全文获取类型
收费全文 | 3262篇 |
免费 | 207篇 |
国内免费 | 22篇 |
专业分类
耳鼻咽喉 | 33篇 |
儿科学 | 101篇 |
妇产科学 | 60篇 |
基础医学 | 492篇 |
口腔科学 | 33篇 |
临床医学 | 347篇 |
内科学 | 686篇 |
皮肤病学 | 23篇 |
神经病学 | 242篇 |
特种医学 | 177篇 |
外科学 | 606篇 |
综合类 | 26篇 |
现状与发展 | 1篇 |
预防医学 | 210篇 |
眼科学 | 46篇 |
药学 | 187篇 |
中国医学 | 3篇 |
肿瘤学 | 218篇 |
出版年
2023年 | 17篇 |
2022年 | 30篇 |
2021年 | 67篇 |
2020年 | 41篇 |
2019年 | 67篇 |
2018年 | 78篇 |
2017年 | 63篇 |
2016年 | 68篇 |
2015年 | 98篇 |
2014年 | 123篇 |
2013年 | 166篇 |
2012年 | 265篇 |
2011年 | 255篇 |
2010年 | 148篇 |
2009年 | 141篇 |
2008年 | 236篇 |
2007年 | 231篇 |
2006年 | 195篇 |
2005年 | 215篇 |
2004年 | 187篇 |
2003年 | 167篇 |
2002年 | 184篇 |
2001年 | 25篇 |
2000年 | 17篇 |
1999年 | 18篇 |
1998年 | 33篇 |
1997年 | 16篇 |
1996年 | 10篇 |
1995年 | 21篇 |
1994年 | 21篇 |
1993年 | 16篇 |
1992年 | 22篇 |
1991年 | 12篇 |
1990年 | 11篇 |
1989年 | 11篇 |
1988年 | 12篇 |
1987年 | 15篇 |
1986年 | 12篇 |
1985年 | 12篇 |
1984年 | 13篇 |
1983年 | 10篇 |
1982年 | 17篇 |
1981年 | 11篇 |
1980年 | 15篇 |
1979年 | 13篇 |
1978年 | 9篇 |
1977年 | 6篇 |
1976年 | 6篇 |
1975年 | 7篇 |
1974年 | 6篇 |
排序方式: 共有3491条查询结果,搜索用时 12 毫秒
51.
Susan Mikkelsen Khoa Manh Dinh Jens Kjrgaard Boldsen Ole Birger Pedersen Gitte Juel Holst Mikkel Steen Petersen Kathrine Agergrd Kaspersen Bjarne Kuno Mller Kaspar Rene Nielsen Helene Martina Paarup Klaus Rostgaard Henrik Hjalgrim Erik Srensen Linda Jenny Handgaard Thomas Folkmann Hansen Karina Banasik Kristoffer Slvsten Burgdorf Henrik Ullum Torben Sigsgaard Christian Erikstrup 《Clinical and translational allergy》2021,11(1)
BackgroundAllergic rhinitis (AR), allergic conjunctivitis (AC), and asthma composing multiple phenotypes and improved understanding of these phenotypes and their respective risk factors are needed.ObjectivesThe objective of this study was to define the prevalence of AR, AC, and asthma and their association with allergen‐specific immunoglobulin E (sIgE) sensitization in a large cohort of blood donors and identify risk factors.MethodsFrom the nationwide population‐based Danish Blood Donor Study, 52,976 participants completed an electronic questionnaire including AR, AC, asthma, allergic predisposition, and childhood residence. Of these, 25,257 were additionally tested for sIgE to inhalation allergens (Phadiatop).ResultsThe prevalence of sIgE sensitization, AR, AC, and asthma was 30%, 19%, 15%, and 9%, respectively. The youngest birth cohorts had the highest prevalence of sIgE sensitization and symptoms of asthma, AR, and AC, and for asthma, they apparently experienced symptoms at an earlier age. The sIgE sensitization was positively associated with male sex. The sIgE seroprevalence was higher in participants with both AR and AC (ARC) than in participants with either AR or AC. Allergic predisposition and sIgE sensitization increased the risk of the diseases, while farm upbringing was associated with reduced prevalence of ARC, however, only in sIgE sensitized participants.ConclusionBirth year, childhood residence, sIgE sensitization, and allergic predisposition were associated with asthma, AR, and AC prevalence. Individuals with self‐reported ARC represent a primarily sIgE‐positive phenotype, while those with either AR or AC represent more diverse phenotypes. 相似文献
52.
53.
54.
55.
56.
Roguin A Zviman MM Meininger GR Rodrigues ER Dickfeld TM Bluemke DA Lardo A Berger RD Calkins H Halperin HR 《Circulation》2004,110(5):475-482
57.
