108.
Background: Hyperphosphatemia is common in hemodialysis patients. Recent animal studies show that nicotinamide inhibits the sodium dependent
phosphate co-transport in the small intestine and thereby reduces serum phosphorus levels. Nicotinic acid which is the prodrug
of nicotinamide is widely used as antihyperlipidemic agent. We examined in a prospective study whether it reduces serum phosphorus
levels in hemodialysis patients.
Methods: Patients who were on maintenance hemodialysis were enrolled in to the study if their predialysis serum phosphorus was more
than 6 mg/dl. During the pre-trial run in period of 1 week all phosphate binders were stopped. A single dose of extended release
nicotinic acid (375 mg) tablet was given with meal. Repeat measurements of serum calcium, phosphorus and alkaline phosphatase
were carried out after 8 weeks. Then the drug was stopped in a subgroup of patients and serum phosphorus remeasured after
2 weeks.
Results : There were 34 patients with varied etiological spectrum of end stage renal disease. They were on hemodialysis for a mean
period of 8.7 months. Serum phosphorus levels changed significantly from a pre treatment level of 7.7±1.5 mg/dl to post treatment
level of 5.6 ±1 mg/dl (
p<0.001). There was no significant variance across age groups, sex, disease categories and dialysis duration. The calcium level
increased from 8.1±1.0 to 8.5±1.0 mg/dl (
p<0.015). The serum alkaline phosphatase level decreased significantly from 107±66 IU/l to 82±46 IU/l (
p<0.001 ). There was a significant reduction of calcium phosphate product from 63.1+15.1 mg
2 to 48.7±10.9 mg
2/dl
2 (
p<0.001). Oral nicotinic acid was well tolerated. Mild pruritus was encountered in 2 patients.
Conclusion: Oral nicotinic acid may emerge as a safe, low cost yet powerful agent for phosphorus control in dialysis patients.
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