Correction to: Validation of Rapid Antimicrobial Susceptibility Testing directly from blood cultures using WASPLab®, including Colibrí™ and Radian® in-Line Carousel

European Journal of Clinical Microbiology & Infectious Diseases -     

A HER2 target antibody drug conjugate combined with anti-PD-(L)1 treatment eliminates hHER2+ tumors in hPD-1 transgenic mouse model and contributes immune memory formation

Breast Cancer Research and Treatment - Disitamab vedotin (RC48) is an HER2-directed antibody–drug conjugate, emerging as an effective strategy for cancer therapy, which not only enhances...     

Bibliometric profile of neurogenic bladder in the literature: a 20-year bibliometric analysis

Neurogenic bladder is a dysfunction of the lower urinary tract caused by nervous system disorder. We investigated the trends in publication of articles under the topic “neurogenic bladder” using bibliometric analysis. Articles on neurogenic bladder, published between 1995 and 2014, were retrieved from the ISI Web of Science citation database. We analyzed the search results for authors, countries, institutions, journals, and top-cited papers. A total of 1,904 articles were retrieved. There was a small increase in the number of articles on neurogenic bladder from 1995 (n = 43) to 2014 (n = 117). The USA was the leading country in the total number of articles (n = 598). However, the number of publications from China has rapidly increased, and China was ranked second in 2014. Emmanuel Chartier-Kastler (n = 65) was the most productive author, and University of Paris VI (Paris 6) (n = 61) was the most productive institution. The Journal of Urology published the greatest number of articles on this topic (n = 285). Articles on neurogenic bladder were often published in a professional journal under the category Urology & Nephrology, Neurosciences & Neurology, or Rehabilitation. Visualization analysis based on co-citation networks was conducted using CiteSpace III. Visualization analysis revealed that the hot spots in neurogenic bladder were botulinum toxin-A, prazosin, bethanechol, and afferent pathways. These findings provide new insight into the publication trends and hot spots in neurogenic bladder.     

Patterns of aluminum hydroxychloride deposition onto the skin

Background: Aluminum hydroxychloride (AlCl₃) is an antiperspirant. Aim: To revisit the AlCl₃ deposition in vivo and in vitro on glass slides and stratum corneum (SC) harvested by cyanoacrylate skin surface strippings (CSSS). Methods: Transepidermal water loss (TEWL) was assessed following application of 5% AlCl₃ on the forearms. The AlCl₃‐coated skin, glass slides and CSSS were observed using two ultraviolet light‐emitting CCD cameras in order to record changes in specular reflectance related to AlCl₃ deposition. In addition, the corneoxenometry bioassay was performed in order to predict AlCl₃ irritation. Results: AlCl₃ deposited on glass slides looked as linear threads and rings of similar sizes. AlCl₃ deposits on skin were almost restricted inside the microrelief lines and as annular deposits at their crossings where acrosyringia are opening. After daily AlCl₃ applications, deposits extended on the CSSS plateaus. At rest in absence of sweating, TEWL was decreased following AlCl₃ applications. During physical exercise, the TEWL increase was limited on the AlCl₃ areas. CSSS appeared unreactive to AlCl₃ at the corneoxenometry bioassay. Conclusion: The similar aspect of AlCl₃ deposits on human SC and on glass slides suggested a physical property of AlCl₃. Repetitive applications of AlCl₃ increased both the deposit area and the barrier function.     

Comparative effects of retinoic acid, glycolic acid and a lipophilic derivative of salicylic acid on photodamaged epidermis.

BACKGROUND: Studies comparing purported antiaging compounds are rare. OBJECTIVE: To compare in a randomized, placebo-controlled double-blind study 10% glycolic acid (GA), 2% 2-hydroxy-5-octanoyl benzoic acid (beta-lipohydroxy acid, LSA) and 0.05% all-trans-retinoic acid (RA). METHODS: Women volunteers treated one forearm twice daily with one of the active products and the other one with the vehicle. Comparative evaluations of efficacy were made using histochemistry and quantitative immunohistochemistry. RESULTS: Improvement in the various epidermal compartments was the most prominent finding at the RA-treated site. The LSA-treated site also exhibited similar positive changes, although to a lesser degree. GA showed no significant effect. CONCLUSION: In the presently tested concentrations and formulations, RA had a beneficial impact upon the aging epidermis. LSA mimicked RA but with somewhat lesser efficacy. By contrast, GA appeared almost inactive.     

Fractal quantification of the microvasculature heterogeneity in cutaneous melanoma.

BACKGROUND: Recent advances in angiogenesis research have led to the introduction of new prognosis factors. Although the vessel count is effective in breast cancer, the prognosis of primary cutaneous melanoma (PCM) does not seems to be directly influenced by this parameter. However, the microscopic examination of PCM suggests variability in the repartition of the microvasculature. OBJECTIVE AND METHOD: To explore the possibility of extracting information about the vessel distribution by performing a textural analysis on the grey level of histological sections by means of fractal characterization by both Fourier spectrum and multifractal analysis. RESULTS: Three different patterns of vasculature were identified according to the vessel density and distribution. CONCLUSION: It is possible to differentiate and quantify clearly the differences in the microvessel profile organization using the fractal and multifractal methods.     

EEMCO guidance to the in vivo assessment of tensile functional properties of the skin. Part 1: relevance to the structures and ageing of the skin and subcutaneous tissues.

From an engineering point of view, the skin and subcutaneous tissue represent an integrated load-transmitting structure. It is subjected to intrinsic and environmental influences. An attempt to use a four-layered model is offered to explain how the integument withstands and transmits loads through deforming appropriately. The stratum corneum, the association between the living epidermis and papillary dermis, the reticular dermis and the hypodermis have each their own intimate structures whose tensile functions are ideally balanced to respond adequately to the casual mechanical demands. A series of physiological variables, ageing and skin diseases alter the tensile functions of the organ. In the overall analysis, truly comprehensive multidisciplinary approaches in this field have brought advances in the understanding of functional skin biology. The assessment of tensile functions of skin also provides incentives for progress in skin care.     

Postural skin colour changes during the corticosteroid blanching assay.

OBJECTIVE: To assess the effect of the position of a limb (dependency) on the cutaneous vasoconstrictor (blanching) assay (VCA) using topical corticosteroid preparations. METHOD: Two studies were performed on the forearms of healthy volunteers using tristimulus reflectance colorimetric assessments. The first one conducted in 60 normal adults aimed at quantifying the range of variation in the skin chromaticity a* when the arm was successively positioned horizontally and vertically, either in the upward or downward direction. In the second study, 16 volunteers were selected according to a weak spontaneous postural dependency of the limb in a* (<2 units). The blanching effect of 0.1% mometasone furoate, 0.1% betamethasone valerate and petrolatum were compared to the colour of an untreated site. Chromaticity a* and the colorimetric variable (DeltatL*(2) + Deltata*(2))(0.5) were measured in time following a 2-hour application. RESULTS: The postural variations in skin colour varied among subjects. The majority of them (80%) presented a difference in a* higher than 2 units between the upright and downward arm positions. The upright position appeared to be the most sensitive to show significant differences in the VCA. Mometasone furoate exhibited the most prominent effect, significantly higher than betamethasone valerate and controls. CONCLUSION: The corticosteroid VCA is influenced by the position of the limb. The upright position increases the sensitivity of the test. Mometasone furoate is more potent than betamethasone valerate.