Lung cancer and prior tuberculosis infection in Shanghai

In a population-based case-control study of lung cancer in Shanghai involving interviews during 1984-86 with 1,405 cancer patients and 1,495 controls, a significant 50% elevation in the risk of lung cancer, adjusted for cigarette smoking, was observed among persons who had a history of tuberculosis. Among those diagnosed with tuberculosis within the past 20 years, the risk exceeded 2.5-fold. In males the lung cancers tended to occur on the same side as the previous tuberculosis infection. For both sexes, the effect of recent tuberculosis was most apparent for adenocarcinoma and peripheral tumours. No relationship was found between lung cancer risk and the type of tuberculosis therapy, including use of isoniazid. The findings suggest that tuberculosis may predispose to lung cancer, with the association most apparent among recent survivors of the infection.     

截瘫患者血红蛋白水平的10年回顾性分析

通过对97例截瘫住院患者连续10年的Hb测定结果进行回顾性分组研究,结果表明,无并发症组10年中Hb分布较一致,其均值与正常人比较无显著性差异(P>0.05),但12.3％的病例Hb水平低于正常人下限;当截瘫并发泌尿系感染、尿毒症或难治性褥疮等病症时,则导致Hb水平的降低。提出Hb测定结果,可做为在整体水平上观察截瘫患者的治疗及康复效果的指标。     

Sympathetic skin response and R–R interval variation in chronic uremic patients

Sympathetic skin response (SSR) and R–R interval variation (RRIV) were studied in 36 chronic, nondiabetic uremics to compare with their nerve conduction studies (NCS) and clinical dysautonomia. Abnormal SSR was noted in 5 (13.9%) patients, abnormal RRIV in 14 (38.9%), and abnormal NCS in 26 (72.2%). The patients were classified into three groups: group (GP) 1: “normal,” n = 21 (58.3%), normal RRIV and SSR; GP 2: “isolated parasympathetic dysfunction,” n = 10 (27.8%), abnormal RRIV and normal SSR; and GP 3: “sympathetic sudomotor dysfunction,” n = 5 (13.9%), abnormal SSR. A significant difference in age was found among the three groups (GP 3 > GP 2 > GP 1; P < 0.0001, ANOVA). After controlling the age factor, we still noted a tendency toward increasing NCS disturbances (distal latency and nerve conduction velocity of peroneal nerve; P < 0.05, multiple regression analysis) and frequencies of clinical autonomic symptoms (postural dizziness and impotence; P < 0.05, Mantel–Hanszel test) from GP 1 to GP 3. Patients with abnormal SSR (GP 3) displayed significantly higher frequencies of postural dizziness and impotence, indicating the relationship between an absence of SSR and clinical dysautonomia. © 1994 John Wiley & Sons, Inc.     

影响原发性肝癌介入治疗生存因素的Cox模型分析

目的：了解三种介入治疗方法对原发肝癌生存因素的影响。方法：应用Ｃｏｘ回归模型对２９８例不能切除的原发性肝癌介入治疗后的预后进行多因素分析。结果：２３项指标中筛选出对生存影响显著的６项因素。按其对生存影响的大小排列分别为：肿瘤大小、二步切除、肿瘤数目、动静脉瘘、门脉癌栓和介入次数。结论：二步切除和介入次数为保护因子，能延长生存期。其余４项为危险因子，可缩短生存期。     

枸橼酸抗凝血液透析

研究解剖高危出血患者血液透析的抗凝方法－局部枸橼酸抗凝的临床应用和疗效。方法：采用１．６ｍｏｌ／Ｌ的枸橼酸钠、空心纤维透析器和普通含钙碳酸氢盐透析，观察ＲＣＡ透析对患者出血、体外循环凝血、血游离钙、总钙、Ｋ＾＋，Ｎａ＾＋，ｐＨ，ＨＣＯ＾－３，Ｓｃｒ，ＢＵＮ及血清枸橼酸浓度的影响。     

人前列腺癌细胞PC-3M亚系u-PAR基因与蛋白质表达

为研究与人前列腺癌细胞（PC-3M）侵袭能力相关的靶分子，采用有限稀释法分离单克隆细胞株，并应用单层细胞侵袭等实验鉴定各亚系的体外侵袭能力；借助RT-PCR和免疫组化的方法，分别在转录和翻译水平检测5株侵袭能力不同的PC-3M亚系尿激酶型纤溶酶原激活物受体（u-PAR)的表达。结果显示，高侵袭亚系-u-PAR基因mRNA的表达和蛋白质水平均明显高于低侵袭亚系，提示；PC-3M亚系u-PAR的高表达与其较强的侵袭能力密切相关，而u-PAR可能是抑制高侵袭亚系侵袭效应的一个重要靶分子。     

复合红外光治疗寻常型痤疮临床观察

目的 评价复合红外光治疗寻常型痤疮的疗效及其安全性.方法 将120例门诊痤疮患者随机分为两组,实验组60例采用复合红外光美容仪照射治疗1～8周,对照组采用暗疮面膜治疗1～8周,在治疗的第1、2、4、8周进行随访,严格记录每次治疗后皮损变化及不良反应,以治疗后炎性皮损减少百分率评价疗效,并观察其安全性.结果 实验组治疗的总有效率为91.67%,对照组治疗的总有效率为83.33%,经秩和检验,P＜0.05,两者治疗有显著性差异,实验组在治疗过程中除出现一过性红斑外,未发现其他不良反应.结论 复合红外光治疗寻常型痤疮疗效显著、起效快、疗程短、无痛苦、安全性高.     

336例创伤数据对中国人创伤评分权重系数的评价

目的为了评价国内对ＴＲＩＳＳ评分权重系数的修订，对３３６例创伤患者分别用国外权重和国内权重评定伤情后进行比较。方法３３６例采用ＴＲＩＳＳ法计算生存概率Ｐｓ，所需权重分别采用新近报道的国内权重和国外ＭＴＯＳ权重。Ｐｓ≥０．５预测生存，Ｐｓ＜０．５预测死亡，将预测生死与实际生死结果进行比较。结果中国人权重在敏感性和区别度方面高于国外权重，误判率低于国外权重。结论中国人权重对中国人的创伤程度评估有价值，为进一步精确修订权重，建议建立大型中国人创伤数据库     

抗肿瘤药复方三生注射液的研究

复方三生注射液是由生附片等六味中药组成的静注用灭菌水溶液。本文综合报道了该制剂的制备方法,质量分析,抗肺癌作用的药理及临床等研究的主要内容。结果表明,本品是治疗中晚期肺癌有效的中药复方注射剂。