全文获取类型
收费全文 | 113篇 |
免费 | 9篇 |
专业分类
儿科学 | 8篇 |
妇产科学 | 2篇 |
基础医学 | 16篇 |
口腔科学 | 1篇 |
临床医学 | 7篇 |
内科学 | 13篇 |
皮肤病学 | 2篇 |
神经病学 | 6篇 |
特种医学 | 14篇 |
外科学 | 7篇 |
预防医学 | 3篇 |
眼科学 | 1篇 |
药学 | 19篇 |
肿瘤学 | 23篇 |
出版年
2023年 | 1篇 |
2022年 | 1篇 |
2021年 | 3篇 |
2018年 | 3篇 |
2017年 | 1篇 |
2016年 | 2篇 |
2015年 | 4篇 |
2014年 | 4篇 |
2013年 | 11篇 |
2012年 | 4篇 |
2011年 | 8篇 |
2010年 | 5篇 |
2009年 | 6篇 |
2008年 | 9篇 |
2007年 | 3篇 |
2006年 | 5篇 |
2005年 | 3篇 |
2004年 | 4篇 |
2003年 | 1篇 |
2001年 | 2篇 |
2000年 | 3篇 |
1998年 | 6篇 |
1997年 | 11篇 |
1996年 | 4篇 |
1995年 | 1篇 |
1994年 | 2篇 |
1993年 | 1篇 |
1992年 | 3篇 |
1991年 | 1篇 |
1989年 | 1篇 |
1986年 | 1篇 |
1985年 | 1篇 |
1977年 | 1篇 |
1976年 | 3篇 |
1975年 | 1篇 |
1967年 | 1篇 |
1965年 | 1篇 |
排序方式: 共有122条查询结果,搜索用时 15 毫秒
41.
A case of well-differentiated minute hepatocellular carcinoma with extrahepatic metastasis 总被引:1,自引:0,他引:1
SOO RYANG KIM YOSHITAKE HAYASHI TOSHIYUKI MATSUOKA SOK YONG PARK SHIGEYUKI SHINTANI KAZUNORI SASAKI JUN ASANO JUNG HYO KIM KE IH KIM SUSUMU IMOTO HIROSHI ITOH MASATOSHI KUDO 《Journal of gastroenterology and hepatology》1998,13(9):892-896
A rare case of well-differentiated minute hepatocellular carcinoma (HCC) metastasizing to distant sites in a 77-year-old man with hepatitis C virus (HCV)-related cirrhosis is presented. Ultrasonography (US) disclosed a 9 mm hypoechoic lesion in segment seven (S7) of the liver, although computed tomography (CT), magnetic resonance imaging (MRI) and angiography did not reveal any space-occupying lesion. Ultrasound-guided biopsy showed the histological features of well-differentiated HCC. A plain film of the abdomen and CT revealed osteolytic changes in the sacrum and the lumbar vertebra. Ultrasound-guided biopsy of the sacrum revealed well-to-moderately differentiated HCC metastasizing from the liver. Percutaneous ethanol injection therapy (PEIT) effected complete response and completely eliminated the abnormal findings on US. Three months after PEIT, metastasis to the thoracic vertebra was revealed by CT, despite negative α-fetoprotein-mRNA in serum. This is the first report describing a well-differentiated HCC with metastatic potential. Further studies may provide insights into metastasis of well-differentiated HCC. 相似文献
42.
Correlation of human papillomavirus status with apparent diffusion coefficient of diffusion‐weighted MRI in head and neck squamous cell carcinomas 下载免费PDF全文
43.
44.
Jaewoo Park Jinkyeong Park Yoon Suk Lee Kwangrok Jung In Ho Jung Jong-Chan Lee Jin-Hyeok Hwang Jaihwan Kim 《Hepatobiliary & pancreatic diseases international : HBPD INT》2023,22(3):294-301
Background: Pancreatic cysts are common. However, most studies are based on data collected from individual centers. The present study aimed to evaluate the changes of management patterns for pancreatic cystic lesions(PCLs) by analyzing large epidemiologic data. Methods: Between January 2007 and December 2018, information regarding pancreatic cystic lesions was acquired from the nationwide Health Insurance Review and Assessment Service database in Korea. Results: The final number of patients with... 相似文献
45.
