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991.
Joost JC Verhoeff Olaf van Tellingen An Claes Lukas JA Stalpers Myra E van Linde Dirk J Richel William PJ Leenders Wouter R van Furth 《BMC cancer》2009,9(1):444
Background
The relevance of angiogenesis inhibition in the treatment of glioblastoma multiforme (GBM) should be considered in the unique context of malignant brain tumours. Although patients benefit greatly from reduced cerebral oedema and intracranial pressure, this important clinical improvement on its own may not be considered as an anti-tumour effect. 相似文献992.
993.
HUBERT COCHET M.D. Ph.D. DANIEL SCHERR M.D. STEPHAN ZELLERHOFF FREDERIC SACHER M.D. NICOLAS DERVAL M.D. ARNAUD DENIS M.D. SEBASTIEN KNECHT M.D. YUKI KOMATSU M.D. MICHEL MONTAUDON M.D. Ph.D. FRANÇOIS LAURENT M.D. BURKERT M. PIESKE M.D. MÉLÈZE HOCINI M.D. MICHEL HAÏSSAGUERRE M.D. PIERRE JAÏS M.D. Ph.D. 《Journal of cardiovascular electrophysiology》2014,25(7):671-679
994.
JA Dodge 《Acta paediatrica (Oslo, Norway : 1992)》1999,88(S432):28-32
Cystic fibrosis (CF) is relatively common, serious, and causes progressive lung damage. Clinical diagnosis may be delayed until lung damage has occurred, and infection may start as early as six weeks of life. A well organised screening programme should identify the great majority of affected infants within the first three weeks after birth, which leaves a small time window during which effective preventive treatment and surveillance may be instituted. Active treatment, whether for screened or unscreened infants, improves clinical status and long-term survival of CF patients. It is anticipated that new treatments will become available within the next few years, and these will clearly give maximal benefit to young infants if instituted before lung damage is evident. In addition to any hypothetical effects on morbidity and survival, pre-symptomatic diagnosis greatly improves the doctor-parent relationship. Economic arguments may be distorted, but, at best, screening is cost-beneficial, and, at worst, it is cost-neutral. The overwhelming majority of CF professionals and parents universally support neonatal screening, so the onus is therefore on those who oppose screening to prove that their approach offers a superior strategy. 相似文献
995.
GJ Timmers MD THM Falke MD PhD JA Rauwerda MD PhD PC Huijgens MD PhD 《International journal of clinical practice》1999,53(1):75-76
Intrahepatic interruption of the inferior vena cava is a congenital anomaly, resulting in venous drainage of the lower extremities by way of a compensatory enlarged vena azygos system. We report the case of a 37-year-old male who presented with symptoms of deep vein thrombosis of the entire right lower extremity. A right-sided mediastinal mass on the chest X-ray was mistaken for a haematological malignancy but proved later to represent an enlarged azygos vein. The case illustrates that in a case of deep vein thrombosis, especially in younger patients, interruption of the inferior vena cava should be considered. A right-sided paratracheal mass on the chest X-ray may give a clue in making the correct diagnosis. 相似文献
996.
997.
Molecular refinement of the 1p36 deletion syndrome reveals size diversity and a preponderance of maternally derived deletions 总被引:8,自引:0,他引:8
Wu YQ; Heilstedt HA; Bedell JA; May KM; Starkey DE; McPherson JD; Shapira SK; Shaffer LG 《Human molecular genetics》1999,8(2):313-321
The deletion of chromosome 1p36 is a newly recognized, relatively common
contiguous gene deletion syndrome with a variable phenotype. The clinical
features have recently been delineated and molecular analysis indicates
that the prevalence of certain phenotypic features appears to correlate
with deletion size. Phenotype/genotype comparisons have allowed the
assignment of certain clinical features to specific deletion intervals,
significantly narrowing the regions within which to search for candidate
genes. We have extensively characterized the deletion regions in 30 cases
using microsatellite markers and fluorescence in situ hybridization
analyses. The map order of 28 microsatellite markers spanning the deletion
region was obtained by a combination of genotypic analysis and physical
mapping. The deletion region was divided into six intervals and breakpoints
were found to cluster in mainly two regions. Molecular analysis of the
deletions showed that two patients had complex re-arrangements; these cases
shared their distal and proximal breakpoints in the two common breakpoint
regions. Of the de novo deletions ( n = 28) in whichparental samples were
available and the analysis was informative ( n = 27), there were
significantly morematernally derived deletions ( n = 21) than paternally
derived deletions ( n = 6) (chi1(2) = 8.35, P < 0.0001).
