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61.
Numerous extracellular proteins and glycosaminoglycans (GAGs) undergo limited enzymatic cleavage resulting in the release of fragments exerting biological activities, which are usually different from those of the full‐length molecules. In this review, we define matrikines and matricryptins, which are bioactive fragments released from the extracellular matrix proteins, proteoglycans and GAGs and report their major biological activities. These fragments regulate a number of physiopathological processes including angiogenesis, cancer, fibrosis, inflammation, neurodegenerative diseases and wound healing. The challenges to translate these fragments from molecules biologically active in vitro and in experimental models to potential drugs are discussed in the last part of the review. 相似文献
62.
Vladimir Carli Peter Parzer Camilla Wasserman Birgitta Floderus Alan Apter Judit Balazs Shira Barzilay Julio Bobes Romuald Brunner Paul Corcoran Doina Cosman Padraig Cotter Romain Despalins Nadja Graber Francis Guillemin Christian Haring Jean‐Pierre Kahn Laura Mandelli Dragan Marusic Gergely Mészáros George J. Musa Vita Postuvan Franz Resch Pilar A. Saiz Merike Sisask Airi Varnik Marco Sarchiapone Christina W. Hoven Danuta Wasserman 《Addiction (Abingdon, England)》2012,107(12):2210-2222
63.
Overweight and obesity are a worldwide burden still in expansion and are often related to an inappropriate nutrition and a lack of physical activity (PA). The therapeutic lifestyle change of these behaviours constitutes a cornerstone in the management of weight problem. However, it appears difficult to realize programme with the goal to motivate to PA, and consequently, to increase its levels of practice. Models of motivation and behaviour change have been elaborated to help people in their lifestyle behaviour change. Among these models, we wanted to introduce, describe a model of motivation and behaviour change: the transtheoretical model. Furthermore, we explained how to handle it in order to build therapeutics education interventions to motivate the practice of PA among persons with overweight and obesity. 相似文献
64.
Julie Weiss Romain Torrents Baptiste Verhamme Antoine Roch Pierre Lazerges Maeva Jego Pierre Michelet Nicolas Simon 《Fundamental & clinical pharmacology》2021,35(1):186-191
Chronic cannabis use can be associated with uncontrollable vomiting and abdominal pain. Diagnostic criteria for cannabinoid hyperemesis syndrome (CHS) were defined in 2012 by Simonetto et al. The objectives of this study were to describe the prevalence of CHS, the patients' epidemiological characteristics, and to show the difficulties encountered in caring for these patients in emergency departments, the extent of health care and an unsuitable follow‐up in general practices. A prospective cohort of patients with CHS was recruited among a target population of patients leaving the adult emergency services of the Marseille hospitals Nord and La Timone between October 2017 and July 2018, with abdominal pain syndrome of unidentified etiology. Inclusion criteria for the CHS cohort were chronic cannabis use associated with nausea and vomiting. There were 48 patients included in the CHS cohort who took cannabis daily, in a target population of 2 848 patients (i.e. 1.6%). A hot shower was the most effective symptomatic treatment in 54.2% of cases. Patients suffering from CHS spent significantly more hours in emergency departments (11 vs. 6.5), and, on average, visits were more frequent (4.9 vs. 3). 20.3% of them were hospitalized to continue pain medication. Once out of hospital, follow‐up was limited, and weaning off cannabis, the only etiological treatment, was difficult to set up. Informing patients about CHS is essential, and a hot shower could be systematically proposed, thus limiting an unnecessary extent of health care. CHS is genuine, medical staff should be made aware of it in occupational training, and it should be seriously considered in health policies. 相似文献
65.
Wing Chow Prina Donga Aurélie Côté-Sergent Carmine Rossi Patrick Lefebvre Marie-Hélène Lafeuille 《Current medical research and opinion》2020,36(8):1313-1323
Abstract
Objective
Evidence suggests that integrase strand transfer inhibitors (INSTIs) are associated with greater weight gain than other antiretrovirals. This real-world study compares weight/body mass index (BMI) change between insured US patients with human immunodeficiency virus (HIV-1) initiating a protease inhibitor (PI) or INSTI. 相似文献66.
67.
68.
Jacques-Olivier Bay Romain Guièze Aurélie Ravinet Richard Lemal Aliénor Xhaard Sébastien Bailly Cécile Moluçon-Chabrot Éric Hermet Julian Biau Pierre Verrelle Régis Peffault de Latour Olivier Tournilhac 《Bulletin du cancer》2013,100(6):587-599
Hematology Oncology has a rich history including few crucial therapeutic innovations. These were possible because of the evolution of the cell and molecular biology allowing a better understanding of basic mechanisms of cancerogenesis. We propose here to summarize the most important therapeutic innovations since the beginning of Hematology/Oncology history. We also describe evolution of therapeutic strategies themselves. New insights and therapeutic perspectives for next future are also discussed. 相似文献
69.
Chopard Romain Campia Umberto Morin Lucas Jering Karola S. Almarzooq Zaid I. Snyder Julia Elizabeth Rizzo Samantha Waxman Aaron B. Goldhaber Samuel Z. Piazza Gregory 《Journal of thrombosis and thrombolysis》2022,54(3):449-460
Journal of Thrombosis and Thrombolysis - Multidisciplinary pulmonary embolism (PE) response teams have garnered widespread adoption given the complexities of managing acute PE and provide a... 相似文献
70.
Goal‐directed behaviors in patients with schizophrenia: Concept relevance and updated model
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Goal‐directed behaviors are formulated to pursue a given objective by constructing a plan and selecting actions that lead to the intended goal, either immediately or over an extended period. This concept is important to the study of human behavior because of its involvement in the majority of complex or novel situations that an individual may encounter, regardless of the cognitive, affective, or social abilities required. In this paper, we aim to demonstrate the relevance of goal‐directed behaviors to our understanding of the cognitive deficits and other symptoms associated with schizophrenia. A systematic analysis of this relation may allow us to develop integrative hypotheses regarding positive, negative, and disorganized symptoms of schizophrenia rather than consider them to be distinct issues. In this article, we review previous studies of goal‐directed actions in patients with schizophrenia in order to clarify the relevant concepts and provide a theoretical basis for the integration of existing results. Based on available theoretical models and data, we propose an updated model to facilitate further investigation of schizophrenia‐related impairments in goal‐directed behaviors. 相似文献