茯苓萜类的高效液相色谱指纹图谱研究

目的 建立茯苓三萜化合物的指纹图谱。方法 反相高效液相色谱法。结果 道地药材茯苓及不同地区收集的市场商品具有相当稳定的、相似程度很高的指纹图谱。结论 可利用液相色谱的特征峰控制茯苓及其制剂的质量。     

白鲜皮质量标准研究

目的：为中药白鲜皮制定2005年版药典标准。方法：采用TLC法鉴别、反相高效液相色谱法测定白鲜皮中活性成分末梣酮含量，并对各地产白鲜皮药材的水分、总灰分、酸不溶性灰分、浸出物含量进行测定。结论：本方法操作简单，重现性好，可用于白鲜皮药材的质量控制。     

芳香疗法用于妇科恶性肿瘤患者术后恶心呕吐的效果研究

目的 探讨芳香疗法缓解妇科恶性肿瘤术后患者恶心呕吐的效果.方法 选取2019年1月至2019年8月间中国医学科学院肿瘤医院收治的行手术治疗的202例妇科恶性肿瘤患者,按病房号奇偶数随机分为试验组(102例)和对照组(100例).对照组患者采用常规护理,试验组患者在常规护理基础上采用嗅柠檬香氛作为芳香疗法进行干预,比较两...     

A systematic review of the efficacy of donepezil hydrochloride combined with nimodipine on treating vascular dementia

Background:Vascular dementia (VaD) is a comprehensive syndrome related to the damage of cognitive function and various cerebral vascular illnesses. VaD is also generally recognized as the second most common type of dementia after Alzheimer disease, contributing to 30% of the dementia population in Asia and developing countries. The ability of donepezil hydrochloride and nimodipine had been respectively proven in improving cognitive function in vascular dementia. However, whether the combined application of both drugs contribute to better efficacy remains as a research hotspot. Studies had shown definite satisfactory result with such combination, however evidence-based evaluation of the efficacy is still lacking. Therefore, meta-analysis is employed in this study to evaluate the efficacy and safety of using donepezil hydrochloride combined with nimodipine in treating VaD to provide references for clinical treatments. The efficacy of donepezil hydrochloride combined with nimodipine on treating vascular dementia is systematically reviewed to provide evidence-based references for clinical applications.Methods:Both Chinese and English databases were searched from the start till August, 2020 for any RCT regarding the combined use of the 2 drugs in treating vascular dementia. Two investigators would later evaluate and screened out research and data based on an improved Jaded scale. Software Rev Man 5.3.0 was employed to carry out meta-analysis on clinical effificacy, mini-mental state examination (MMSE) ratings, activity of daily living (ADL) ratings, and clinical dementia scale (CDR) ratings.Results:Donepezil hydrochloride combined with nimodipine had demonstrated satisfactory efficacy on the treatment of vascular dementia. Improvements were namely spotted on MMSE scale, ADL scale, and CDR scale, with the utmost efficacy by 12 weeks after intervention.Conclusions:Donepezil hydrochloride combined with nimodipine had good efficacy in the treatment of patients with vascular dementia, mainly in terms of improving the Simple MMSE scores, the ability to use daily living scale (ADL) scores and the CDR, and the best results were obtained after 12 weeks of intervention. Such conclusion should be cautiously evaluated.     

老年人心力衰竭91例临床分析

目的探讨老年人心力衰竭的临床特点。方法回顾性分析91例老年人心力衰竭临床资料,与21例中青年人心力衰竭进行对比分析。结果(1)随着年龄的增加,NYHA心功能Ⅲ、Ⅳ的比例显著增加;(2)引起心力衰竭前3位病因分别为冠心病(67.9%)、高血压病(32.1%)、肺心病(26.8%),老年组及高龄组常为2-3种疾病并存;(3)各年龄组心力衰竭最常见的诱因是感染(59.8%),高龄组心律失常(51.4%)也是重要的诱因;(4)老年及高龄组症状、体征常不典型,易致漏诊误诊;(5)高龄组并发脑梗死(25.7%)、心律失常-房颤(34.3%)及死亡(17.4%)的比例增加。结论年龄越大,临床表现越不典型,病情越危重,并发症越多,预后不良。     

