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11.
do Lago Eliel Scarpioni Ferreira Sabrina Garcia Idelmo Rangel Okamoto Roberta Mariano Ronaldo Clio 《Clinical oral investigations》2020,24(5):1637-1650
Clinical Oral Investigations - The effect of leucocyte- and platelet-rich fibrin (L-PRF), associated with DBBM (deproteinized bovine bone mineral; Bio-Oss®) was investigated and compared with... 相似文献
12.
Silvana Daher Costa Geraldo Bezerra da Silva Jr. Camilla Neves Jacinto Lorena Vasconcelos Mesquita Martiniano Yago Sucupira Amaral Fernando Jose Villar Nogueira Paes Maria Luiza De Mattos Brito Oliveira Sales Ronaldo de Matos Esmeraldo Elizabeth De Francesco Daher 《The American journal of tropical medicine and hygiene》2015,93(2):394-396
Few studies have focused on Rift Valley fever virus (RVFV) transmission in less arid, transitional landscapes surrounding known high-risk regions. The objective of this study was to identify evidence of RVFV exposure in Bodhei Village in a forested area at the edge of the RVFV-epidemic Garissa region. In a household cluster-based survey conducted between epidemics in early 2006, 211 participants were enrolled. Overall seroprevalence for anti-RVFV was high (18%) and comparable with rates in the more arid, dense brush regions farther north. Seroprevalence of adults was 28%, whereas that of children was significantly lower (3%; P < 0.001); the youngest positive child was age 3 years. Males were more likely to be seropositive than females (25% versus 11%; P < 0.01), and animal husbandry activities (birthing, sheltering, and butchering) were strongly associated with seropositivity. The results confirm that significant RVFV transmission occurs outside of recognized high-risk areas and independent of known epidemic periods. 相似文献
13.
Márcio Galindo Kiuchi MD Shaojie Chen MD PhD Bruno Rustum Andrea MD Tetsuaki Kiuchi MD Maria Angela Magalhães de Queiroz Carreira MD Miguel Luis Graciano MD PhD Jocemir Ronaldo Lugon MD PhD 《Journal of clinical hypertension (Greenwich, Conn.)》2014,16(11):794-800
Twenty‐seven patients with resistant hypertension and chronic kidney disease were treated by renal sympathetic denervation (RSD) and followed for 12 months. Patients were retrospectively divided into controlled and uncontrolled blood pressure (BP) groups. Increases in mean estimated glomerular filtration rate (eGFR) were found at months 1, 3, 6, and 12 in the controlled group (P<.0001, for every time point). The mean change in eGFR after 12 months was 18.54±8.15 mL/min/1.73m2 higher in the controlled group (P=.0318). In patients in the controlled group with baseline eGFR <45 mL/min/1.73 m2, responders (with an increase in eGFR >6.2%) corresponded to 50% at 6 months and 83% at 12 months. In the patients with baseline eGFR ≥45 mL/min/1.73 m2, all patients were labeled as responders at months 6 and 12. Median albumin:creatinine ratio after 12 months was lower than baseline only in the controlled group (P=.0003). Our results suggest that patients with this profile who reached BP control by RSD also experienced a significant improvement in renal function. 相似文献
14.
Aliani Moura Fonseca Angélica Rosa Faria Fernandes Tenório Gomes Rodrigues Ronaldo Alves Pinto Nagem Rubens Daniel Miserani Magalhães João Luís Reis Cunha Daniella Castanheira Bartholomeu Hélida Monteiro de Andrade 《Acta tropica》2014
Visceral leishmaniasis (VL) is a neglected disease and is fatal if untreated. Dogs serve as reservoirs for Leishmania infantum (syn. L. chagasi) due to their susceptibility to infection and high skin parasitism. Therefore, VL control in Brazil involves the elimination of seropositive dogs, among other actions. However, the most frequently used serological tests have limitations regarding sensitivity and specificity. In this study, we have selected three Leishmania antigens (C1, C8 and C9) and have produced them as recombinant proteins using pET-28a-TEV vector and Escherichia coli BL-21 as expression system. When tested in ELISA with human samples, the C9 antigen was the one showing the most promising results, with 68% sensitivity and 78% specificity. When testing canine samples, the C1, C8 and C9 antigens showed a sensitivity range from 70% to 80% and specificity range from 60% to 90%. The C1 antigen presented higher sensitivity (80%) and the C8 antigen presented higher specificity (90%). Due to it, we decided to mix and test C1 and C8 antigens together, resulting in the C18 antigen. The mix also yielded high percentages of detected symptomatic and asymptomatic dogs however it did not improve the performance of the diagnostic. Comparison of our tests with the tests recommended by the Brazilian Ministry of Health revealed that our antigens’ sensitivities and the percentage of detected asymptomatic dogs were much higher. Our results suggest that the C1, C8, C18 and C9 recombinant proteins are good antigens to diagnose canine visceral leishmaniasis and could potentially be used in screening tests. To diagnose human visceral leishmaniasis, the C9 antigen presented reasonable results, but more optimization must be performed for this antigen to provide better performance. 相似文献
15.
