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141.
Sameena Ahmad M.Sc. Glenn Waller D.Phil. Chrissie Verduyn M.Sc. 《The International journal of eating disorders》1994,15(1):91-97
Asian girls living in the United Kingdom have more unhealthy eating attitudes than Caucasian girls. It has been suggested that this difference may be due to “cultural conflicts,” but that term needs to be operationalized by determining the underlying practical and psychological mechanisms. This study examines the role of perceived parental control as a potential mediating factor between cultural issues and eating psychopathology among schoolgirls. Asian girls had a greater level of bulimic attitudes than Caucasian girls, but a significant part of this difference was due to the Asian girls' greater levels of perceived maternal control. Perceived paternal control also masked an underlying tendency for the Caucasian girls to be more dissatisfied with their bodies than the Asian girls. Further research on ethnic issues and their relationship to clinical interventions is discussed. © 1994 by John Wiley & Sons, Inc. 相似文献
142.
Mechelle R. Bennett Akhil Jain Katalin Kovacs Phil J. Hill Cameron Alexander Frankie J. Rawson 《RSC advances》2021,12(1):451
The use of bacteria as catalysts for radical polymerisations of synthetic monomers has recently been established. However, the role of trans Plasma Membrane Electron Transport (tPMET) in modulating these processes is not well understood. We sort to study this by genetic engineering a part of the tPMET system NapC in E. coli. We show that this engineering altered the rate of extracellular electron transfer coincided with an effect on cell-mediated polymerisation using a model monomer. A plasmid with arabinose inducible PBAD promoters were shown to upregulate NapC protein upon induction at total arabinose concentrations of 0.0018% and 0.18%. These clones (E. coli(IP_0.0018%) and E. coli(IP_0.18%), respectively) were used in iron-mediated atom transfer radical polymerisation (Fe ATRP), affecting the nature of the polymerisation, than cultures containing suppressed or empty plasmids (E. coli(IP_S) and E. coli(E), respectively). These results lead to the hypothesis that EET (Extracellular Electron Transfer) in part modulates cell instructed polymerisations.The use of bacteria as catalysts for radical polymerisations of synthetic monomers has recently been established. 相似文献
143.
Robert Justo Cameron Ward Anthony Slater Julie McEniery Phil Sargent Alan Isles Tom R Karl Nelson Alphonso 《Journal of paediatrics and child health》2020,56(6):833-837
We describe a complex change process for the paediatric cardiac service in Queensland that involved transitioning the service out of an essentially adult hospital into one of two children's hospitals in Brisbane. This initial step was complex as the governance was changed from Queensland Health to Mater Health, an independent faith‐based organisation who became the new employer. Six years later, the service was again transitioned; this time to the newly constructed Queensland Children's Hospital, with a Hospital and Health Services Board as the employer under the aegis of Queensland Health. This was a complex journey. As with all change processes there was resistance to change on the part of some individuals. Five years on from the second major change, the service is settled, has an excellent workplace culture, has excellent clinical outcomes and has become research intensive. 相似文献
144.
145.
Umut Disel Russell Madison Kumar Abhishek Jon H. Chung Sally E. Trabucco Asli O. Matos Garrett M. Frampton Lee A. Albacker Venkataprasanth Reddy Nuri Karadurmus Adam Benson Jennifer Webster Semra Paydas Ruben Cabanillas Chaitali Nangia M.A. Ozturk Sherri Z. Millis Sumanta K. Pal Breelyn Wilky Ethan S. Sokol Laurie M. Gay Salil Soman Shridar Ganesan Katherine Janeway Phil J. Stephens Viola W. Zhu Sai-Hong Ignatius Ou Christine M. Lovly Mrinal Gounder Alexa B. Schrock Jeffrey S. Ross Vincent A. Miller Samuel J. Klempner Siraj M. Ali 《The oncologist》2020,25(1):e39-e47
146.
