全文获取类型
收费全文 | 111055篇 |
免费 | 8025篇 |
国内免费 | 526篇 |
专业分类
耳鼻咽喉 | 1388篇 |
儿科学 | 2763篇 |
妇产科学 | 1689篇 |
基础医学 | 14496篇 |
口腔科学 | 2503篇 |
临床医学 | 11411篇 |
内科学 | 24205篇 |
皮肤病学 | 1773篇 |
神经病学 | 10845篇 |
特种医学 | 4339篇 |
外国民族医学 | 3篇 |
外科学 | 17639篇 |
综合类 | 947篇 |
一般理论 | 204篇 |
预防医学 | 8178篇 |
眼科学 | 2188篇 |
药学 | 6805篇 |
中国医学 | 167篇 |
肿瘤学 | 8063篇 |
出版年
2023年 | 855篇 |
2022年 | 1056篇 |
2021年 | 3683篇 |
2020年 | 2031篇 |
2019年 | 3166篇 |
2018年 | 3677篇 |
2017年 | 2653篇 |
2016年 | 2858篇 |
2015年 | 3203篇 |
2014年 | 4470篇 |
2013年 | 5770篇 |
2012年 | 8787篇 |
2011年 | 8934篇 |
2010年 | 4858篇 |
2009年 | 4286篇 |
2008年 | 7352篇 |
2007年 | 7147篇 |
2006年 | 6935篇 |
2005年 | 6838篇 |
2004年 | 6251篇 |
2003年 | 5723篇 |
2002年 | 5144篇 |
2001年 | 772篇 |
2000年 | 611篇 |
1999年 | 855篇 |
1998年 | 1062篇 |
1997年 | 838篇 |
1996年 | 707篇 |
1995年 | 677篇 |
1994年 | 544篇 |
1993年 | 550篇 |
1992年 | 450篇 |
1991年 | 427篇 |
1990年 | 378篇 |
1989年 | 363篇 |
1988年 | 368篇 |
1987年 | 352篇 |
1986年 | 380篇 |
1985年 | 363篇 |
1984年 | 424篇 |
1983年 | 361篇 |
1982年 | 386篇 |
1981年 | 390篇 |
1980年 | 315篇 |
1979年 | 193篇 |
1978年 | 221篇 |
1977年 | 204篇 |
1976年 | 160篇 |
1975年 | 175篇 |
1974年 | 160篇 |
排序方式: 共有10000条查询结果,搜索用时 156 毫秒
81.
82.
Frances J. Mather Richard M. Simon Gary M. Clark Daniel D. 《Statistics in medicine》1990,9(9):1118-1118
83.
A prospective, randomized controlled study of computer-assisted learning in parasitology. 总被引:1,自引:0,他引:1
PURPOSE: To compare, using a prospective, randomized controlled study, three methods of teaching a medical school parasitology course: computer-based instruction, traditional lecture-based instruction, and a combination of computer-based and lecture-based instruction. METHOD: A single class of the University of Utah School of Medicine was randomized into three study groups for the second-year parasitology course. The computer group (n = 29) used a locally developed interactive parasitology computer program; the lecture group (n = 32) had traditional lectures, and the combined group (n = 33) used both the computer program and lectures. Students' knowledge was assessed using a pretest, a final examination, and a posttest administered four months after the course. Students also used logs to track the amounts of time they spent studying. Their impressions and course evaluations were collected using a standardized course-evaluation form. RESULTS: The groups' scores on the pretest, final examination, and posttest were not statistically significantly different. Students in the computer group averaged 26.8 hours of studying over the two-week course compared with 32.1 hours in the lecture group and 32.7 hours in the combined group. The difference in study times between the computer and combined groups yielded a significant p value of 0.036. Students were generally positive about the course and the computer program. CONCLUSION: Students can learn parasitology from computer-based instruction as effectively as from traditional lecture-based instruction, and they can do so in less time. 相似文献
84.
