全文获取类型
收费全文 | 1258篇 |
免费 | 54篇 |
国内免费 | 62篇 |
专业分类
耳鼻咽喉 | 22篇 |
儿科学 | 36篇 |
妇产科学 | 27篇 |
基础医学 | 136篇 |
口腔科学 | 104篇 |
临床医学 | 129篇 |
内科学 | 233篇 |
皮肤病学 | 22篇 |
神经病学 | 45篇 |
特种医学 | 94篇 |
外科学 | 235篇 |
综合类 | 23篇 |
预防医学 | 97篇 |
眼科学 | 8篇 |
药学 | 83篇 |
中国医学 | 3篇 |
肿瘤学 | 77篇 |
出版年
2022年 | 24篇 |
2021年 | 41篇 |
2020年 | 21篇 |
2019年 | 25篇 |
2018年 | 37篇 |
2017年 | 22篇 |
2016年 | 23篇 |
2015年 | 31篇 |
2014年 | 45篇 |
2013年 | 48篇 |
2012年 | 67篇 |
2011年 | 62篇 |
2010年 | 40篇 |
2009年 | 43篇 |
2008年 | 48篇 |
2007年 | 89篇 |
2006年 | 38篇 |
2005年 | 41篇 |
2004年 | 36篇 |
2003年 | 32篇 |
2002年 | 17篇 |
2001年 | 19篇 |
2000年 | 30篇 |
1999年 | 33篇 |
1998年 | 33篇 |
1997年 | 43篇 |
1996年 | 30篇 |
1995年 | 29篇 |
1994年 | 15篇 |
1993年 | 29篇 |
1992年 | 7篇 |
1991年 | 17篇 |
1990年 | 17篇 |
1989年 | 32篇 |
1988年 | 11篇 |
1987年 | 21篇 |
1986年 | 22篇 |
1985年 | 23篇 |
1984年 | 20篇 |
1983年 | 16篇 |
1982年 | 11篇 |
1981年 | 9篇 |
1980年 | 19篇 |
1979年 | 4篇 |
1978年 | 7篇 |
1976年 | 6篇 |
1975年 | 5篇 |
1973年 | 4篇 |
1970年 | 3篇 |
1966年 | 3篇 |
排序方式: 共有1374条查询结果,搜索用时 15 毫秒
41.
do Prado RF Lima CF Pontes HA Almeida JD Cabral LA Carvalho YR 《Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics》2007,104(5):e40-e44
The aim of this study was to report an unusual case of mucoepidermoid carcinoma (MEC) in a 39-year-old woman. The tumor showed a prominent population of clear and intermediate basal cells. Clear cells rarely predominate over other cell types. Such cases are called clear cell variant of MEC. The case also revealed a variable amount of calcified material in the tumor mass. Calcifications are rare in clear cell MEC. These structures were periodic acid-Schiff positive and diastase resistant, excluding glycogen origin. Immunohistochemistry was performed, and the epidermoid component was positive for cytokeratin (CK)7, CK13, CK14, and CK19. The mucous and clear cells presented mild staining for CK7. Cytokeratins 7, 13, and 19 stained luminal cells, and intermediate cells exhibited positivity for CK7, CK14, and vimentin. The origin of the calcifications is speculated to be the result of dystrophic calcification of the amorphous eosinophilic material secreted by intermediate basal cells. 相似文献
42.
43.
Danijela Stanisic Natlia L. Fregonesi Caio H. N. Barros Joo G. M. Pontes Stephanie Fulaz Ulisses J. Menezes Jorge L. Nicoleti Thiago L. P. Castro Núbia Seyffert Vasco Azevedo Nelson Durn Ricardo W. Portela Ljubica Tasic 《RSC advances》2018,8(71):40778
Caseous lymphadenitis (CL), caused by a pathogen of the second class of biosafety – Corynebacterium pseudotuberculosis, is a chronic and severe infectious disease that affects small ruminants and requires long, ineffective treatment which generally leads to animal sacrifice so as to stop the disease spreading. The infected animals suffer the excision of affected superficial lymph nodes and post-surgical treatment with iodine (10% solution in ethanol) and, sometimes, prolonged antibiotic use, but only if the sick animals are of great importance to breeding. Herein, we propose a cheap and easy to apply treatment of CL with excellent results using biogenic silver nanoparticles (AgNP) based technology. AgNP antibacterial properties were investigated in vitro against Corynebacterium pseudotuberculosis cells and in vivo on small ruminants with CL. Treatment of surgical wounds resulting from the excision of superficial CL lesions with a AgNP-based cream was compared to the standard post-surgical treatment method by iodine. Also, the effects of AgNP-based cream treatment were evaluated and compared with the effects of the iodine CL treatment by serum NMR-based metabolomics. Serum samples were collected from 29 animals, 9 sheep and 20 goats, during the treatments and analyzed. All animals showed stable serum metabolomes when iodine or AgNP-based cream effects were compared. The AgNP-based cream treatment showed excellent results, especially in accelerating the healing of wounds, which occurred two to three times faster in comparison with the iodine treatment. AgNP-based cream treatment also prevented CL reappearance and did not cause any side effects on animals. This is the first report on very effective post-surgical treatment of superficial CL in small ruminants based on biogenic silver nanoparticles, which might open up the possibility for a safe veterinary application of AgNP-based cream.Biogenic nanosilver in a pharmaceutical cream for wound healing in animal and human healthcare. 相似文献
44.
