非生殖器部位特殊形态硬化性萎缩性苔藓1例

报道1例非生殖器部位特殊形态硬化性萎缩性苔藓，并经病理检查确诊。患者男，36岁。躯干、四肢群集分布白色皮疹1年余。皮疹瓷白色，扁平圆形或蝶形，可见小的粉刺样毛囊性角质栓，四周绕以红晕。予0．05％丙酸氯倍他索软膏和0．1％维胺酯霜外用，初显疗效。     

Comparison of allergen responses based on the TRUE Test and IQ Chamber system in Korean patients

Background

A comparison between responses to allergens based on the TRUE Test® (TT) and IQ® Chamber (IQC) in Europeans has been previously reported, however, no such study has been performed in Asians.

Objectives

To compare allergen responses using the TT and IQC (using the Korean standard series) in order to gather more information regarding the positive response rates for each allergen and the clinical value of IQC.

Materials & methods

Suspected contact dermatitis patients were enrolled and tested with 18 allergens using the TT and IQC.

Results

The test was performed in 214 patients. Simultaneous positive results for both tests were recorded in 242 cases (positive concordance rate: 66.7%). IQC yielded more positive results. Allergens with a high positive concordance rate were nickel sulphate (82.1%), thimerosal (78.6%), and p-phenylenediamine (73.3%). IQC mostly showed similar or higher positive rates than TT, with high concordance.

Conclusions

We recommend the IQC method as a screening test in patients with suspected contact dermatitis. To compensate for possible false positive results, careful history taking and a different patch test should be performed when appropriate.

     

The potential of non-myeloablative heterochronous autologous hematopoietic stem cell transplantation for extending a healthy life span

Aging is a complex multifactorial process, a prominent component being the senescence of the immune system. Consequently, immune-related diseases develop, including atherosclerosis, cancer, and life-threatening infections, which impact on health and longevity. Rejuvenating the aged immune system could mitigate these diseases, thereby contributing to longevity and health. Currently, an appealing option for rejuvenating the immune system is heterochronous autologous hematopoietic stem cell transplantation (haHSCT), where healthy autologous bone marrow/peripheral blood stem cells are collected during the youth of an individual, cryopreserved, and re-infused when he or she has reached an older age. After infusion, young hematopoietic stem cells can reconstitute the compromised immune system and improve immune function. Several studies using animal models have achieved substantial extension of the life span of animals treated with haHSCT. Therefore, haHSCT could be regarded as a potential procedure for preventing age-related immune defects and extending healthy longevity. In this review, the pros, cons, and future feasibility of this approach are discussed.     

A temporal/nasal asymmetry for blindsight in a localisation task: evidence for extrageniculate mediation

Some patients with hemianopia due to striate cortex lesions show above chance ability in reporting visual stimuli presented in the blind visual field, a phenomenon commonly known as blindsight. Here we report a patient with a dense right hemianopia whose blindsight shows a temporal/nasal asymmetry. MP was tested in a two-alternative forced-choice localisation task, with either the right eye or the left eye patched in separate blocks. When targets appeared in the contralesional temporal hemifield, MP's localisation performance was extremely accurate, whilst she performed at chance with targets in the contralesional nasal hemifield. This is the first demonstration of a temporal/nasal asymmetry for blindsight in a forced-choice paradigm, and is consistent with blindsight in MP's hemianopic field being mediated by a subcortical, extrageniculate route.     

AMP-18,一种新发现的胃黏膜保护因子

AMP-18是一种新发现的由胃腺体上皮细胞合成的小分子蛋白质,独特表达于胃黏膜,机体其他部位少见,胃癌组织中表达缺失．AMP-18 由185个氨基酸组成,除去N端信号肽(20个氨基酸)后大小约18 ku,第54-150个氨基酸组成高度保守的结构域(BRICHOS区域)承担主要的生理功能．AMP-18由胃腺体上皮细胞以胞吐的方式分泌到胃黏液中,他的合成和分泌与个体生长发育有关,并受福斯高林、吲哚美辛、地塞米松等药物的影响．目前发现 AMP-18的生理功能主要有促进胃黏膜上皮细胞的有丝分裂,促进细胞的迁徙,促胃肠黏膜损伤的修复,保持胃肠黏膜的完整等．