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R L Guterman N V Ramkova V A Popkov L A Sarian V Iu Reshetniak Z E Malinina N A Matorina M I Levi 《Laboratornoe delo》1989,(12):70-74
A number of chemicals have been examined to find out whether they can be employed to test the temperature regimens of vapor and hot-air sterilization methods. Test kits for various temperature ranges and different sterilization modes have been selected. It is advisable that stains be used in tests (except the sulfur one) to control vapor (but not hot-air) sterilization. 相似文献
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Mikhail Popkov Beatriz Gonzalez Subhash C. Sinha Carlos F. Barbas III 《Proceedings of the National Academy of Sciences of the United States of America》2009,106(11):4378-4383
The ability to instantly create a state of immunity as achieved in the passive transfer of hyperimmune globulin has had a tremendous impact on public health. Unlike passive immunization, active immunization, which is the foundation of vaccinology, is an anticipatory strategy with inherent limitations. Here we show that elements of active and passive immunization can be combined to create an effective chemistry-driven approach to vaccinology. Reactive immunization was used to create a reservoir of covalent polyclonal antibodies in 3 mouse strains that were subsequently engrafted with syngeneic CT26 colon or B16F10 melanoma tumors. Upon administration of designed integrin αvβ3 and αvβ5 adapter ligands, the induced covalent polyclonal antibodies self-assembled with the adapter ligands and the animals mounted an instant, chemically programmed, polyclonal response against the implanted tumors. Significant therapeutic responses were observed without recourse to adjuvant therapy. The chemically programmed immune responses were driven by antibody-dependent cellular cytotoxicity and complement-directed cytotoxicity. We suggest that this type of chemistry-driven approach to vaccinology is underexplored and may provide routes to vaccines to protect against diseases that have proven intractable to biology-driven vaccine approaches. 相似文献
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