Recent advances in metal nanoparticles in cancer therapy

Metal nanoparticles (NPs) may have the potential to overcome problems related to conventional chemotherapy. Metal NPs reported to play a beneficial and powerful role in cancer therapy providing better targeting, gene silencing and drug delivery. Functionalised metal NPs with targeting ligands offer a better control of energy deposition in the tumours. Apart from therapeutic benefits, metal NPs are also used as a diagnostic tool for the imaging of cancer cells. Metal NP-based therapeutic systems not only provide simultaneous diagnostic and therapy but also allow controlled and targeted drug release which helps to revolutionise cancer treatment and management. This review addresses the advancement of metal NPs in tumour therapy with a focus on those being explained into clinical settings.     

Effect of Acetabular Component Positioning on Functional Outcomes in Primary Total Hip Arthroplasty

Background

Acetabular component positioning is crucial to a successful total hip arthroplasty (THA). This study evaluated the effect of absolute acetabular component position as well as acetabular position relative to bony anatomy on patient-reported functional outcomes after primary THA.

Ipsilateral fracture dislocations of the hip and knee joints with contralateral open fracture of the leg: a rare case and its management principles

This paper discussed the injury mechanism and management of a patient who had concomitant ipsilateral hip and knee dislocations and contralateral open leg fracture.A 32-year-old man presented with ipsilateral fracturedislocations of the left hip (Pipkin's type Ⅳ) and knee (Moore Ⅱ)joints and contralateral open fracture of the leg bones after a car accident. After emergency resuscitative measures, the hip joint was reduced and Pipkin's fracture was fixed using Ganz approach with lag screws; knee joint was reduced closely and tibial plateau fracture was stabilized with lateral buttress plate and a transarticular spanning fixator. The open fracture on the other leg was debrided and fixed with an external fixator. There was no instability in both joints after fixation when he was examined under anesthesia. The fractures united after 3 months and the patient had no residual instability of hip and knee. There was no clinical or radiological evidence of osteonecrosis in the hip joint after 6 months. At one-year follow-up, he had satisfactory functional outcome with almost normal range of motion at both joints.Ipsilateral hip and knee dislocations are rare injuries and more caution is needed for early diagnosis. A timely appropriate intervention can provide good functional outcome to the patient in this situation.     

Use of a Re-entry Device in Left Subclavian Occlusion: Case Series

CardioVascular and Interventional Radiology - To describe the use of a re-entry catheter in the endovascular treatment of left subclavian stenosis. We present three patients where initial attempts...     

An unusual case of mediastinal mass in a child presenting with pneumomediastinum and air dissection in soft tissues

Pneumomediastinum and subcutaneous emphysema can occur due to various reasons but spontaneous occurrence is rare. This rare condition can occur due to a number of traumatic and non-traumatic causes. Neoplastic lesions causing pneumomediastinum are exceedingly rare. We present such a case in a child where mediastinal mass caused non-traumatic pneumomediastinum, pneumopericardium, subcutaneous and retroperitoneal emphysema. To the extent of our knowledge, this is the first reported case of mediastinal mass resulting in spontaneous air leak.