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71.
Dinkler A. Harmann Müllar Oettel Rosenhagen Pauschardt Preuss Meesmann Maier 《Journal of molecular medicine (Berlin, Germany)》1939,18(37):1261-1263
Ohne Zusammenfassung 相似文献
72.
Schübel A. Hermann Müller Oettel Stefan Preuss Sperling Mader Zinn Rosenhagen Dinkler 《Journal of molecular medicine (Berlin, Germany)》1938,17(41):1450-1452
Ohne Zusammenfassung 相似文献
73.
Vaternahm Rosenhagen Dinkler Fuchs Hüsselrath Pendl Uhlmann W. Fischer Bernhardt Koch F. Fischer Lehrnbecher Sperling Preuss 《Journal of molecular medicine (Berlin, Germany)》1938,17(23):824-827
Ohne Zusammenfassung 相似文献
74.
NSF workshop report: Discovering general principles of nervous system organization by comparing brain maps across species 下载免费PDF全文
Georg F. Striedter T. Grant Belgard Chun‐Chun Chen Fred P. Davis Barbara L. Finlay Onur Güntürkün Melina E. Hale Julie A. Harris Erin E. Hecht Patrick R. Hof Hans A. Hofmann Linda Z. Holland Andrew N. Iwaniuk Erich D. Jarvis Harvey J. Karten Paul S. Katz William B. Kristan Eduardo R. Macagno Partha P. Mitra Leonid L. Moroz Todd M. Preuss Clifton W. Ragsdale Chet C. Sherwood Charles F. Stevens Maik C. Stüttgen Tadaharu Tsumoto Walter Wilczynski 《The Journal of comparative neurology》2014,522(7):1445-1453
Efforts to understand nervous system structure and function have received new impetus from the federal Brain Research through Advancing Innovative Neurotechnologies (BRAIN) Initiative. Comparative analyses can contribute to this effort by leading to the discovery of general principles of neural circuit design, information processing, and gene‐structure‐function relationships that are not apparent from studies on single species. We here propose to extend the comparative approach to nervous system ‘maps' comprising molecular, anatomical, and physiological data. This research will identify which neural features are likely to generalize across species, and which are unlikely to be broadly conserved. It will also suggest causal relationships between genes, development, adult anatomy, physiology, and, ultimately, behavior. These causal hypotheses can then be tested experimentally. Finally, insights from comparative research can inspire and guide technological development. To promote this research agenda, we recommend that teams of investigators coalesce around specific research questions and select a set of ‘reference species' to anchor their comparative analyses. These reference species should be chosen not just for practical advantages, but also with regard for their phylogenetic position, behavioral repertoire, well‐annotated genome, or other strategic reasons. We envision that the nervous systems of these reference species will be mapped in more detail than those of other species. The collected data may range from the molecular to the behavioral, depending on the research question. To integrate across levels of analysis and across species, standards for data collection, annotation, archiving, and distribution must be developed and respected. To that end, it will help to form networks or consortia of researchers and centers for science, technology, and education that focus on organized data collection, distribution, and training. These activities could be supported, at least in part, through existing mechanisms at NSF, NIH, and other agencies. It will also be important to develop new integrated software and database systems for cross‐species data analyses. Multidisciplinary efforts to develop such analytical tools should be supported financially. Finally, training opportunities should be created to stimulate multidisciplinary, integrative research into brain structure, function, and evolution. J. Comp. Neurol. 522:1445–1453, 2014. © 2014 Wiley Periodicals, Inc. 相似文献
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77.
GL Marseglia S Savasta A Ravelli TM Gaino GR Burgio 《Acta paediatrica (Oslo, Norway : 1992)》1995,84(9):1086-1088
We report the case of a 9-year-old boy with a spinal cord meningioma whose only manifestations were recurrent episodes of chest pain lasting for 2 years. This case shows that spinal cord meningioma should be considered among the possible causative factors of chronic chest pain in childhood. Chest pain, meningioma, spinal tumors 相似文献
78.
Schmitt GJ Meisenzahl EM Dresel S Tatsch K Rossmüller B Frodl T Preuss UW Hahn K Möller HJ 《Journal of psychopharmacology (Oxford, England)》2002,16(3):200-206
The aim of this investigation was to compare the degree of striatal dopamine-(D2) receptor blockade by two atypical antipsychotic drugs, risperidone and olanzapine. The percentage of D2 receptor occupancy during treatment was calculated by comparing the results of 123I-iodobenzamide SPECT with those from healthy control subjects. Twenty inpatients suffering from schizophrenia or schizoaffective psychosis according to DSM IV/ICD-10 criteria were treated with clinically recommended doses of risperidone and compared with 13 inpatients treated with up to 20 mg olanzapine. Neuroleptic dose and D2 receptor blockade correlated strongly for both risperidone (Pearson r = -0.86, p = 0.0001) and olanzapine (Pearson r = -0.77, p = 0.002). There was no significant difference between the D2 receptor occupancy of the two substances when given in the clinically recommended dose range (unpaired t-test, t = -0.112, p = 0.911). 相似文献
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Clinical evaluation of biomarkers in Gaucher disease 总被引:1,自引:0,他引:1
Novel or candidate biomarkers require thorough evaluation to establish their utility in a clinical setting. This paper describes an evaluation of several established enzyme markers of Gaucher disease and a newly-described chemokine, pulmonary and activation-regulated chemokine (PARC). The ability of the biomarkers to rank patients with Gaucher disease in order of disease severity and organ bulk, and to reflect changes in key clinical parameters in response to enzyme replacement therapy were evaluated. PARC concentrations were found to be reliably correlated with visceral disease and with key clinical responses to enzyme replacement in an unbiased manner. Unlike chitotriosidase and serum angiotensin-converting enzyme activity, genetic variation in serum PARC did not appear to influence its utility as a biomarker.
Conclusion: For each new candidate biomarker of lysosomal storage diseases, a similar clinical evaluation will be required, though the approach will need to be modified according to the clinical features and natural history of each disorder. 相似文献
Conclusion: For each new candidate biomarker of lysosomal storage diseases, a similar clinical evaluation will be required, though the approach will need to be modified according to the clinical features and natural history of each disorder. 相似文献