全文获取类型
收费全文 | 1937篇 |
免费 | 216篇 |
国内免费 | 20篇 |
专业分类
耳鼻咽喉 | 20篇 |
儿科学 | 56篇 |
妇产科学 | 31篇 |
基础医学 | 159篇 |
口腔科学 | 51篇 |
临床医学 | 272篇 |
内科学 | 401篇 |
皮肤病学 | 129篇 |
神经病学 | 71篇 |
特种医学 | 142篇 |
外科学 | 291篇 |
综合类 | 97篇 |
现状与发展 | 30篇 |
一般理论 | 1篇 |
预防医学 | 90篇 |
眼科学 | 150篇 |
药学 | 73篇 |
中国医学 | 4篇 |
肿瘤学 | 105篇 |
出版年
2024年 | 18篇 |
2023年 | 181篇 |
2022年 | 19篇 |
2021年 | 34篇 |
2020年 | 58篇 |
2019年 | 36篇 |
2018年 | 77篇 |
2017年 | 58篇 |
2016年 | 46篇 |
2015年 | 65篇 |
2014年 | 104篇 |
2013年 | 97篇 |
2012年 | 95篇 |
2011年 | 82篇 |
2010年 | 96篇 |
2009年 | 111篇 |
2008年 | 89篇 |
2007年 | 97篇 |
2006年 | 56篇 |
2005年 | 43篇 |
2004年 | 42篇 |
2003年 | 36篇 |
2002年 | 36篇 |
2001年 | 26篇 |
2000年 | 32篇 |
1999年 | 43篇 |
1998年 | 40篇 |
1997年 | 52篇 |
1996年 | 45篇 |
1995年 | 40篇 |
1994年 | 33篇 |
1993年 | 38篇 |
1992年 | 17篇 |
1991年 | 21篇 |
1990年 | 21篇 |
1989年 | 27篇 |
1988年 | 24篇 |
1987年 | 18篇 |
1986年 | 12篇 |
1985年 | 12篇 |
1984年 | 8篇 |
1982年 | 9篇 |
1981年 | 10篇 |
1980年 | 12篇 |
1978年 | 9篇 |
1977年 | 3篇 |
1976年 | 13篇 |
1975年 | 12篇 |
1974年 | 5篇 |
1959年 | 3篇 |
排序方式: 共有2173条查询结果,搜索用时 15 毫秒
101.
102.
Gregory E. Tasian Jose E. Pulido Antonio Gasparrini Christopher S. Saigal Benjamin P. Horton J. Richard Landis Rodger Madison Ron Keren for the Urologic Diseases in America Project 《Environmental health perspectives》2014,122(10):1081-1087
Background: High ambient temperatures are a risk factor for nephrolithiasis, but the precise relationship between temperature and kidney stone presentation is unknown.Objectives: Our objective was to estimate associations between mean daily temperature and kidney stone presentation according to lag time and temperatures.Methods: Using a time-series design and distributed lag nonlinear models, we estimated the relative risk (RR) of kidney stone presentation associated with mean daily temperatures, including cumulative RR for a 20-day period, and RR for individual daily lags through 20 days. Our analysis used data from the MarketScan Commercial Claims database for 60,433 patients who sought medical evaluation or treatment of kidney stones from 2005–2011 in the U.S. cities of Atlanta, Georgia; Chicago, Illinois; Dallas, Texas; Los Angeles, California; and Philadelphia, Pennsylvania.Results: Associations between mean daily temperature and kidney stone presentation were not monotonic, and there was variation in the exposure–response curve shapes and the strength of associations at different temperatures. However, in most cases RRs increased for temperatures above the reference value of 10°C. The cumulative RR for a daily mean temperature of 30°C versus 10°C was 1.38 in Atlanta (95% CI: 1.07, 1.79), 1.37 in Chicago (95% CI: 1.07, 1.76), 1.36 in Dallas (95% CI: 1.10, 1.69), 1.11 in Los Angeles (95% CI: 0.73, 1.68), and 1.47 in Philadelphia (95% CI: 1.00, 2.17). Kidney stone presentations also were positively associated with temperatures < 2°C in Atlanta, and < 10°C in Chicago and Philadelphia. In four cities, the strongest association between kidney stone presentation and a daily mean temperature of 30°C versus 10°C was estimated for lags of ≤ 3 days.Conclusions: In general, kidney stone presentations increased with higher daily mean temperatures, with the strongest associations estimated for lags of only a few days. These findings further support an adverse effect of high temperatures on nephrolithiasis.Citation: Tasian GE, Pulido JE, Gasparrini A, Saigal CS, Horton BP, Landis JR, Madison R, Keren R, for the Urologic Diseases in America Project. 2014. Daily mean temperature and clinical kidney stone presentation in five U.S. metropolitan areas: a time-series analysis. Environ Health Perspect 122:1081–1087; http://dx.doi.org/10.1289/ehp.1307703 相似文献
103.
104.
105.
106.
107.
108.
Guadalupe Muñoz-Arenas Guadalupe Pulido Samuel Treviño Rubén Vázquez-Roque Gonzalo Flores Carolina Moran Anabella Handal-Silva Jorge Guevara Berenice Venegas Alfonso Díaz 《Synapse (New York, N.Y.)》2020,74(9):e22153
Metabolic syndrome (MS) is a health problem that is characterized by body fat accumulation, hypertension, dyslipidemia, and hyperglycemia; recently, it has been demonstrated that MS also damages memory processes. The first-line drug in the treatment of MS and type 2 diabetes mellitus is metformin, which is an antihyperglycemic agent. This drug has been shown to produce neuroprotection and to improve memory processes. However, the mechanism involved in this neuroprotection is unknown. A 90-day administration of metformin improved the cognitive processes of rats with MS as evaluated by the novel object recognition test, and this finding could be explained by an increase in the neuronal spine density and spine length. We also found that metformin increased the immunoreactivity of synaptophysin, sirtuin-1, AMP-activated protein kinase, and brain-derived neuronal factor, which are important plasticity markers. We conclude that metformin is an important therapeutic agent that increases neural plasticity and protects cognitive processes. The use of this drug is important in the minimization of the damage caused by MS. 相似文献
109.
Ram n Cantero-Cid Karla Marina Montalb n-Hern ndez Jenny Guevara Alejandro Pascual-Iglesias Elisa Pulido Jos Carlos Casalvilla Crist bal Marcano Cristina Barrag n Serrano Jaime Valent n Gloria Cristina Bonel-P rez Jos Avenda o-Ortiz Ver nica Terr n Roberto Lozano-Rodr guez Alejandro Mart n-Quir s Elvira Mar n Eva Pena Laura Guerra-Pastri n Eduardo L pez-Collazo Luis Augusto Aguirre 《World journal of gastrointestinal oncology》2022,14(1):295-318
110.