不同剂量HCG对体外受精-胚胎移植的影响

目的 :比较使用不同剂量人绒毛膜促性腺激素 (HCG)对体外受精 /胞浆内单精子注射 (IVF/ICSI)的结局及对卵巢过度刺激综合征 (OHSS)发病率的影响。方法 :对在本所接受IVF/ICSI辅助生育的 2 6 2例采用GnRH a长方案促排卵的患者进行回顾性分析 ,按HCG用量分为A组 (HCG 5 0 0 0～ 6 0 0 0U)、B组 (HCG 80 0 0～ 10 0 0 0U)。结果 :两组临床妊娠率分别为 35 .94 %和 38.0 5 % (P >0 .0 5 ) ,OHSS发生率分别为 2 .34%和 4 .4 8% (P >0 .0 5 )。结论 :减少HCG用量后对IVF/ICSI的临床妊娠率无明显影响 ,且可以减少OHSS的发生。     

胃癌患者血清肝细胞生长因子的检测及意义

Objective To explore the clinical significance of serum HGF level changes in gastric cancer pa-tients. Methods 60 cases of patients who operatied and clinicopathological confirmed gastric cancer, were detected serum HGF level by enzyme linked immunosorbent assay(ELISA) .40 cases were administered radical gastrectomy,20 cases of patients who had distant metastasis and loss operative chance were detected 7 days and 3 months preopera-tive,postoperative serum HGF level respectively. At the same time 40 cases of chronic gastritis patients and 40 cases of healthy examination people were selected as control group. Results Serum HGF level in patients with gastric canc-er was significantly higher than that of chronic gastritis and normal controls(P <0. 01). The serum HGF level of pa-tients with tumor vascular invasion significantly increased(P <0. 05). The patients with lymph node metastasis,serum HGF level was significantly higher than that patients with no lymph node metastasis(P <0. 05). The serum HGF level of patients with liver metastasis was significantly higher than that patients with no liver metastasis(P <0. 05). The se-rum HGF level of gastric cancer patients whose maximum diameter of the tumor ≥3cm were significantly higher than that maximum diameter of the tumor <3cm(P<0. 05). According to TNM staging of gastric cancer,the serum HGF level of Ⅰ phase and Ⅱ phase patients were significantly lower than that Ⅲ phase and Ⅳ phase patients(P <0.05).The serum HGF level of gastric cancer patients had no significant correlation with sex ,age and histological type(P <0.05). The serum HGF level of 40 cases of patients who were 1 week after surgery were significantly decreased,the patients who were 3 months after surgery were more obvious(P <0. 05 and P <0. 001). Conclusion HGF may play an important role in gastric cancer occurrence and development. The detection of serum HGF level can become an im-portant index for monitoring the degree of gastric cancer and prognosis of patients.     

73例70岁以上妇女妇科恶性肿瘤手术分析

[目的]探讨70岁以上妇科恶性肿瘤患者手术的耐受情况。[方法]收集浙江省肿瘤医院自1996年1月到2001年12月间,70岁以上妇科恶性肿瘤患者接受盆腔姑息性和根治性手术治疗73例,分析不同年龄及手术范围对术后恢复的影响。[结果]73例患者66例选择了根治性手术,7例接受姑息性手术。术后70~75岁组和>75岁组,其手术方式、平均住院时间、术前术后并发症等无明显差别。术中出血量、手术时间及并发症发生率均明显较姑息性手术组增加,12例严重并发症中,11例发生在根治性手术组。[结论]经过严密的术前准备、术后处理,70岁以上的老年妇女能够耐受根治性手术治疗。     

EXPRESSION OF p16,CYCLIN D1 AND RB PROTEIN IN GASTRIC CARCINOMA AND PREMALIGNANT LESIONS

Gastric carcinoma is one of the most serious diseases in mankind. Its pathogenesis has not been understood very clearly. Recent researches suggested that oncogenes (such as cyclin D1), antioncogenes (ie., p16, Rb) and cell cycle played an important role in the pathogenesis of gastric carcinoma. But there are few reports about the relationship between these genes in gastric carcinoma and gastric premalignant lesions. In this study, we will discuss these problems. MATERIALS AND METHO…     

