全文获取类型
收费全文 | 190篇 |
免费 | 18篇 |
专业分类
耳鼻咽喉 | 1篇 |
儿科学 | 17篇 |
妇产科学 | 1篇 |
基础医学 | 24篇 |
口腔科学 | 3篇 |
临床医学 | 13篇 |
内科学 | 51篇 |
皮肤病学 | 3篇 |
神经病学 | 3篇 |
特种医学 | 4篇 |
外科学 | 11篇 |
综合类 | 8篇 |
预防医学 | 18篇 |
眼科学 | 13篇 |
药学 | 24篇 |
肿瘤学 | 14篇 |
出版年
2023年 | 1篇 |
2021年 | 4篇 |
2020年 | 9篇 |
2019年 | 6篇 |
2018年 | 12篇 |
2017年 | 6篇 |
2016年 | 8篇 |
2015年 | 5篇 |
2014年 | 7篇 |
2013年 | 10篇 |
2012年 | 25篇 |
2011年 | 16篇 |
2010年 | 6篇 |
2009年 | 5篇 |
2008年 | 8篇 |
2007年 | 14篇 |
2006年 | 19篇 |
2005年 | 7篇 |
2004年 | 8篇 |
2003年 | 8篇 |
2002年 | 9篇 |
2001年 | 3篇 |
2000年 | 4篇 |
1998年 | 3篇 |
1995年 | 1篇 |
1994年 | 1篇 |
1984年 | 1篇 |
1977年 | 1篇 |
1974年 | 1篇 |
排序方式: 共有208条查询结果,搜索用时 0 毫秒
41.
42.
M. Revathi B. Kavitha N. Senthil Kumar 《journal of environmental science and health part c-environmental carcinogenesis & ecotoxicology reviews》2019,37(1):42-54
Reactive Red 195 was detected from industrial waste samples electrochemically on graphene modified glassy carbon electrode (GCE), using both bare and surface changed GCE at different pH media from 1.0 to 13.0. The optimum pH was determined to be 4.0. RR 195 exhibited good linear responds at pH 4.0 on both electrode surfaces. Other parameters, such as accumulation potential, accumulation time, initial scan potential, pulse height, pulse width, and potential scan increment and scan rate are optimized and calibration plot was also derived on different concentrations of the dye. The stripping voltammetric behavior of dye exhibits very low limit of detection on graphene coated electrode (30?ppb). The adsorption of compound on GCE and graphene coated GCE are confirmed using atomic force microscopy studies. 相似文献
43.
Geoerger B Kieran MW Grupp S Perek D Clancy J Krygowski M Ananthakrishnan R Boni JP Berkenblit A Spunt SL 《European journal of cancer (Oxford, England : 1990)》2012,48(2):253-262
PurposeA phase II study of temsirolimus was conducted in children and adolescents with high-grade glioma, neuroblastoma or rhabdomyosarcoma.Patients and methodsTemsirolimus 75 mg/m2 was administered once weekly until disease progression or intolerance. Using the Simon 2-stage design, further enrolment in each disease cohort required ⩾2 objective responses within the first 12 weeks for the first 12 evaluable patients (those who received ⩾3 temsirolimus doses).ResultsFifty-two heavily pretreated patients with relapsed (12%) or refractory (88%) disease, median age 8 years (range 1–21 years), were enroled and treated. One patient with neuroblastoma achieved confirmed partial response within the first 12 weeks; thus, none of the 3 cohorts met the criterion for continued enrolment. Disease stabilisation at week 12 was observed in 7 of 17 patients (41%) with high-grade glioma (5 diffuse pontine gliomas, 1 glioblastoma multiforme and 1 anaplastic astrocytoma), 6 of 19 (32%) with neuroblastoma and 1 of 16 (6%) with rhabdomyosarcoma (partial response confirmed at week 18). In the three cohorts, median duration of stable disease or better was 128, 663 and 75 d, respectively. The most common treatment-related adverse events were thrombocytopaenia, hyperlipidaemia and aesthenia. Pharmacokinetic findings were similar to those observed in adults.ConclusionsTemsirolimus administered weekly at the dose of 75 mg/m2 did not meet the primary objective efficacy threshold in children with high-grade glioma, neuroblastoma or rhabdomyosarcoma; however, meaningful prolonged stable disease merits further evaluation in combination therapy. 相似文献
44.
Rosamma Joseph MG Jose Raj Shobha Sundareswaran Priyanka Chand Kaushik Amol Vijay Nagrale Susan Jose Sreeraj Rajappan 《World Journal of Rheumatology》2014,4(3):80-87
Periodontitis or Periodontal disease(PD) and Rheumatoid arthritis(RA) are two the most common chronic inflammatory diseases. Periodontitis is a biofilm associated destructive inflammatory disease of the periodontium caused by specific microorganisms. Rheumatoid arthritis is an autoimmune condition and is identified by elevated serum autoantibody titre directed against citrullinated peptides or rheumatoid factor. Periodontitis may involve some elements of autoimmunity. Recent studies have established that PD and RA show a common pathway and could be closely associated through a common dysregulation and dysfunction in inflammatory mechanism. The enzyme peptidyl arginine deiminase(PAD), expressed by Porphyromonas gingivalis(P. gingivalis) is responsible for the enzymatic deimination of arginine residuals to citrulline resulting in protein citrullination and its increased accumulation in RA.Citrullination by PAD may act as a putative biologic link between PD and RA. Association of Human leukocytic antigen-DR4 antigen has been established both with RA and PD. Several interleukins and inflammatory mediators(ILs) and Nuclear factor kappa beta ligand are linked to these common chronic inflammatory diseases. Antibodies directed against heat shock protein(hsp 70 ab) of P. gingivalis, P. melanogenicus and P. intermedia are raised in PD as well as RA. Both the conditions share many pathological and immunological similarities. Bacterial infection, genetic susceptibility, altered immune reaction and inflammatory mediators considered responsible for RA are also associated with PD. So it is plausible that a biological link may exist between PD and RA. Therapies aimed at modifying the expression and effect of inflammatory mediators and effector molecules such as matrix metalloproteinases, proinflammatory cytokines and autoantibodies of structural proteins may probably reduce the severity of both RA and PD. 相似文献
45.