45.
Hugo Jário de Almeida Silva José Cortez Assunção Júnior Franciele Santos de Oliveira Jaine Maria de Pontes Oliveira Glauko André Figueiredo Dantas Caio Alano de Almeida Lins Marcelo Cardoso de Souza 《Journal of bodywork and movement therapies》2019,23(2):382-389
IntroductionPhysical training has been recommended to improve overall well-being in patients with fibromyalgia. Body relaxation exercises also seem to have some beneficial effect, however there is no consensus regarding this modality.ObjectiveComparing the effectiveness of sophrology and resistance training in improving the pain of women with fibromyalgia.MethodA randomized controlled clinical trial with a blind evaluator. Sixty (60) women with a medical diagnosis of fibromyalgia were randomized and included in two groups: sophrology group (SG) who participated in a relaxation program based on sophrology (n = 30), and resistance group (RG) (n = 30) who participated in a resistance training program for biceps, pectoral, triceps, knee extensors, trapezius, knee flexors, hip abductors. Both groups were treated twice a week for 12 weeks and reevaluated every 4 weeks. The assessment instruments used were the Visual Analog Scale for Pain (VAS), the one-repetition maximum test (1 RM), the overall quality of life (SF-36), the 6-min walk test (6MWT), the Timed Up and Go test (TUG) and the Fibromyalgia Impact Questionnaire (FIQ).ResultsWe found that the RG presented statistically significant decreases in pain (VAS) during the evaluations (p < 0.05) and increased strength of the evaluated muscles (p < 0.05). A statistically significant decrease in pain (p < 0.05) was observed in the SG compared to T0, with no significant differences in muscle strength. Differences between groups were observed, with better indices only for 6MWT and functional capacity domain of the SF36 for the RG (p < 0.05).ConclusionNo differences in pain were found between the groups. Resistance training was more effective than sophrology in improving strength and functional capacity of women with fibromyalgia. 相似文献
46.
Gazitt Y; Tian E; Barlogie B; Reading CL; Vesole DH; Jagannath S; Schnell J; Hoffman R; Tricot G 《Blood》1996,87(2):805-811
Peripheral blood stem cells (PBSCs) mobilized with high-dose chemotherapy and hematopoietic growth factors are now widely used to support myeloablative therapy of multiple myeloma and effect complete remissions in up to 50% of patients with apparent extension of event- free and overall survival. Because tumor cells are present not only in bone marrow, but also in virtually all PBSC harvests, it is conceivable that autografted myeloma cells contribute to relapse after autotransplants. In this study, the kinetics of mobilization of normal hematopoietic stem cells were compared with those of myeloma cells present in PBSC harvests of 12 patients after high-dose cyclophosphamide and granulocyte-macrophage colony-stimulating factor administration. CD34+ and CD34+Lin-Thy+ stem cell contents were measured by multiparameter flow cytometry, and myeloma cells were quantitated by immunostaining for the relevant Ig light chain and by a quantitative polymerase chain reaction for the myeloma-specific CDRIII sequence. Results indicated marked heterogeneity in the percentages of mobilized stem cells among different patients (0.1% to 22.2% for CD34+ cells and 0.1% to 7.5% for CD34+Lin-Thy+ cells, respectively). The highest proportions of hematopoietic progenitor cells were observed early during apheresis, with 9 of 12 patients mobilizing adequate amounts of CD34+ cells for 2 autotransplants (> 4 x 10(6)/kg) within the first 2 days, whereas peak levels (percent and absolute numbers) of myeloma cells were present on days 5 and 6 (0.5% to 22.0%). During the last days of collection, mobilized tumor cells exhibited more frequently high labeling index values (1% to 10%; median, 4.4%) and an immature phenotype (CD19+). The differential mobilization observed between normal hematopoietic stem cells and myeloma cells can be exploited to reduce tumor cell contamination in PBSC harvests. 相似文献
47.