喉癌、下咽癌颈廓清组织中转移淋巴结的分布研究

对54侧经临床检查或／和CT扫描确诊为有淋巴结转移而行预廓清的标本进行病理学观察，发现：喉癌、下咽癌淋巴结转移有一定规律可循，即LevelⅡ、Ⅲ有较高的转移率，LevelⅣ、Ⅵ的发生率较低，而LevelⅠ、LevelⅤ很少发生转移。提示：喉癌、下咽癌病人的颈廓清的施术应在颈LevelⅡ～Ⅳ廓清的同时行同侧甲状腺侧叶的切除以将颈中器官周围淋巴结清扫彻底。对LevelⅠ，LevelⅤ的清扫应在临床触诊、CT检查的证实下或术中发现转移时方可进行．以减少颈廓清手术范围、手术时间和术后并发症的发生。     

氯硝安定与安定溶液直肠给药用于惊厥急救的对照研究

目的以安定为对照，探讨氯硝安定溶液直肠给药对惊厥急救的实用价值。方法在２８例儿童中对比观察直肠注入氯硝安定与安定溶液的吸收速度和对脑电活动的影响，并比较两药对大鼠实验性惊厥的疗效。结果氯硝安定与安定溶液均能从直肠迅速吸收，皆于用药５分钟后达有效血浓度，分别于３～８分钟及２～８分钟对脑电活动产生显著影响，明显抑制癫痫样波发放，使美解眠诱发的惊厥致死率从对照组的７０％降为０。结论氯硝安定与安定溶液直肠给药，均能作为小儿惊厥抢救的有效措施。     

国人（195例）重心动摇计检查正常值的测定

目的：为测得正常中国人重心动摇检查各项正常值。方法：１９５例无晕与平衡障碍的人行重心动摇检查，得到各项测试值，结果：与日本学会标准比较，睁眼与闭眼外周面积值各年龄组无益氏于日本学会标准，其余各项数值相仿。结论；国人重心动摇应参照中国人的正常值。     

鼻窦骨结构变异及其临床意义(鼻窦CT扫描分析)

目的：进一步探讨鼻窦骨结构变异与鼻窦炎发生的关系。方法：对109例临床疑为鼻窦炎患者进行鼻窦冠状位CT扫描。结果：鼻窦粘膜异常改变者93例（85.3％），16例粘膜呈正常影像（14.7％）。在93例鼻窦粘膜异常改变者中，鼻窦骨结构变异为70例（75．3％），其中Haller气房出现率为31.2％，中鼻甲气化为31．2％，中鼻甲反和弯曲为10．8％，钩突气化为2．2％。结论：鼻窦骨结构变异可能是鼻窦炎致病因素之一，鼻窦炎患者骨结构变异情况应对每个患者进行具体分析，同时也要考虑到其它致病因素。     

Synovial sarcoma in childhood: Clinical and radiological findings

Objective: To study the clinical characteristics andradiological features of synovial sarcoma in childhood and its relation to the diagnosis and treatment. Methods: The clinical radiological features of 15 children with synovial sarcoma proved surgically and pathologically were analyzed. Results: In children, the tumor boundaries are poorly defined due to paucity of fat, and metastasis usually occurs early. Eight patients in this series had bone involvement, including: direct erosion by tumor causing cortical destruction, indirect pressure defect with sharp margin and reactive bone sclerosis and bone destruction of the primary intraosseous synovial sarcoma. Conclusion: The tumor is often misdiagnosed, the final confirmed diagnosis must be made by histological examination with imaging findings. It is emphasized that the patients should be treated with radiotherapy and chemotherapy preoperatively and postoperatively.     

Focal cerebral ischemia alters the spatio-temporal properties, but not the amount of locomotor activity in mice

Cerebral ischemia induces hyperlocomotion in gerbils, and sensorimotor and cognition dysfunctions in rodents ; however little is known about the spatio-temporal organization of locomotor activity after ischemia. In this study, we continuously （22 h） assessed the spatio-temporal organization of locomotor activity in focal cerebral ischemic mice in an open field with feeding and drinking supplies. To observe the spatio-temporal changes,