Katherine A VandenHeuvel Rami N Al-Rohil Michael E Stevenson Jiang Qian Naina L Gross Rene McNall-Knapp Shibo Li Eric P Wartchow Gary W Mierau Kar-Ming Fung 《International journal of clinical and experimental pathology》2015,8(1):260-274
Pediatric primary “small round blue cell” tumors in the CNS represent several entities, some more common than others. Ewing sarcoma/peripheral primitive neuroectodermal tumor (ES/pPNET) is rare and must be distinguished from other tumors such as medulloblastoma [1, 2], atypical rhabdoid/teratoid tumor, ependymomal tumors, metastatic sarcomas, hematologic malignancies, and other mimics. Although therapy for ES/pPNET is effective, it brings severe side effects, including cardiac toxicity, making correct recognition important [3]. As small blue cell tumors look similar, diagnosis often depends on special stains, immunohistochemistry, and molecular techniques. While the combination of membranous immunohistochemical reactivity for CD99 with cytoplasmic glycogen provides effective screening, demonstration of characteristic translocations of EWSR1 (chromosome 22) or FUS (chromosome 16) by fluorescent in situ hybridization (FISH) can confirm the diagnosis. We are reporting three primary ES/pPNET of the CNS, two of which occurred in children. While the adult case demonstrates the classic histopathology, the two pediatric cases have histopathology that significantly deviates from the usual. One is suggestive of a primary sarcoma, and the other mimics an ependymoma, but all three cases are confirmed with FISH. These observations suggest that primary ES in the CNS may have histology different from the classic morphology and a high index of suspicion should be maintained in order to make the correct diagnosis. A search of the literature suggests that these tumors are most frequently seen in children and young adults. Imaging often shows a supratentorial enhancing mass that touches the leptomeninges. Survival over three years is good but long term prognosis is unknown [3, 4]. 相似文献
58.
Alice W. Tsai Colleen F. McNeil Joshua R. Leeman Hamilton B. Bennett Kwame Nti-Addae Cassey Huang Ursula A. Germann Randal A. Byrn Francoise Berlioz-Seux Rene Rijnbrand Michael P. Clark Paul S. Charifson Steven M. Jones 《Antimicrobial agents and chemotherapy》2015,59(10):6007-6016
Through antigenic drift and shifts, influenza virus infections continue to be an annual cause of morbidity in healthy populations and of death among elderly and at-risk patients. The emergence of highly pathogenic avian influenza viruses such as H5N1 and H7N9 and the rapid spread of the swine-origin H1N1 influenza virus in 2009 demonstrate the continued need for effective therapeutic agents for influenza. While several neuraminidase inhibitors have been developed for the treatment of influenza virus infections, these have shown a limited window for treatment initiation, and resistant variants have been noted in the population. In addition, an older class of antiviral drugs for influenza, the adamantanes, are no longer recommended for treatment due to widespread resistance. There remains a need for new influenza therapeutic agents with improved efficacy as well as an expanded window for the initiation of treatment. Azaindole compounds targeting the influenza A virus PB2 protein and demonstrating excellent in vitro and in vivo properties have been identified. To evaluate the in vivo efficacy of these PB2 inhibitors, we utilized a mouse influenza A virus infection model. In addition to traditional endpoints, i.e., death, morbidity, and body weight loss, we measured lung function using whole-body plethysmography, and we used these data to develop a composite efficacy score that takes compound exposure into account. This model allowed the rapid identification and ranking of molecules relative to each other and to oseltamivir. The ability to identify compounds with enhanced preclinical properties provides an opportunity to develop more-effective treatments for influenza in patients. 相似文献
59.
Linda Pilgaard Joachim Høg Mortensen Michael Henriksen Pia Olesen Preben Sørensen Rene Laursen Mogens Vyberg Ralf Agger Vladimir Zachar Torben Moos Meg Duroux 《Brain pathology (Zurich, Switzerland)》2014,24(4):360-370
Human glioblastoma multiforme (GBM) is an aggressive cancer with a very poor prognosis. Cripto‐1 (CR‐1) has a key regulatory role in embryogenesis, while in adult tissue re‐expression of CR‐1 has been correlated to malignant progression in solid cancers of non‐neuronal origin. As CR‐1 expression has yet to be described in cerebral cancer and CR‐1 is regulated by signaling pathways dysregulated in GBM, we aimed to investigate CR‐1 in the context of expression in GBM. The study was performed using enzyme‐linked immunosorbent assay (ELISA), Western blotting, polymerase chain reaction (PCR) and immunohistochemistry to analyze the blood and tissue from 28 GBM and 4 low‐grade glioma patients. Within the patient cohort, we found high CR‐1 protein levels in blood plasma to significantly correlate with a shorter overall survival. We identified CR‐1 in different areas of GBM tissue, including perivascular tumor cells, and in endothelial cells. Collectively, our data suggest that CR‐1 could be a prognostic biomarker for GBM with the potential of being a therapeutic target. 相似文献