红芪有效成分及“入脾经”相关药理研究

对近年来红芪的成分检测结果及其现代药理学研究成果进行了详细的综述,指出了中药红芪的主要成分,同时发现红芪的药理学研究结论符合其中医理论中的＂入脾经＂功效,并对两者相关性进行总结分析,为红芪的研究与开发提供依据。     

Acoustic triggered nanobomb for US imaging guided sonodynamic therapy and activating antitumor immunity

We fabricated an ultrasound activated ‘nanobomb’ as a noninvasive and targeted physical therapeutic strategy for sonodynamic therapy and priming cancer immunotherapy. This ‘nanobomb’ was rationally designed via the encapsulation of indocyanine green (ICG) and perfluoropentane (PFP) into cRGD peptide-functionalized nano-liposome. The resulting Lip-ICG-PFP-cRGD nanoparticle linked with cRGD peptide could actively targeted ID8 and TC-1 cells and elicits ROS-mediated apoptosis after triggered by low-intensity focused ultrasound (LIFU). Moreover, the phase change of PFP (from droplets to microbubbles) under LIFU irradiation can produce a large number of microbubbles, which act as intra-tumoral bomber and can detonate explode tumor cells by acoustic cavitation effect. Instant necrosis of tumor cells further induces the release of biologically active damage-associated molecular patterns (DAMPs) to facilitate antitumor immunity. More important, the ‘nanobomb’ in combination with anti-PD-1checkpoint blockade therapy can significantly improve the antitumor efficacy in a subcutaneous model. In addition, the liposomes may also be used as an imaging probe for ultrasound (US) imaging after being irradiated with LIFU. In summary, the US imaging-guided, LIFU activated ROS production and explosion ‘nanobomb’ might significantly improve the antitumor efficacy and overcome drug resistance through combination of SDT and immunotherapy, we believe that this is a promising approach for targeted therapy of solid tumor including ovarian cancer.     

Acute abdomen caused by torsion of the omentum: A pediatric case report

Rationale:Torsion of the omentum and infarction are rare and unusual disorders that often present as acute abdominal pain in the population. The diagnosis of omental torsion is based on clinical and imaging examinations.Patient concerns:A 7-year-old girl presented with acute right lower quadrant abdominal pain, with symptoms resembling acute appendicitis.Diagnosis:The patient was diagnosed with omental torsion based on imaging and laparoscopy.Interventions:Laparoscopic exploration was performed.Outcomes:The patient was discharged seven days after satisfactory postoperative recovery.Lessons:Omental torsion should be included in the differential diagnosis of acute abdominal pain, particularly in patients with free hemorrhagic fluid in the abdominal cavity and pelvis.     

头颈肿瘤游离皮瓣修复术后皮瓣坏死及皮瓣相关并发症影响因素分析

目的 分析皮瓣坏死及术后出现皮瓣相关并发症的影响因素。方法 回顾性分析因头颈肿瘤行游离皮瓣修复患者的年龄、性别、手术时长、吸烟、酗酒、高血压、糖尿病、术前放疗、血管吻合方式等对皮瓣坏死及皮瓣相关术后并发症的影响作用。结果 年龄、性别、手术时长、吸烟、酗酒、术前放疗、血管吻合方式不是头颈肿瘤患者游离皮瓣修复后皮瓣坏死及发生皮瓣相关术后并发症的危险因素;糖尿病是头颈肿瘤患者游离皮瓣修复后皮瓣坏死的危险因素(P=0.006),高血压(P=0.040)、糖尿病(P=0.024)是出现皮瓣相关术后并发症的独立危险因素。结论 在有游离皮瓣修复指征的头颈肿瘤但伴随有糖尿病、高血压疾病的患者中,经过全身情况评估后个体化选择修复方式。