全文获取类型
收费全文 | 25787篇 |
免费 | 1759篇 |
国内免费 | 169篇 |
专业分类
耳鼻咽喉 | 206篇 |
儿科学 | 576篇 |
妇产科学 | 473篇 |
基础医学 | 3677篇 |
口腔科学 | 259篇 |
临床医学 | 2320篇 |
内科学 | 6053篇 |
皮肤病学 | 328篇 |
神经病学 | 2534篇 |
特种医学 | 865篇 |
外国民族医学 | 1篇 |
外科学 | 4773篇 |
综合类 | 160篇 |
一般理论 | 9篇 |
预防医学 | 1577篇 |
眼科学 | 286篇 |
药学 | 1575篇 |
中国医学 | 77篇 |
肿瘤学 | 1966篇 |
出版年
2023年 | 121篇 |
2022年 | 245篇 |
2021年 | 493篇 |
2020年 | 361篇 |
2019年 | 597篇 |
2018年 | 648篇 |
2017年 | 492篇 |
2016年 | 538篇 |
2015年 | 631篇 |
2014年 | 885篇 |
2013年 | 1209篇 |
2012年 | 1816篇 |
2011年 | 1960篇 |
2010年 | 1191篇 |
2009年 | 1124篇 |
2008年 | 1722篇 |
2007年 | 1767篇 |
2006年 | 1654篇 |
2005年 | 1728篇 |
2004年 | 1525篇 |
2003年 | 1551篇 |
2002年 | 1575篇 |
2001年 | 226篇 |
2000年 | 189篇 |
1999年 | 257篇 |
1998年 | 336篇 |
1997年 | 320篇 |
1996年 | 226篇 |
1995年 | 221篇 |
1994年 | 174篇 |
1993年 | 172篇 |
1992年 | 141篇 |
1991年 | 127篇 |
1990年 | 120篇 |
1989年 | 91篇 |
1988年 | 89篇 |
1987年 | 69篇 |
1986年 | 103篇 |
1985年 | 87篇 |
1984年 | 97篇 |
1983年 | 93篇 |
1982年 | 102篇 |
1981年 | 90篇 |
1980年 | 88篇 |
1979年 | 56篇 |
1978年 | 45篇 |
1977年 | 39篇 |
1976年 | 37篇 |
1975年 | 36篇 |
1974年 | 35篇 |
排序方式: 共有10000条查询结果,搜索用时 0 毫秒
91.
Aneurysm of the abdominal aorta in an eighteen-month-old child 总被引:1,自引:0,他引:1
Jean Olivier Defraigne MD Jean Pierre Paquot MD Etienne Creemers MD Raymond MD Limet 《Annals of vascular surgery》1988,2(2):193-195
We report the case of an infected aneurysm of the abdominal aorta in a 18 month-old child, discovered by routine palpation of the abdomen during hospitalization for pneumonia. Ultrasonography and arteriography showed a 6 cm aneurysm of the abdominal aorta beginning distal to the renal arteries which occluded the right common Iliac artery. The aneurysm was treated by interposing a 6 mm Gore-Tex graft between the infrarenal aorta and the aortic bifurcation. Pathologic examination of the aneurysmal wall demonstrated a leukocytic Infiltrate and the presence of encapsulated Gram positive organisms. Arterial aneurysms are exceedingly rare in children. Their etiology is varied: infection, connective tissue disease, trauma, inflammatory arterial disease or other rare diseases such as tuberous sclerosis, neurofibromatosis, or Beçhet’s disease. 相似文献
92.
93.
C Meyer-Bisch Q T Pham J M Mur N Massin J J Moulin D Teculescu B Carton F Pierre F Baruthio 《British journal of industrial medicine》1989,46(5):302-309
A cross sectional study was conducted on 513 employees at three hard metal plants: 425 exposed workers (351 men, 74 women) and 88 controls (69 men, 19 women). Cough and sputum were more frequent in workers engaged in "soft powder" and presintering workshops compared with controls (12.5% and 16.5% v 3.5%). Spirometric abnormalities were more frequent among women in sintering and finishing workshops compared with control women (56.8% v 23.8%) and abnormalities of carbon monoxide test were more frequent in exposed groups than in controls; this difference was more pronounced in women (31.4% v 5.6%) than in men (18.5% v 13%). No significant correlation was observed between duration of exposure and age adjusted lung function tests. Slight abnormalities of chest radiographs (0/1, 1/1 according to ILO classification) were more frequent in exposed men than controls (12.8% v 1.9%) and mostly in soft powder workers. In subjects with abnormal chest radiographs FVC, FEV1 and carbon monoxide indices (fractional uptake of CO or CO transfer index or both) were lower compared with those with normal chest radiographs. Although relatively mild, the clinical, radiological, and functional abnormalities uncovered call for a regular supervision of workers exposed to hard metal dust. 相似文献
94.
Pierre Lachapelle Julie Benoit John M. Little Jocelyn Faubert 《Documenta ophthalmologica. Advances in ophthalmology》1989,73(4):327-336
Of all the electroretinogram (ERG) components (a-wave, b-wave, and oscillatory potentials) only one oscillatory potential, OP2, was found to be significantly correlated with the absolute intensity of the flash stimulus (i.e., the intensity of the stimulus irrespective of the state of retinal adaptation). Our finding was further confirmed in single cell recordings of lateral geniculate unit activity in rabbits in which peak time of OP2 was found to correlate better with the geniculate activity. For these reasons we have identified OP2 as the intensity coding oscillatory potential of the ERG. In order to investigate if this new feature could have some clinical significance, we examined photopic ERGs recorded from patients affected with various retinopathies. In most instances the peak time of OP2 paralleled that of the b-wave, that is, in the ERG with delayed b-wave the peak time of OP2 was also delayed, while in ERGs with normal b-wave peak time the peak time of OP2 was also normal. However, in some conditions (especially in cone-rod diseases) a delayed OP2 was found in ERGs with normal b-wave peak times. 相似文献
95.