Phenotype/genotype correlations and refinements of critical regions in our
naturally occurring deletion panel have delineated specific areas in which
to focus the search for the causative genes for the features of this
syndrome.
相似文献
998.
We report a case of renal capsular artery pseudoaneurysm caused by percutaneous renal biopsy. The injury was diagnosed and treated with arteriography and transarterial embolization. Because the arterial injury was extraparenchymal, the clinical manifestations of blood loss were flank pain and decreasing hematocrit without hematuria. Injury to renal capsular arteries during percutaneous renal biopsy is a rare possibility because of their small size. 相似文献
999.
Circulating eosinophil/basophil progenitors and nasal mucosal cytokines in seasonal allergic rhinitis 总被引:3,自引:0,他引:3
M Linden C Svensson M Andersson L Greiff E Andersson JA Denburg CGA Persson 《Allergy》1999,54(3):212-219
Accumulation of eosinophils in the airways is characteristic of allergic rhinitis and asthma. The tissue eosinophilia may involve both recruitment of mature eosinophils and proliferation of their progenitors. This study examines mature eosinophils (nasal and circulating), their circulating progenitors, and a potential role of granulocyte-macrophage colony-stimulating factor (GM-CSF) in stimulating these progenitors. Twelve subjects with a history of seasonal allergic rhinitis and positive skin prick test for birch pollen were studied during four periods: shortly before, in the early and intense phase, at the end, and well after the Swedish birch-pollen season. Nasal mucosal and circulating eosinophils were examined in both nasal brushings and peripheral blood samples. Eosinophil/basophil progenitors were determined by counting colony-forming units in nonadherent mononuclear blood-cell cultures in methylcellulose at 14 days. The nasal mucosal cytokines GM-CSF, interleukin (IL)-1beta, IL-3, IL-5, IL-6, IL-8, and RANTES were analyzed (ELISA) in nasal lavage (NAL) fluids. All patients developed severe symptoms of rhinitis at the height of the season, with increased numbers of eosinophils in the nasal mucosa (P<0.05) and in the circulation (P<0.05). At this time point, the number of circulating progenitors (P<0.05) and the NAL fluid level of GM-CSF (P<0.05) were also increased. In contrast, there was no change in the NAL fluid levels of IL-1beta, IL-3, IL-6, or IL-8. Neither IL-5 nor RANTES could be detected in any of the NAL fluids. At the end of or after the season, there was no increase in nasal eosinophils or circulating eosinophils or progenitors (P>0.05). Ex vivo addition of GM-CSF (10-100 U) increased the number of blood progenitors grown before (P<0.01) and after (P<0.05) the season, compared with during the season. The in vitro GM-CSF responsiveness of progenitors may be related to whether or not these already have been stimulated endogenously by GM-CSF. Taken together, our data thus suggest that GM-CSF may play a role in vivo to increase production of eosinophilic progenitors in allergic airway disease. 相似文献
1000.
目的分析创伤性动静脉瘘(AVF)的临床特点、造影表现、造影技术及治疗方式的选择。方法回顾性分析纽约Kings County医疗中心25年间全部确诊的108例创伤性AVF的介入相关诊疗资料。分析内容包括患者外伤种类、临床表现、损伤部位、血管造影异常特征、AVF血流动力学特征(分5个类型)、治疗方式的选择等。结果 108例患者中共发现117处AVF,大多数患者临床特征不明确。创伤种类包括枪伤(导致72处AVF)、刺伤(24处)、钝性伤(8处)、高处坠落伤(3处)、医源性损伤(2处)。损伤部位常见于肢体(46例)、颈部(19例)、肝脏(13例)和锁骨下血管(11例)。所有病变均可见静脉早显,显示动脉横断52处,撕裂37处,49.6%的AVF与假性动脉瘤有关。最常见的血流特点是Ⅰ型,即瘘口所在的动脉近段和远段、静脉的近段和远段都显示,伴远侧段静脉瓣功能不全,共40处瘘(34.2%),其次是Ⅲ型22个(18.8%),Ⅴ型最不常见(4.3%)。34例接受手术治疗,61例栓塞治疗,7例临床观察。分别采用弹簧圈(47例)、明胶海绵(9例)、无水乙醇(3例)、可脱球囊(2例),其中弹簧圈效果理想、并发症少。6例采用覆膜支架效果好。结论血管造影是诊断创伤性AVF的金标准,造影时准确观察动脉损伤的性质,瘘口的解剖和血流特点及所有进入瘘口的动脉分支,对于选择治疗方式及保证介入治疗的成功完成至关重要。 相似文献