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排序方式: 共有9333条查询结果,搜索用时 15 毫秒
991.
992.
HA Pearson ; VL Richards ; BR Wylie ; D Bruce ; JM Watt ; D Wilkie ; H Kronenberg 《Transfusion》1991,31(3):257-259
A 19-year-old, untransfused Melanesian man from Papua New Guinea was admitted to the hospital for repair of an atrial septal defect. His serum contained an alloantibody that reacted strongly on the indirect antiglobulin test and was identified as anti-Ge. Gerbich-negative blood was transfused following urgent surgery. A 51Cr red cell survival study performed 2 weeks after surgery yielded zero survival of Gerbich-positive cells after 24 hours. A monocyte-driven, antibody-dependent, cell-mediated cytotoxicity assay performed on both pretransfusion and posttransfusion serum samples and on concentrated serum showed less than 1 percent specific lysis of Gerbich-positive cells. This did not correlate with the indication of clinical significance predicted by the 51Cr study. Red cell adherence and phagocytosis, not evident in a monocyte monolayer assay using native serum, were demonstrable in 16 percent of monocytes by the use of concentrated serum. 相似文献
993.
Davy Vancampfort Brendon Stubbs Justin Richards Philip B. Ward Joseph Firth Felipe B. Schuch 《Disability and rehabilitation》2017,39(24):2461-2467
Purpose: People with posttraumatic stress disorder (PTSD) have an increased risk of cardiovascular diseases (CVD). Physical fitness is a key modifiable risk factor for CVD and associated mortality. We reviewed the evidence-base regarding physical fitness in people with PTSD.Methods: Two independent reviewers searched PubMed, CINAHL, PsycARTICLES, PEDro, and SPORTDiscus from inception until May 2016 using the key words “fitness” OR “exercise” AND “posttraumatic stress disorder” OR “PTSD”.Results: In total, 5 studies involving 192 (44 female) individuals with PTSD met the inclusion criteria. Lower baseline physical fitness are associated with greater reductions in avoidance and hyperarousal symptoms, as well as with total, physical, and social symptoms of anxiety sensitivity. Rigorous data comparing physical fitness with age- and gender matched general population controls are currently lacking.Conclusions: The research field regarding physical fitness in people with PTSD is still in its infancy. Given the established relationships between physical fitness, morbidity and mortality in the general population and the current gaps in the PTSD literature, targets for future research include exploring: (a) whether people with PTSD are at risk of low physical fitness and therefore in need of intensified assessment, treatment and follow-up, (b) the relationships among physical fitness, overall health status, chronic disease risk reduction, disability, and mortality in individuals PTSD, (c) psychometric properties of submaximal physical fitness tests in PTSD, (d) physical fitness changes following physical activity in PTSD, and (e) optimal methods of integrating physical activity programs within current treatment models for PTSD.
- Implications for Rehabilitation
People with PTSD should aim to achieve 150?minutes of moderate or 75?minutes vigorous physical activity per week while also engaging in resistance training exercises at least twice a week.
Health care professionals should assist people with PTSD to overcome barriers to physical activity such as physical pain, loss of energy, lack of interest and motivation, generalized fatigue and feelings of hyperarousal.
994.
D Halliday M Madigan R A Chalmers P Purkiss S Ell J Bergstr?m P Fürst M Neuhauser P Richards 《The Quarterly journal of medicine》1981,50(197):53-62
13C-labelled alpha-keto acid analogues of valine and phenylalanine were given by mouth and by intravenous route to three healthy and four uraemic individuals who were used as their own controls. The excretion of 13CO2 in expired air and of 13C-labelled keto acid in urine was measured together with plasma and, in some cases, intramuscular concentrations of total and 13C-labelled free valine and phenylalanine. A minimum and maximum limit of degree of conversion of these two alpha-keto acids to essential amino acids were calculated and was of the order of 25-50 per cent for both keto acids given by either route in health and uraemia. 相似文献
995.
The clinical spectrum of postpartum thyroid disease 总被引:1,自引:0,他引:1
Lazarus JH; Hall R; Othman S; Parkes AB; Richards CJ; McCulloch B; Harris B 《QJM : monthly journal of the Association of Physicians》1996,89(6):429-435
The clinical and biochemical features of postpartum thyroid disease were
analysed in 152 antithyroid peroxidase antibody-positive (anti TPO+ve)
women and compared with 239 anti-TPO-ve age-matched control postpartum
women. All were assessed monthly for up to 12 months postpartum. Seventy
three anti-TPO+ve women developed post-partum thyroiditis (PPT): 19.2%
hyperthyroid alone, 49.3% hypothyroid alone, and 31.5% characterized by
hyper- followed by hypothyroidism. None of the antibody-negative women
developed any thyroid dysfunction. A significant increase in many of eleven
symptoms of hypothyroidism and some of eight symptoms of hyperthyroidism
compared to control women was observed in all anti-TPO+ve women,
independent of thyroid status. This was particularly seen in women who
later developed PPT when they were euthyroid, but was also observed in
euthyroid anti-TPO+ve women who showed no decline of thyroid function
during the postpartum period. Although PPT is usually transient, this
condition, and the euthyroid antibody-positive state, may be associated
with significant symptomatology, including an increased incidence of minor
to moderate depression. Early recognition of this syndrome by antenatal
screening of thyroid antibodies may contribute to improved management of
women during the postpartum period.
