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排序方式: 共有113条查询结果,搜索用时 15 毫秒
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目的通过整合不同的患者导向的测量工具的项目来编制ICF特定类目的等距量表结构。方法使用有效的122例类风湿关节炎患者的样本资料进行心理测量研究。患者完成6个不同的以患者导向的测量工具。将这些测量工具项目的内容与ICF类目进行匹配。对项目反应等级进行Rasch分析用于检查这些测量工具项目是否说明了ICF类目b130:能量和驱力功能,从而构成一个心理测量可靠的等距量表。结果 19个项目与b130能量和驱力功能有关。根据2χ检验和Z值统计,19个项目中的16个项目拟合Rasch模型(项目和个人的ZMean=0.451,ZSD=1.085和ZMean=-0.223,ZSD=1.132)。Person分离指数rβ是0.93。结论可以构建ICF类目等距量表使得单个ICF类目可操作化。每个项目的原始格式在等距量表中保持不变。本研究在ICF的操作和将来的实施方面迈出了重要的一步。 相似文献
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回春液补肾助阳药效学的实验研究 总被引:2,自引:0,他引:2
回春液由人参、鹿茸、貂鞭等名贵中药组成。有补肾助阳,填精益气等功效。药效学研究证实,该药有促进幼鼠发育及增加去势大鼠前列腺——精液囊的重量,亦显著增加小鼠血红蛋白的含量,表明回春液有雄性激素样作用。 相似文献
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Meniru GI; Gorgy A; Podsiadly BT; Craft IL 《Human reproduction (Oxford, England)》1997,12(11):2443-2446
Percutaneous epididymal sperm aspiration (PESA) and intracytoplasmic sperm
injection (ICSI) were carried out in patients with congenital bilateral
absence of the vas deferens (CBAVD) and men with failed reversal of
vasectomy (FRV). PESA was successful in 55 out of 62 patients with CBAVD
(89%) and in 57 out of 60 men with FRV (95%). The fertilization rates after
ICSI (53 and 55%), cleavage rates (70 and 76%) and pregnancy rates (36 and
32%) did not differ significantly between the two respective groups (CBAVD
and FRV). PESA and ICSI are effective both in patients with CBAVD and in
those with FRV.
相似文献
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RD Maw † GR Kinghorn ‡ CA Bowman § BT Goh ¶ AT Nayagam M Nathan†† 《Journal of the European Academy of Dermatology and Venereology》2002,16(1):58-62
OBJECTIVES: To determine the safety and efficacy of imiquimod (Aldara) 5% cream in the treatment of prepuce-associated warts in uncircumcised males. METHODS: An open-label study in six UK medical centres with 35 uncircumcised males with prepuce-associated warts treated with imiquimod 5% cream three times per week for up to 16 weeks. Other anogenital warts were also treated. RESULTS: Three times weekly application of imiquimod was found to be safe, with erythema as the most commonly reported local skin reaction. Forty per cent of patients had complete clearance of anogenital warts within 16 weeks. CONCLUSIONS: Imiquimod cream at a dosing regimen of three times per week, is effective and has an acceptable safety profile in the treatment of prepuce associated warts and other external anogenital warts in uncircumcised males. 相似文献
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Genetic association of an alpha2-macroglobulin (Val1000lle) polymorphism and Alzheimer's disease 总被引:6,自引:1,他引:5
Liao A; Nitsch RM; Greenberg SM; Finckh U; Blacker D; Albert M; Rebeck GW; Gomez-Isla T; Clatworthy A; Binetti G; Hock C; Mueller-Thomsen T; Mann U; Zuchowski K; Beisiegel U; Staehelin H; Growdon JH; Tanzi RE; Hyman BT 《Human molecular genetics》1998,7(12):1953-1956
alpha2-Macroglobulin (A2M) is a proteinase inhibitor found in association
with senile plaques (SP) in Alzheimer's disease (AD). A2M has been
implicated biochemically in binding and degradation of the amyloid beta
(Abeta) protein which accumulates in SP. We studied the relationship
between Alzheimer's disease and a common A2M polymorphism, Val1000
(GTC)/Ile1000 (ATC), which occurs near the thiolester active site of the
molecule. In an initial exploratory data set (90 controls and 171
Alzheimer's disease) we noted an increased frequency of the G/G genotype
from 0.07 to 0.12. We therefore tested the hypothesis that the G/G genotype
is over-represented in Alzheimer's disease in an additional independent
data set: a group of 359 controls and 566 Alzheimer's disease patients. In
the hypothesis testing cohort, the G/G genotype increased from 0.07 in
controls to 0.12 in Alzheimer's disease (P < 0.05, Fisher's exact test).
The odds ratio for Alzheimer's disease associated with the G/G genotype was
1.77 (1.16-2.70, P < 0.01) and in combination with APOE4 was 9.68 (95%
CI 3.91-24.0, P < 0.001). The presence of the G allele was associated
with an increase in Abeta burden in a small series. The A2M receptor,
A2M-r/LRP, is a multifunctional receptor whose ligands include
apolipoprotein E and the amyloid precursor protein. These four proteins
have each been genetically linked to Alzheimer's disease, suggesting that
they may participate in a common disease pathway.
相似文献
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