We report a 7-year-old boy with very severe tetanus treatedwith continuous infusion of magnesium sulphate for the controlof spasms and severe autonomic dysfunction which was refractoryto deep sedation and mechanical ventilation. The infusion wasnot associated with any adverse effects and he made an uneventfulrecovery. We recommend the use of intravenous magnesium sulphateinfusion as an inexpensive and highly effective modality insevere tetanus. 相似文献
46.
Ashley Rajappan BSc Anna Pearce PhD Hazel M. Inskip PhD Janis Baird PhD Sarah R. Crozier PhD Cyrus Cooper FMedSci Keith M. Godfrey FRCP Graham Roberts MRCPCH DM Jane S.A. Lucas FRCPCH PhD Katharine C. Pike FRCPCH PhD The Southampton Women's Survey Study Group 《Pediatric pulmonology》2017,52(10):1291-1299
47.
G. Revathi Arun Goyal 《Indian journal of otolaryngology and head and neck surgery》1998,50(2):178-180
Diphtheritic infection of the ear is very rare. We report here a case of Primary Diphtheritic Otitis Media with a brief review of the literature. 相似文献
48.
We describe the ocular alterations and the management after stings from Hymenopteran insects. In all the five patients, the insect was identified as bee. The patients presented with significant corneal edema, which resolved dramatically in three of them after removal of stingers. Among the other two one went for permanent corneal decompensation and the other developed Intumuscent cataract with increased intraocular pressure. Although a rare occurrence, ocular trauma caused by Hymenopteran insects has a potential to cause severe ocular damage in humans. A high level of clinical suspicion and immediate removal of the stingers along with administration of high doses of topical and systemic steroids is a must to prevent chances of permanent corneal damage and intraocular complications. 相似文献
49.
Thanigaivel A Chandrasekaran R Revathi K Nisha S Sathish-Narayanan S Kirubakaran SA Senthil-Nathan S 《Parasitology research》2012,110(5):1993-1999
The larvicidal activities of methanolic fractions from Adhatoda vasica leaf extracts were investigated against the bancroftian filariasis vector Culex quinquefasciatus and dengue vector Aedes aegypti. The results indicated that the mortality rates was high at 100, 150, 200 and 250 ppm of methanol extract of fractions III
with R
f value 0.67 and methanol extract of fraction V with R
f value 0.64 of A. vasica against all the larval instars of C. quinquefasciatus and A. aegypti. The result of log probit analysis (at 95% confidence level) revealed that lethal concentration, LC50 and LC90 values were 106.13 and 180.6 ppm for fraction III, 110.6 and 170 ppm for fraction V of C. quinquefasciatus. And, the LC50 and LC90 values were 157.5 and 215.5 ppm for fraction III of A. aegypti and 120 and 243.5 ppm for the fraction V of A. aegypti, respectively. All the tested fractions proved to have strong larvicidal activity (doses from 100 to 250 ppm) against C. quinquefasciatus and A. aegypti. In general, second instar was more susceptible than the later instar. The results achieved suggest that, in addition to
their ethnopharmacology value, A. vasica may also serve as a natural larvicidal agent. 相似文献
50.
Melina G Rajappan K Amrani M Khaghani A Pennell DJ Yacoub MH 《The Journal of heart valve disease》2002,11(1):67-74; discussion 74
BACKGROUND AND AIM OF THE STUDY: The changes in geometry of the aortic root during the cardiac cycle are thought to be essential for optimal valve function, both in terms of leaflet stress and dynamic behavior. Using cardiac magnetic resonance (CMR), the study aim was to determine aortic root distensibility of the homograft (group H) and the Medtronic Freestyle xenograft (group F) after aortic root replacement, from a prospective randomized trial. METHODS: CMR was performed in 15 patients (six homografts, nine Freestyle) at six months and one year after surgery. Percentage change in aortic radius (PCR) and pressure strain elastic modulus (PSEM) were measured as indices of distensibility, and results related to left ventricular mass (LVM). RESULTS: At six months after surgery, mean PCR was 12+/-2.5 in group H and 12.9+/-6.1 in group F (p = NS), and PSEM was 428.5+/-69.8 and 493.5+/-72.7 g/cm2, respectively (p = NS). PCR was reduced to 10+/-1.7% in group H, and by 8.5+/-2.8% in group F (p = NS), while PSEM was increased to 520.5+/-87.3 and 825+/-420.4, respectively (p = NS) at the one-year follow up. Regression analysis showed a correlation between PCR and LVM (r = 0.52, p = 0.08) and LVM index (r = 0.46, p = 0.14), respectively. In addition, there was a relationship between PSEM, LVM and LVM index, suggesting that the stiffer the root wall, the higher the postoperative LVM. CONCLUSION: Up to one year after aortic root replacement, the wall of both the allogenic and xenogenic valves retained near-normal distensibility. For the first time, a correlation was demonstrated between the elastic properties of the aortic root and LVM. The longer-term behavior and clinical implications of these findings require further investigation. 相似文献