相似文献
996.
997.
Yiannoutsos CT Ernst T Chang L Lee PL Richards T Marra CM Meyerhoff DJ Jarvik JG Kolson D Schifitto G Ellis RJ Swindells S Simpson DM Miller EN Gonzalez RG Navia BA 《NeuroImage》2004,23(3):928-935
The relationship of the cellular changes in the HIV-infected brain to the onset and progression of AIDS dementia complex (ADC) remains uncertain. We undertook an in vivo proton magnetic resonance spectroscopy (MRS) study and used factor analysis to identify specific cellular and regional brain changes that may serve as metabolic markers of ADC. The ratio of N-acetyl aspartate (NAA), choline (Cho), and myoinositol (MI) over creatine (Cr), markers of neuronal and glial cell metabolism, were measured in the basal ganglia, centrum semiovale, and parietal cortex from 100 subjects with and without ADC. Three metabolic patterns were identified, which we termed "inflammatory" (mainly MI/Cr elevations in all three regions plus Cho/Cr increases in the centrum semiovale and parietal cortex), "basal ganglia" (mostly NAA/Cr and Cho/Cr elevations in the basal ganglia), and "neuronal" (primarily NAA/Cr reductions in the centrum semiovale and the parietal cortex). Logistic regression analysis revealed that, adjusted for age, basal ganglia and neuronal pattern scores were strongly associated with ADC but inflammatory levels were not. We conclude that by using factor analysis, we are able to combine multiple metabolites across brain regions in a biologically plausible manner and construct a predictive model of ADC adjusting for relevant factors such as age. 相似文献
998.
999.
J E Richards T C Gilliam J L Cole M L Drumm J J Wasmuth J F Gusella F S Collins 《Proceedings of the National Academy of Sciences of the United States of America》1988,85(17):6437-6441
The gene for Huntington disease (HD) has been localized to the distal portion of the short arm of human chromosome 4 by linkage analysis. Currently, the two closest DNA markers are D4S10 (G8), located approximately equal to 3 centimorgans centromeric to HD, and D4S43 (C4H), positioned 0-1.5 centimorgans from HD. In an effort to move closer to the HD gene, with the eventual goal of identifying the gene itself, we have applied the technique of chromosome jumping to this region. A 200-kilobase jumping library has been constructed, and a jump from D4S10 has been obtained and its approximate distance verified by pulsed field gel electrophoresis. Two restriction fragment length polymorphisms have been identified at the jump locus, which is denoted D4S81. Linkage analysis of previously identified recombinants between D4S10 and HD or D4S10 and D4S43 shows that in two of five events the jump has crossed the recombination points. This unequivocally orients D4S10 and D4S81 on the chromosome, provides additional markers for HD, and suggests that recombination frequency in this region of chromosome 4 may be increased, so that the physical distance from D4S10 to HD may not be as large as originally suspected. 相似文献
1000.
Kent L. Richards Scott R. Cannon Michael H. Crawford Sherman G. Sorensen 《The American journal of cardiology》1983,51(7):1122-1127
To differentiate normal from abnormal left-sided heart valves, 34 adults (6 normal and 28 abnormal) with 48 valve lesions proved at catheterization were examined using a 3 MHz duplex pulsed Doppler echocardiograph with 2-dimensional verification of sample volume position and on-line display of the Doppler audio spectrum. A uniform protocol was used to position the sample volume for each lesion and to analyze the Doppler spectral data. Intracardiac blood turbulence, manifested by an increased Doppler spectral envelope area, was the noninvasive indicator of disease. The specific lesion present was determined by documenting the intracardiac location and timing of the turbulence. Doppler spectral envelope areas in all normal valve sites were smaller than those measured at the same sites in patients with aortic stenosis, mitral stenosis, and mitral regurgitation (p < 0.01). Except for a single patient with minimal aortic regurgitation, spectral envelope area allowed complete separation of patients with valve disease from normal subjects (p < 0.01). High sensitivity (97%) and specificity (100%) were noted despite the presence of multiple valve lesions in 67% of the patients. The data demonstrate application of a simple, noninvasive method of acquiring and analyzing Doppler echocardiographic data which allows accurate identification or exclusion of left-sided valve disease in adults, even in the presence of multiple valve lesions. 相似文献