.8％～4.2％(n=3)、2.9％～3.6％。结论:本法简便、快速、可靠,可用于该复方制剂中酮康唑及特美呋的含量测定。     

糖尿病酮症酸中毒诱因调查及防治对策

目的 :探讨糖尿病酮症酸中毒 (DKA)诱发因素的防治对策 ;方法 :采用计数方法间接确定住院的 57例DKA各种诱因的发生率 ,两组间进行对比分析 ,找寻诱因产生的根源 ;结果 :感染为诱因者 3 5例 ( 61 .4% ) ,用药不当 8例 ( 1 4 .0 % ) ,医源性因素 6例 ( 1 0 .5% ) ;感染诱因中呼吸道感染 2 3例 ( 65.7% ) ;病程一年以上者感染诱发率高于病程一年以下者 (P <0 .0 5) ,医源性诱因 1 0 0 %发生在病程一年以下且无糖尿病病史的 2型糖尿病 ;结论 :感染是DKA的首要诱发因素 ,严格控制血糖是减少感染发生率的必要手段 ,要避免用药不当这个主要诱因有赖于加强卫生宣教 ,取得患者在治疗上的配合 ;糖尿病的早期诊断可防止医源性诱因的发生     

A mixing model for polychlorinated dibenzo-p-dioxins and dibenzofurans in surface sediments from Newark Bay,New Jersey using polytopic vector analysis

The identity and relative contributions of various sources of polychlorinated dibenzo-p-dioxins (PCDDs) and dibenzofurans (PCDFs) to recently deposited sediments collected in Newark Bay and its major tributaries were determined using polytopic vector analysis (PVA), a multivariate statistical technique relatively new in the chemometric literature. The concentrations of 2,3,7,8-substituted PCDD/Fs were assayed in eighty-one surface and near-surface sediment samples collected from the Passaic River, Hackensack River, Arthur Kill, Elizabeth River, Kill Van Kull, Port Elizabeth, and Port Newark navigation channels and Robins Reef, which is located in New York Harbor. PVA modeling revealed five predominant 2,3,7,8-substituted PCDD/F fingerprint patterns in geographically plausible distributions throughout the estuary. This was consistent with the current understanding of hydrodynamic and sedimentation conditions reported in the literature for Newark Bay. Three patterns contained 2,3,7,8-tetrachlorodibenzo-p-dioxin (2,3,7,8-TCDD), which is alleged to originate from a single industrial source on the lower Passaic River. One of the fingerprints containing 2,3,7,8-TCDD was present in moderate proportions (10–20%) in surface sediments near the site, but was generally observed in low abundance (<5%) elsewhere in the estuary. A fingerprint pattern characteristic of PCDD/F profiles in effluents from municipal sewage and waste water treatment plants was widely distributed in the estuary, but reached its highest relative proportions in the Elizabeth River. A third fingerprint pattern was highest in the Arthur Kill and lower Passaic River and closely matched the residue patterns found in several types of combustion sources. A fourth finger-print pattern in Hackensack River and lower Passaic River sediment matched the PCDD/F profile reported in PCB Aroclor^® formulations. A fifth fingerprint pattern matched the profile in recycled pulp and paper mill effluents and was highest in Kill van Kull and upper Passaic River sediment. The majority of PCDD/Fs in sediment from Reaches B, C, and D of Port Newark and Port Elizabeth were attributable to sediments transported via the Arthur Kill and the Kill Van Kull. These results are consistent with those previously reported using principal components analysis, which indicated that 2,3,7,8-substituted PCDD/F patterns in the sediments of Newark Bay are consistent with discharges from multiple sources.     

Fulminant childhood hemophagocytic syndrome mimicking histiocytic medullary reticulosis. An atypical form of Epstein-Barr virus infection.

Ten cases of pediatric fulminant hemophagocytic syndrome, encountered between 1986 and 1989, are described. They occurred in the summer, and the patients presented with fever, jaundice, hepatosplenomegaly, pancytopenia, coagulopathy, and abnormal liver function. Bone marrow studies revealed infiltration by atypical T-lymphoid cells, rare B immunoblasts, and mature histiocytes with hemophagocytosis. Initially, histiocytic medullary reticulosis was suspected in six cases. The clinical course was characterized by rapid deterioration, with a mean period of 16 days from onset of fever to death. The main causes of death were coagulopathy with multiple organ failure and opportunistic infection. In seven of eight cases studied by serologic assay and Southern blot hybridization, acute or active Epstein-Barr virus (EBV) infection was documented. It is suggested that an atypical or fulminant form of primary EBV infection distinct from classic infectious mononucleosis was prevalent in previously healthy children in Taiwan. Younger age involvement and seasonal clustering were characteristic of the disorder described.     

人体中氧氟沙星的立体选择性代谢

５名健康志愿者日服单剂３００ｍｇ氧氟沙星［（±）－Ｏｆ１］后，采用立体选择性的ＲＰ－ＨＰＬＣ手性流动相添加剂法测定尿中Ｓ－（－）－Ｏｆ１和Ｒ－（＋）－Ｏｆ１浓度结果显示Ｏｆ１在人体内呈现立体选择性代谢。尿中排泄的Ｓ－（－）－Ｏｆ１／Ｒ－（＋）－Ｏｆ１之比随时间变化。服药后２ｈＳ／Ｒ是０．８７５，２４ｈ增加到１．１５０．Ｓ－（－）－Ｏｆ１的消除半衰期（ｔ１／２）是４．５７ｈ；消除速率常数（ｋ）是０．１５４ｈ；药时曲线下的面积（ＡＵＣ）为１．１７ｍｇ·ｈ－１．ｍＬ－１；Ｒ－（＋）－Ｏｆ１的ｔ１／２为４．１８ｈ，ｋ为０．１６８ｈ－１，ＡＵＣ是１．７８ｍｇ·ｈ－１·ｍＬ－１；经配对ｔ检验这三对参数间有显著性差异，Ｐ值分别小于０．０１，０．００１和０．００５．因此两对映体在人体内呈现立体选择性处置     

用阑尾作输出道的可控回肠膀胱术（附三例报告）

目的：探讨带血管蒂游离阑尾倒置与脐吻合作输出道的可控回肠膀胱术在膀胱癌手术中的应用效果。方法：3例膀胱移行上皮癌，均为多发、浸润肿瘤。男2例，女1例。年龄52－64岁，平均58岁。行根治性全膀胱切除术后，采用带血管蒂游离阑尾倒置与脐吻合作输出道，行可控回肠膀胱术。结果：全部患者手术顺利，3例均获随访，时间分别为8个月、15个月、26个月，效果满意，脐部造口隐蔽，导尿管插管排尿通畅，无尿外溢，1例有轻度双肾积水，血肌酐、尿素氮均正常。结论：带血管蒂游离阑尾倒置与脐吻合作输出道的可控回肠膀胱术是一种治疗中、晚期膀胱癌的较理想的手术方法。