Tauseef Ahmed Alan Yagoda Howard I. Scher Cora Sternberg Robin C. Watson 《Investigational new drugs》1986,4(2):171-174
Summary Deaza-aminopterin is a folate analog which is transported more rapidly than methotrexate into cells and appears to be more active than methotrexate against human and animal tumor in vitro. Fifteen patients with advanced urothelial tract cancer were given deaza-aminopterin 30–37.5 mg/m2 IV QW. In responding patients drug was given QOW after 4–6 consecutive doses. Doses were escalated or de-escalated by 7.5 mg/m2 depending on toxicity. Twelve patients had received prior chemotherapy which included methotrexate in nine. Three patients achieved a partial remission lasting 1, 3, and 3 months respectively: all responders had previously failed methotrexate after an initial response to a methotrexate containing regimen. None of the six patients who were methotrexate naive responded to deaza-aminopterin; 3 subsequently received methotrexate without response. Mild mucositis was universal and in 5 was severe. Six patients had an increase in liver transaminases probably secondary to anti-folate hepatotoxicity. Other toxicities included diarrhea, nausea, skin rash and fever. Further studies are needed to define the precise efficacy of deaza-aminopterin in patients with urothelial tract cancers. 相似文献
85.
Three evaluation instruments (global, check-list, and criterion referenced) were used by experienced and inexperienced examiners to evaluate dental sealant end products on 40 extracted teeth. Intra- and interexaminer reliabilities were measured. Experienced examiners achieved higher intrarater reliabilities with all three evaluation instruments than did inexperienced examiners. The highest intraexaminer agreement for all examiners occurred with use of the global evaluation. The highest interexaminer reliability was achieved with the second use of the criterion-referenced evaluation by the experienced examiner. Interexaminer reliability was improved for both types of examiners with the criterion-referenced evaluation. 相似文献
86.
87.
丹尼尔·秦 《中华医学教育杂志》2002,(4):3
<西太平洋地区本科医学教育指导原则>为医学院校提供了基准和质量改进的努力方向,并将有助于实现可持续的课程改革.本次会议将是中国在改善本科医学教育质量上迈出的重要一步.世界卫生组织愿与中国政府合作并提供支持. 相似文献
88.
Patients with Fabry disease on dialysis in the United States. 总被引:9,自引:0,他引:9
Ravi Thadhani Myles Wolf Michael L West Marcello Tonelli Robin Ruthazer Gregory M Pastores Gregorio T Obrador 《Kidney international》2002,61(1):249-255
BACKGROUND.: Fabry disease results from an X-linked deficiency of lysosomal alpha-galactosidase A and is a rare cause of end-stage renal disease. Little is known about the characteristics of patients with Fabry disease that initiate dialysis in the United States, although data from Europe suggests these individuals have a poor survival. METHODS.: Using the United States Renal Disease System database, we first studied in detail 42 Fabry patients who initiated dialysis between April 1995 (following the introduction of the new detailed HCFA 2728 form) and July 1998. To examine crude survival in a larger cohort, 95 Fabry patients were studied who initiated dialysis between 1985 and 1993, similar to the European Registry. Diabetic and non-diabetic controls matched by age, gender, race, year of dialysis initiation, and initial dialysis modality were examined for comparison. RESULTS.: During the years 1995 to 1998, the mean age of Fabry patients that initiated dialysis was 42 years, 83% were Caucasian, and 10% were African American. Despite the X-linked inheritance of Fabry disease, 12% of Fabry patients on dialysis were female. At initiation of dialysis mean serum albumin and creatinine were significantly higher and mean body mass index was significantly lower among Fabry patients, but mean glomerular filtration rate was similar to controls. Fabry patients tended to have a lower three-year survival compared to non-diabetic controls, but the results were not significantly different. In a larger cohort of Fabry patients who initiated dialysis between 1985 and 1993, the three-year survival of Fabry patients was significantly lower than non-diabetic controls: 63% (95% CI, 50 to 75%) versus 74% (95% CI, 67 to 80%; P=0.03). CONCLUSION.: End-stage renal disease is associated with significant morbidity and mortality among patients with Fabry disease. Recent evidence that progression of Fabry disease may be attenuated by enzyme replacement therapy necessitates increased awareness of Fabry disease and its comorbidities. 相似文献
89.
Nail plate and nail unit abnormalities may be helpful as diagnostic tools or as a part of the puzzle for confirmation of systemic disease. There are specific and nonspecific nail signs, which can be seen involving one or more nails, that occur simultaneously or secondary to systemic disease. Occasionally these clues can be diagnostic, while most are nonspecific reaction patterns. Nail changes occur in the nail plate as a result of nail matrix abnormalities caused by systemic disease and other systemic insults such as reactions to medications. In this article we review some of the more common nail signs that can be used to help diagnose systemic disease. 相似文献
90.