Sita C. Bennema Ronaldo Guilherme Carvalho Scholte Marcelo Beltr?o Molento Camilla Medeiros Omar dos Santos Carvalho 《Revista do Instituto de Medicina Tropical de S?o Paulo》2014,56(1):35-41
Fasciolosis is a disease of importance for both veterinary and public
health. For the first time, georeferenced prevalence data of Fasciola
hepatica in bovines were collected and mapped for the Brazilian territory
and data availability was discussed. Bovine fasciolosis in Brazil is monitored on a
Federal, State and Municipal level, and to improve monitoring it is essential to
combine the data collected on these three levels into one dataset. Data were
collected for 1032 municipalities where livers were condemned by the Federal
Inspection Service (MAPA/SIF) because of the presence of F.
hepatica. The information was distributed over 11 states: Espírito Santo,
Goiás, Minas Gerais, Mato Grosso do Sul, Mato Grosso, Pará, Paraná, Rio de Janeiro,
Rio Grande do Sul, Santa Catarina and São Paulo. The highest prevalence of
fasciolosis was observed in the southern states, with disease clusters along the
coast of Paraná and Santa Catarina and in Rio Grande do Sul. Also, temporal variation
of the prevalence was observed. The observed prevalence and the kriged prevalence
maps presented in this paper can assist both animal and human health workers in
estimating the risk of infection in their state or municipality. 相似文献
16.
17.
Thiago Ninck Valette Silvia Moreira Ayub-Ferreira Luiz Alberto Benvenuti Victor Sarli Issa Fernando Bacal Paulo Roberto Chizzola Germano Emilio Concei??o Souza Alfredo Inácio Fiorelli Ronaldo Honorato Barros dos Santos Edimar Alcides Bocchi 《Arquivos brasileiros de cardiologia》2014,102(5):505-509
Background
Discrepancies between pre and post-mortem diagnoses are reported in the literature, ranging from 4.1 to 49.8 % in cases referred for necropsy, with important impact on patient treatment.Objective
To analyze patients who died after cardiac transplantation and to compare the pre- and post-mortem diagnoses.Methods
Perform a review of medical records and analyze clinical data, comorbidities, immunosuppression regimen, laboratory tests, clinical cause of death and cause of death at the necropsy. Then, the clinical and necroscopic causes of death of each patient were compared.Results
48 deaths undergoing necropsy were analyzed during 2000-2010; 29 (60.4 %) had concordant clinical and necroscopic diagnoses, 16 (33.3%) had discordant diagnoses and three (6.3%) had unclear diagnoses. Among the discordant ones, 15 (31.3%) had possible impact on survival and one (2.1%) had no impact on survival. The main clinical misdiagnosis was infection, with five cases (26.7 % of discordant), followed by hyperacute rejection, with four cases (20 % of the discordant ones), and pulmonary thromboembolism, with three cases (13.3% of discordant ones).Conclusion
Discrepancies between clinical diagnosis and necroscopic findings are commonly found in cardiac transplantation. New strategies to improve clinical diagnosis should be made, considering the results of the necropsy, to improve the treatment of heart failure by heart transplantation. 相似文献18.
19.
20.
Makani H Messerli FH Romero J Wever-Pinzon O Korniyenko A Berrios RS Bangalore S 《The American journal of cardiology》2012,110(3):383-391
Angioedema is a rare, potentially life-threatening adverse event of renin-angiotensin system inhibitors. The objective of the present study was to determine the risk of angioedema from randomized clinical trials. A PubMed/CENTRAL/EMBASE search was made for randomized clinical trials from 1980 to October 2011 in patients on angiotensin-converting enzyme (ACE) inhibitors, angiotensin receptor blockers (ARBs), or direct renin inhibitor (DRI). Trials with a total number of patients ≥100 and a duration of ≥8 weeks were included for analysis. Incidence of angioedema was pooled by weighing the incident rate of each trial by the inverse of the variance. Twenty-six trials with 74,857 patients in the ACE inhibitor arm with 232,523 person-years of follow-up, 19 trials with 35,479 patients on ARB with 122,293 person-years of follow-up, and 2 trials with 5,141 patients on DRI with 1,735 person-years of follow-up met the inclusion criteria and were included in the analysis. In head-to-head comparison in 7 trials, risk of angioedema with ACE inhibitors was 2.2 times higher than with ARBs (95% confidence interval [CI] 1.5 to 3.3). With ACE inhibitors and ARBs, incidence of angioedema was higher in heart failure trials compared to hypertension or coronary artery disease trials without heart failure (p <0.0001). Weighted incidence of angioedema with ACE inhibitors was 0.30% (95% CI 0.28 to 0.32) compared to 0.11% (95% CI 0.09 to 0.13) with ARBs, 0.13% (95% CI 0.08 to 0.19) with DRIs, and 0.07% with placebo (95% CI 0.05 to 0.09). In conclusion, incidence of angioedema with ARBs and DRI was <1/2 than that with ACE inhibitors and not significantly different from placebo. Incidence of angioedema was higher in patients with heart failure compared to those without heart failure with ACE inhibitors and ARBs. 相似文献