L de P Castro A Bettarello A V Pessoa F E Vieira I B Paes I Maguilnik J Pereira-Lima J F Pontes J F Penteado J C Pisani 《Arquivos de gastroenterologia》1990,27(1):3-9
This prospective multicentric randomized open trial was designed to evaluate the efficacy of ranitidine 150 mg bid vs 300 mg nocte in the short-term (4 weeks) treatment of duodenal ulcer in 15 Brazilian centers. On the basis of a randomization table 190 patients with endoscopically confirmed duodenal ulcer were allocated to receive either ranitidine 150 mg bid (94 pts) or 300 mg nocte (96 pts). The 2 treatment groups were well matched for age, sex, duration of ulcer disease, number and size of ulcers, duration of current episode, intensity of ulcer pain, alcohol and coffee intake and smoking habits. They were endoscopically controlled at the end of the 4 weeks. At 4 weeks 78 of 94 patients (83.0%) had their ulcers healed with the 150 mg bid regimen as opposed to 79 of 96 patients (82.3%) allocated to the 300 mg nocte dosage. This difference was not statistically significant. Ulcer symptoms diminished with treatment in both groups. The tolerability and compliance was excellent in both groups. The results show that ranitidine 300 mg nocte is as effective in the short-term treatment of duodenal ulcer as ranitidine 150 mg bid. Considering the greater simplicity of administration enhancing patient compliance, the treatment with 300 mg nocte is preferable. 相似文献
48.
Etoposide is one of the most widely used antineoplastics. Unfortunately, the same treatment schedules associated with impressive efficacy are associated with an increased risk of secondary acute myeloid leukemia (AML), which has prompted its withdrawal from some treatment regimens, thereby potentially compromising efficacy against the original tumor. Because etoposide-associated AML is characterized by site-specific illegitimate DNA recombination, we studied whether etoposide could directly cause site-specific deletions of exons 2 and 3 in the hprt gene. Human lymphoid CCRF-CEM cells were treated with etoposide for 4 hours, and DNA was isolated after subculturing. The deletion of exons 2 and 3 from hprt was assayed by a quantitative polymerase chain reaction (PCR) method. In the absence of etoposide treatment, the frequency of deletions of exons 2 and 3 was very low (5.05 x 10(-8)). After exposure to 10 mumol/ L etoposide, the frequency of the exon 2 + 3 deletion was increased immediately after and at 24 hours after etoposide treatment (65 to 89 x 10(-8)) and increased to higher levels (128 to 173 x 10(-8)) after 2 and 6 days of subculture (P < .001 overall). The frequency of the exon 2 + 3 deletion assessed at 6 days of subculture after 4 hours of 0, 0.25, 1, 2.5, 5, and 10 mumol/L etoposide treatment increased with etoposide concentration, ie, 5.05 x 10(-8), 89.2 x 10(-8), 108 x 10(-8), 142 x 10(-8), 163 x 10(-8), and 173 x 10(-8), respectively (P < .0001). Sequencing of a subset of amplified products confirmed the presence of DNA sequences at the breakpoints consistent with V(D)J recombination. By contrast, exon 2 + 3 deletions after etoposide treatment in the myeloid cell lines KG-1A and K562 showed no evidence of V(D)J recombinase in their genesis. We conclude that etoposide can induce the illegitimate site-specific action of V(D)J recombinase on an unnatural DNA substrate after a single treatment in human lymphoid cells. 相似文献
49.
Auricelio Batista Cezar-Junior Igor Vilela Faquini Jos Laercio Junior Silva Eduardo Vieira de Carvalho Junior Luiz Euripedes Almondes Santana Lemos Joo Batista Monte Freire Filho Hetevaldo Tavares de Lira Filho Erton Cesar de Albuquerque Pontes Nivaldo Sena Almeida Hildo Rocha Cirne Azevedo-Filho 《Medicine》2020,99(51)
Some evidences suggest the involvement of the central nervous system in patients infected with SARS-CoV-2. We aim to analyze possible associations between coronavirus disease 2019 (COVID-19) pandemic and spontaneous subarachnoid hemorrhage (SAH), in a comprehensive neurological center.We conducted a retrospective case series of 4 patients infected by COVID-19, who developed spontaneous SAH. Clinical data were extracted from electronic medical records.Between March 24, 2020, and May 22, 2020, 4 cases (3 females; 1 male) of SAH were identified in patients infected with SARS-CoV-2, in a comprehensive neurological center in Brazil. The median age was 55.25 years (range 36 -71). COVID-19-related pneumonia was severe in 3 out of 4 cases, and all patients required critical care support during hospitalization. The patients developed Fisher grade III and IV SAH. Digital subtraction angiography (DSA) was performed in 3 of the 4 patients. However, in only 1 case, an aneurysm was identified. Inflammatory blood tests were elevated in all cases, with an average D-dimer of 2336 μg/L and mean C-reactive protein (CRP) of 3835 mg/dl The outcome was poor in the majority of the patients, with 1 death (25%); 2 (50%) remained severely neurologically affected (mRS:4); and 1 (25%) had slight disability (mRS:2).This study shows a series of 4 rare cases of SHA associated with COVID-19. The possible mechanisms underlying the involvement of SARSCoV-2 and SHA is yet to be fully understood. Therefore, SHA should be included in severe neurological manifestations in patients infected by this virus. 相似文献
50.
Flavia Sirotheau Corrêa Pontes PhD Felipe Paiva Fonseca Adriana Souza de JesusLeila Marques Araújo MSc Liliane Silva do Nascimento Hélder Antônio Rebelo Pontes 《Journal of endodontics》2014