Michelle Harvie Mary Pegington Sacha J. Howell Nigel Bundred Phil Foden Judith Adams Lee Graves Alastair Greystoke Mark P. Mattson Roy G. Cutler Julie Williamson Karen Livingstone Debbie McMullen Katharine Sellers Cheryl Lombardelli Grace Cooper Sarah McDiarmid Anthony Howell 《British journal of cancer》2022,126(8):1157
Background Excess adiposity at diagnosis and weight gain during chemotherapy is associated with tumour recurrence and chemotherapy toxicity. We assessed the efficacy of intermittent energy restriction (IER) vs continuous energy restriction (CER) for weight control and toxicity reduction during chemotherapy.Methods One hundred and seventy-two women were randomised to follow IER or CER throughout adjuvant/neoadjuvant chemotherapy. Primary endpoints were weight and body fat change. Secondary endpoints included chemotherapy toxicity, cardiovascular risk markers, and correlative markers of metabolism, inflammation and oxidative stress.Results Primary analyses showed non-significant reductions in weight (−1.1 (−2.4 to +0.2) kg, p = 0.11) and body fat (−1.0 (−2.1 to +0.1) kg, p = 0.086) in IER compared with CER. Predefined secondary analyses adjusted for body water showed significantly greater reductions in weight (−1.4 (−2.5 to −0.2) kg, p = 0.024) and body fat (−1.1 (−2.1 to −0.2) kg, p = 0.046) in IER compared with CER. Incidence of grade 3/4 toxicities were comparable overall (IER 31.0 vs CER 36.5%, p = 0.45) with a trend to fewer grade 3/4 toxicities with IER (18%) vs CER (31%) during cycles 4–6 of primarily taxane therapy (p = 0.063).Conclusions IER is feasible during chemotherapy. The potential efficacy for weight control and reducing toxicity needs to be tested in future larger trials.Clinical trial registration ISRCTN04156504.Subject terms: Randomized controlled trials, Breast cancer, Nutrition, Weight management, Breast cancer 相似文献
147.
148.
Iosif Xenogiannis Dimitri Karmpaliotis Khaldoon Alaswad Farouc A. Jaffer Robert W. Yeh Mitul Patel Ehtisham Mahmud James W. Choi M. Nicholas Burke Anthony H. Doing Phil Dattilo Catalin Toma A.J. Conrad Smith Barry Uretsky Oleg Krestyaninov Dmitrii Khelimskii Elizabeth Holper Srinivas Potluri Emmanouil S. Brilakis 《The American journal of cardiology》2019,123(9):1422-1428
149.
Jennie E. Murray Louise S. Bicknell Gökhan Yigit Angela L. Duker Margriet van Kogelenberg Sara Haghayegh Dagmar Wieczorek Hülya Kayserili Michael H. Albert Carol A. Wise January Brandon Tjitske Kleefstra Adilia Warris Michiel van der Flier J. Steven Bamforth Kurston Doonanco Lesley Adès Alan Ma Michael Field Diana Johnson Fiona Shackley Helen Firth C. Geoffrey Woods Peter Nürnberg Richard A. Gatti Matthew Hurles Michael B. Bober Bernd Wollnik Andrew P. Jackson 《Human mutation》2014,35(1):76-85
Ligase IV syndrome is a rare differential diagnosis for Nijmegen breakage syndrome owing to a shared predisposition to lympho‐reticular malignancies, significant microcephaly, and radiation hypersensitivity. Only 16 cases with mutations in LIG4 have been described to date with phenotypes varying from malignancy in developmentally normal individuals, to severe combined immunodeficiency and early mortality. Here, we report the identification of biallelic truncating LIG4 mutations in 11 patients with microcephalic primordial dwarfism presenting with restricted prenatal growth and extreme postnatal global growth failure (average OFC ?10.1 s.d., height ?5.1 s.d.). Subsequently, most patients developed thrombocytopenia and leucopenia later in childhood and many were found to have previously unrecognized immunodeficiency following molecular diagnosis. None have yet developed malignancy, though all patients tested had cellular radiosensitivity. A genotype–phenotype correlation was also noted with position of truncating mutations corresponding to disease severity. This work extends the phenotypic spectrum associated with LIG4 mutations, establishing that extreme growth retardation with microcephaly is a common presentation of bilallelic truncating mutations. Such growth failure is therefore sufficient to consider a diagnosis of LIG4 deficiency and early recognition of such cases is important as bone marrow failure, immunodeficiency, and sometimes malignancy are long term sequelae of this disorder. 相似文献
150.