丹参注射液治疗冠心病心绞痛临床观察

[目的]观察丹参注射液治疗冠心病心绞痛的疗效及安全性。[方法]将冠心病心绞痛患者100例随机分为两组,患者均予西医常规治疗,治疗组在对照组的基础上加丹参注射液静脉滴注,两组患者均治疗2周,观察综合疗效,并比较两组药物的安全性。[结果]两组患者症状、体征、心电图均有不同程度的好转,但治疗组与对照组有显著差异。[结论]丹参注射液结合西医常规治疗冠心病心绞痛有更显著的疗效,且无毒副作用。     

Different sensorimotor mechanism in fast and slow progression amyotrophic lateral sclerosis

The huge heterogeneity of the disease progression rate may cause inconsistent findings between local activity and functional connectivity of the primary sensorimotor area (PSMA) in amyotrophic lateral sclerosis (ALS). For illustration of this hypothesis, resting‐state fMRI (RS‐fMRI) data were collected and analyzed on 38 “definite” or “probable” ALS patients (19 fast and 19 slow, cut off median = 0.41) and 37 matched healthy controls. Amplitude of low frequency fluctuations (ALFFs) and functional connectivity strength (FCS) were analyzed within the PSMA. There was a decreased ALFF (p _FDR <.05) and FCS (p = .022) in all ALS patients. The two metrics shared about 50% of variance (R = .7) and both showed significant positive correlation with ALS Functional Rating Scale‐Revised (ALSFRS‐R) in the fast (p values <.034) but not in the slow progression groups. Interestingly, when regressing out the ALFF, the PSMA network FCS, especially the inter‐hemisphere FCS, showed negative correlation with the ALSFRS‐R score in the slow (R = −.54, p = .026) but not the fast progression group. In summary, the current results suggest that RS‐fMRI local activity and network functional connectivity accounts for the severity differently in the slow and fast progression ALS patients.     

周围动脉粥样硬化闭塞症胰岛素抵抗、内皮素、血管紧张素Ⅱ相互关系的研究

为探讨周围动脉粥样硬化闭塞症的胰岛素抵抗、内皮素、血管紧张素Ⅱ之间的相互关系,作者对32例本病患者进行糖耐量试验前后血糖、胰岛素水平测定,并计算其曲线下面积,同时采用放射免疫方法测定空腹血浆血管紧张素Ⅱ、内皮素含量,并分别与胰岛素及其曲线下面积作相关分析。结果表明,周围动脉粥样硬化闭塞症患者存在胰岛素抵抗,且糖耐量试验前后胰岛素水平及其曲线下面积均与血管紧张素Ⅱ、内皮素呈正相关系。提示胰岛素抵抗、血管紧张素Ⅱ、内皮素之间相互影响、相互促进、共同参与周围动脉粥样硬化闭塞症的形成和发展。     

Interstitial de novo deletion of the long arm of chromosome 5: Mapping of 5q bands associated with particular malformations

A new case of interstitial deletion of the long arm of one chromosome No. 5 (q13→q22) is described. The girl shows mental retardation, severe hypotonia, dysmorphic facies and peculiar dermatoglyphics. The relationship between partial trisomies and partial monosomies of 5q chromosomal segments and associated clinical features is discussed. It seems possible to draw a rough phenotypic map of the long arm of chromosome 5 (5q), correlating observed malformations and phenotypic features with specific chromosomal regions.