MIM/BEG4, a Sonic hedgehog-responsive gene that potentiates Gli-dependent transcription 总被引:7,自引:0,他引:7
Callahan CA Ofstad T Horng L Wang JK Zhen HH Coulombe PA Oro AE 《Genes & development》2004,18(22):2724-2729
96.
Karly Hampshire Pierre‐Marie Martin Colleen Carlston Anne Slavotinek 《American journal of medical genetics. Part A》2020,182(8):1923-1932
Baraitser–Winter cerebrofrontofacial syndrome (BWCS) is a rare, autosomal dominant condition that is characterized by intellectual disability, distinctive craniofacial features, structural brain abnormalities, seizures, microcephaly, hearing loss, and ocular colobomas. The first three cases were described in 1988 by Baraitser and Winter and included two siblings and an unrelated third patient. Subsequently, causative missense variants in the ACTB and ACTG1 genes were identified, with de novo occurrence in patients with the condition. Herein, we describe two adult siblings who were born to unaffected parents and who were diagnosed with BWCS in their fourth and sixth decade of life following exome sequencing performed for intellectual disability. We review the literature reports of adult patients with BWCS to document the clinical features and phenotypic variability that can occur later in life. This is the first molecularly confirmed report of germline mosaicism in BWCS and one of only a few reports to describe two BWCS patients belonging to the same family. 相似文献
97.
Jacqueline Girard Nam Hai Chua Pierre Bennoun Gregory Schmidt Monique Delosme 《Current genetics》1980,2(3):215-221
Summary Genetic analysis of 25 nuclear mutants defective in the chlorophyll-protein complex CP1 was undertaken. The mutants belong to 13 complementation groups scattered throughout the nuclear genome. All these mutants lack the apoprotein of CP1 and, in addition, a specific set of six low molecular weight thylakoid polypeptides. System I particles obtained by treating WT thylakoid membranes with detergent specifically contain those polypeptides which the mutants lack. These observations suggest that a particular sub-structure of the thylakoid membrane associated with the photosystem I activity is missing from all 25 mutants studied, and that this general phenotype can result from mutation at any one of several unlinked Mendelian loci. 相似文献
98.
Allegria Kessous Pierre Colombies Martine Sudries Georges Bourrouillou Jacques Pris Danielle Clement 《Cancer Genetics and Cytogenetics》1980,2(4):335-337
This report describes a new case of chronic myeloid leukemia with an unusual Philadelphia chromosome translocation involving chromosomes No. 4,9, and 22; t(4,9,22) (q31;q34;q11). 相似文献
99.
Norbert B Ghyselinck Nadège Vernet Christine Dennefeld Norbert Giese Heinz Nau Pierre Chambon Stéphane Viville Manuel Mark 《Developmental dynamics》2006,235(6):1608-1622
Using Rbp4-null mice as models, we have established for the first time the kinetics of the spermatogenetic alterations during vitamin A deficiency (VAD). Our data demonstrate that the VAD-induced testicular degeneration arises through the normal maturation of germ cells in a context of spermatogonia differentiation arrest. They indicate that retinoic acid (RA) appears dispensable for the transition of premeiotic to meiotic spermatocytes, meiosis, and spermiogenesis. They confirm that RA plays critical roles in controlling spermatogonia differentiation, spermatid adhesion to Sertoli cells, and spermiation, and suggest that the VAD-induced arrest of spermatogonia differentiation results from simultaneous blocks in RA-dependent events mediated by RA receptor gamma (RARgamma) in spermatogonia and by RARalpha in Sertoli cells. They also provide evidence that expression of major RA-metabolizing enzymes is increased in mouse Sertoli cells upon VAD and that vitamin A-deficient A spermatogonia differ from their RA-sufficient counterparts by the expression of the Stra8 gene. 相似文献
100.
Etienne O Gasnier C Taddei C Voegel JC Aunis D Schaaf P Metz-Boutigue MH Bolcato-Bellemin AL Egles C 《Biomaterials》2005,26(33):6704-6712
The surface of medical devices is a common site of bacterial and fungal adhesion, first step to the constitution of a resistant biofilm leading frequently to chronic infections. In order to prevent such complications, several physical and chemical modifications of the device surface have been proposed. Here, we experiment a new type of topical antifungal coating using the layer-by-layer technique. The nanometric multilayer film obtained by this technique is functionalized by the insertion of a chromogranin A-derived antifungal peptide (CGA 47-66, chromofungin). We show that the embedded peptide keeps its antifungal activity by interacting with the fungal membrane and penetrating into the cell. In vitro studies demonstrate that such an antifungal coating is able to inhibit the growth of yeast Candida albicans by 65% and completely stop the proliferation of filamentous fungus Neurospora crassa. The cytotoxicity of such a coating was also assessed by growing human gingival fibroblasts at its surface. Finally, the antifungal coating of poly(methylmethacrylate), a widely used material for biomedical devices, is successfully tested in an in vivo oral candidiasis rat model. Taken together, these results assessed the functionalized multilayer films containing a new potent antifungal non-toxic peptide, as a novel and promising technique for local antifungal protection. 相似文献