Andrade P Visser-Vandewalle V Philippens M Daemen MA Steinbusch HW Buurman WA Hoogland G 《Pain》2011,152(11):2645-2652
Lumbar disc hernia (LDH) is a leading cause of chronic pain in adults. The underlying pathology of chronic pain after discectomy remains unclear. Chronic local inflammation is considered to underlie painful symptomatology. In this context, we investigated tumor necrosis factor (TNF)-α, TNF receptor 1 (TNFR1), and TNF receptor 2 (TNFR2) expression at the time of surgery in LDH patients and correlated it with the severity of postoperative pain. We analyzed protein and mRNA levels from muscle, ligamentum flavum (LF), annulus fibrosus (AF), and nucleus pulposus (NP) in LDH patients and scoliosis patients (SP), who served as controls. Pain assessment with the visual analogue scale (VAS) was performed 1 day before surgery and 6 weeks and 12 months postoperatively. TNF-α protein levels were detected in AF, LF, and NP in all LDH patients, but not in SP. TNF-α mRNA was significantly greater in LDH patients than in SP; ie, 5-fold in AF, 3-fold in NP, and 2-fold in LF. For NP, TNF-α protein levels correlated with VAS scores (r = 0.54 at 6-week and r = 0.65 at 12-month follow-up). Also, TNFR1 protein levels in NP positively correlated with VAS scores (r = 0.75 at 6-week and r = 0.80 at 12-month follow-up). However, TNFR2 protein levels in AF negatively correlated with VAS scores (r = −0.60 at 6 weeks and r = −0.60 at 12 months follow-up). These data indicate that TNF-α levels could determine the clinical outcome in LDH patients after discectomy. Moreover, the opposite correlation of TNF receptors with pain sensation suggests that an unbalanced expression plays a role in the generation of pain. 相似文献
46.
Tim Schakel Johannes M. Hoogduin Chris H.J. Terhaard Marielle E.P. Philippens 《Radiotherapy and oncology》2013
Introduction
The aim of this study is to assess the geometric accuracy of diffusion weighted (DW)-MRI by quantification of geometric distortions in the gross tumor volume (GTV) in head and neck (HN) cancer.Materials & Methods
A retrospective analysis was performed on the data of 23 patients (with 24 lesions). For these patients, magnetic field maps and DW-MRI were acquired. The magnetic field maps were converted to voxel displacement maps. GTV delineations were transferred onto these voxel displacement maps and the voxel shifts in the GTV were analyzed.Results
The median shift was 3.2 mm and the maximal posterior and anterior shifts were up to 15.0 and 26.0 mm respectively. The range of shifts varied from 11.8 to 25.6 mm. The percentage of GTV voxels that showed a shift of at least 6 mm was found to be 23.2%.Conclusions
Current DW-MRI images of HN tumors show severe distortions up to centimeters, which restrict the use of DW-MRI scans for GTV definition in RT treatment planning. 相似文献47.
48.
49.
The possible side effects of therapeutic drugs against organophosphate poisoning were investigated. First, dose-effect curves were obtained with atropine sulphate (AS), P2S, obidoxime, aprophen, N-methylatropine nitrate and HI-6. The first three drugs are currently used in the therapy of organophosphate poisoning, the others are potentially useful candidates. Automated tests measuring open field behavior, motor coordination and shuttlebox performance, as well as neurophysiological techniques such as the quantified EEG (qEEG) and visual evoked responses were used. The sign-free doses of these compounds were determined; it appeared that open field behavior and the qEEG were the most sensitive methods for these drugs. Subsequently, these two methods were used to investigate the effects of the combinations of AS and P2S, AS and obidoxime or AS and HI-6, each compound given in a sign-free dose. Synergistic or additive effects were found with the combination of AS and P2S, which were smaller with the combination of AS and obidoxime and absent with the combination of AS and HI-6. These results indicate that the untimely use (false alarm, panic) of the current drug combinations may cause undesirable side effects. 相似文献
50.
IH Monrad Aas 《Annals of general psychiatry》2011,10(1):2