A System of Local Analyzers for Noninvasive Diagnostics of the General State of the Tissue Microcirculation System of Human Skin

Biomedical Engineering - A system of wearable analyzers for simultaneous monitoring of blood microcirculation and oxidative metabolism in the tissue microcirculation system in several areas of the...     

Isoforms of Protein Kinase C and Their Distribution in Human Adrenal Cortex and Tumors

The cytosol and microsomal fractions of human adrenal cortex contain 3 isoforms of protein kinase C: a, z, and e. The latter fraction is present in trace amounts. No isoforms b1, b2, g and d were found in these cell fractions. The distribution of a-isoform between the cytosol and microsomal fraction is determined by tissue origin: in normal tissue its content differs by no more than 10%, while in most tumors this isoform is translocated into the microsomal fraction. The distribution of z-isoform did not depend on tissue origin.     

Bilateral tumors of the adrenal cortical substance

The results of surgical treatment of 4 patients with bilateral tumors of the adrenal cortical substance are presented. In 1 patient, glucosteronoma was revealed, in 2--malignant glucoandrosteronoma, in 1--nonfunctioning cancer. The patients with functioning tumors were operated on in two stages with the interval of 3-4 weeks. In 1 patient, 3 years after removal of the left adrenal gland for cancer, a tumor of the contralateral gland was removed. In removing the nonfunctional tumors and aldosteronomas, the median laparotomy is expedient, in glucosteronomas and glucoandrosteronomas--extraperitoneal lumbotomic approach. All the patients are alive 1.5-8 years after the operation.