Action of cell extract of Ehrlich's mouse ascites tumor on mitotic activity and DNA synthesis in that tumor

An extract of cells of Ehrlich's ascites tumor inhibits the proliferative activity of its cells tissue specifically. The effect is expressed as a marked decrease in the number of dividing and DNA-synthesizing cells after injection of the extract. The mitotic index falls considerably as early as 2 h after the injection, reaches a minimum after 4–5 h, and returns to the control level again after 9–12 h. The radioactive index is on the whole uniformly low during the 18 h of the experiment.Department of General Biology and Genetics, Medico-Biological Faculty, N. I. Pirogov Second Moscow Medical Institute. (Presented by Academician of the Academy of Medical Sciences of the USSR V. V. Kupriyanov.) Translated from Byulleten' Éksperimental'noi Biologii i Meditsiny, Vol. 84, No. 7, pp. 86–88, July, 1977.     

Comparative study of infusion therapy options in patients with hemorrhagic shock

This work presents the results of treatment of 60 patients with 2nd degree hemorrhagic shock at pre-hospital and hospital stages by different variations of infusion therapy. It is established that balanced infusion therapy in patients with 2nd degree hemorrhagic shock helps to stabilize the system hemodynamic and improve the general condition. The balanced infusion therapy does not lead to unfavorable changes in acid-alkaline and electrolyte balance.     

Simultaneous operations in patients with infrarenal aortic aneurism

During the period between 1982 and 2007 years, 125 patients had been simultaneously operated on the infrarenal atherosclerotic aortic aneurism (aorto-femoral by-pass) and other organs. 86 of them overcame simultaneous surgery considering vascular interventions, the rest 39 had been operated on general surgical and oncologic diseases of abdomen. The acquired results were satisfactory and proved the reasonability of simultaneous operations by aortic aneurism.     

Reoperations in thyroid gland cancer]

Results of reoperation for the thyroid gland cancer (THGC) were analyzed in 189 patients for 1981-2001 yrs period. Majority of patients were primarily operated in other hospitals of Ukraine. Thorough characteristic of the cancer forms, terms of reoperation performance, results of histological investigation of the tumor are adduced. Large frequency (41.2%) of the operation performance for THGC recurrences in term up to one years after performance of primary intervention trusts the necessity of operative intervention performance on thyroid gland (THG) in specialized centre by experienced surgeons. Absence of malignant growth in the THG stump while performance of definitive thyroidectomy in 60% of observations is not the cause to reject of doing it because the conduction of radioiodine therapy is possible after complete excision of the THG tissue. Examination and ultrasonographic investigation of the THG region and of cervical lymphatic nodes after performance of operation for THGC is recommended to conduct no less than once in 6 months.     

Side-to-end vs. straight stapled colorectal anastomosis after low anterior resection: results of randomized clinical trial

Aim

The aim of this study is to compare surgical, functional, physiologic outcomes and QOL after low anterior resection (LAR) with andside-to-end or straight colorectal anastomosis.

Method

Between 2012 and 2015, 86 patients with mid and low rectal tumors were enrolled into randomized trial. Wexner score, number of defecations, use of antidiarrheal medicine or laxatives, enemas, pads, episodes of nocturnal incontinence, and urgency were recorded. The Fecal Incontinence Quality of Life (FIQL) scale was used for assessment of QOL. Anal manometry and volumetric examination were performed.

Results

Six patients were excluded from the study. There was no mortality. The morbidity rate was 6 (14.6 %) for side-to-end vs. 8 (20.0 %) for straight anastomosis (p?=?0.57). The median Wexner score was 5 vs. 6 (p?=?0.033), 4 vs. 5 (p?=?0.006), and 2 vs. 3 (p?=?0.1) at 1, 3, and 6 months after stoma reversal, respectively. Side-to-end anastomosis resulted in a fewer mean numbers of bowel movements per day at the same check points of follow-up: 5.8?±?0.14 vs. 6.4?±?0.15 (p?=?0.006), 3.7?±?0.1 vs. 4.2?±?0.1 (p?=?0.003), and 2.5?±?0.1 vs. 3.0?±?0.10 (p?=?0.0002), correspondingly. Maximal tolerated volume was higher for side-to-end anastomosis at 3 and 6 months of follow-up: 152.0 vs. 137.8 cm³ (p?=?0.002) and 180.5 vs. 167.0 cm³ (p?=?0.006), respectively. Better FIQL score was found at 1 and 3 months in the side-to-end group.

Conclusion

Better functional outcomes and QOL were observed in a short period after stoma closure, but at 6 months of follow-up, the only benefit of side-to-end anastomosis was a lower number of bowel movements.

     

Effect of Bonnecor on clinical manifestations, bioelectric cardiac activity and cardiac hemodynamics in patients with acute myocardial infarction and chronic ischemic heart disease

Bonnecor treatment proved effective in arrest of ectopic excitation and is well tolerated by patients with acute myocardial infarction (AMI) and chronic coronary disease (CCD). Neither decline of arterial pressure nor inhibition of intracardiac hemodynamics was recorded. The main side effect manifested as prolongation of PQ interval. Bonnecor can be widely introduced in the treatment and prevention of extrasystolic arrhythmias in AMI and CCD patients.