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排序方式: 共有190条查询结果,搜索用时 31 毫秒
61.
62.
C Mostardini VC d'Agostino DE Dugoni & R Cerbo 《Cephalalgia : an international journal of headache》2009,29(12):1326-1330
Headache symptoms account for 1–3% of admissions to an emergency department (ED). Most patients affected by a primary headache (PH) have migraine, although they are often misdiagnosed as 'headache not otherwise specified'. We investigated the possibility of using ID-Migraine (ID-M) to improve migraine recognition in the ED setting. We planned a pilot study involving ED out-patients with a diagnosis of PH. Diagnoses of a blinded headache expert were subsequently matched with the ID-M results. We tested ID-M on 230 patients (199 PH, 31 secondary headaches). Considering only PH, ID-M exhibited a sensitivity of 0.94 and specificity of 0.83 with a positive predictive value (PPV) of 0.99. The ID-M is a simple migraine screener with high sensitivity, high specificity and high PPV, even in an ED-derived population. Methodical use of this tool in an ED setting may, once a secondary headache has been excluded, lead to rapid diagnosis of migraine. 相似文献
63.
64.
RAJVIR BHALWAR N K DEBATA UK B CHITNIS AL SHARMA VC OHRI VW TILAK 《Medical Journal Armed Forces India》1999,55(1):32-34
A cross-sectional epidemiological study was undertaken on a randomly selected sample of 308 food handlers working in different eating establishments of Indian Armed Forces in Pune. These included 101 Service personnel and 207 civilians. Stool samples were analysed for enteropathogens and epidemiological assessment of gastrointestinal disease occurrence in the military units of these food handlers was undertaken. The study revealed that 4 of the subjects were carriers of salmonella typhimurium, thus giving the prevalence as 1.3% (95% confidence interval 0.2% to 2.56%). No other enteropathogen except salmonella typhimurium was isolated. The positive carriers showed a typical “spatial - clustering” in that they were working in two geographically contiguous medical units.KEY WORDS: Carriers, Food-handlers, Salmonella typhimurium 相似文献
65.
S M GARG SKP MATWANKAR RAJVIR BHALWAR NK DEBATA VC OHRI DK SAKSENA 《Medical Journal Armed Forces India》1998,54(3):188-190
A prospective study on the growth of bacteria on certain commonly used anaesthetic equipment was undertaken in a large teaching hospital with a view to assess the effectiveness of disinfection/sterilization procedures. Samples for microbiological assessment were drawn by the worker using standardised procedures and tested in the laboratory by a microbiologist, blinded to the type of sample. Criteria for growth positivity was taken as > 25 colony forming units. A total of 90 observations were taken. 30 each for ’before use’, ’after use’ and ’after disinfection’. Overall 54.6% of the equipment showed growth “before use” with maximum growth being seen in Suction catheters (66.6%) and Guedal airways (60.0%). On the other hand, the proportion of equipment showing growth “after use” was quite high (84.6%), with suction catheters and endotracheal tubes showing 90.0% growth each. There was significant difference as regards “before” and “after” use growth on Endotracheal tubes, Guedel airways and Face masks (p < 0.05). Analysis of growth “after” disinfection” revealed that the probability of growth remains as high as 70% in suction catheters (95% CI=54% to 86%) and 60% in laryngoscopes (95% CI=43% to 78%). The study revealed gross inadequacies in methods of disinfection being followed at present.KEY WORDS: Anaesthetic equipment, Disinfection 相似文献
66.
This article reviews Interleukin (IL) IL-12 a recently described cytokine secreted by monocyte/macrophages and its interaction with T cells. IL 12 is important in the immune response by providing a link between natural resistance mediated by phagocytic cells and NK cells and adaptive immunity mediated by T4, T8 and B cells. The article also evaluates the effect of IL12 in the evolution of T helper cell subsets, its action as a bridge between innate immunity and acquired immunity and the important role it plays in modulating the cellular and humoral immune response mechanisms. Its possible role as an immunomodulator of disease is postulated.KEY WORDS: CIMI, Immunomodulation, IL-12, T cells 相似文献
67.
Wayne S; Der Kaloustian VM; Schloss M; Polomeno R; Scott DA; Hejtmancik JF; Sheffield VC; Smith RJ 《Human molecular genetics》1996,5(10):1689-1692
The Usher syndromes (USH) are a group of autosomal recessive diseases
characterized by progressive pigmentary retinopathy and sensorineural
hearing loss. Five USH genes have been mapped and at least one additional
gene is known to exist. By homozygosity mapping in a consanguineous family,
a sixth USH gene has been localized. Clinical findings in the four affected
children are consistent with established diagnostic criteria for Ush1.
Linkage to known USH loci was excluded, and using two genomic DNA pools,
one from the affected children and the other from the parents, 161
polymorphic markers evenly spaced across the autosomal human genome were
screened. The location of the Ush1D gene was defined by the only region
showing homozygosity by descent in the affected siblings, a 15 cM interval
on chromosome 10q bounded by D10S529 and D10S573.
相似文献
68.
Autosomal dominant Charcot-Marie-Tooth axonal neuropathy mapped on chromosome 7p (CMT2D) 总被引:9,自引:0,他引:9
Ionasescu V; Searby C; Sheffield VC; Roklina T; Nishimura D; Ionasescu R 《Human molecular genetics》1996,5(9):1373-1375
Clinical, electrophysiological and genetic linkage studies were performed
on a large autosomal dominant family with Charcot-Marie-Tooth axonal
neuropathy type 2 (CMT2) with 38 members of which 14 were affected. Onset
of the disease was between 16 and 30 years of age with weakness and atrophy
of the hands more severe than of the feet with slow progressive course in
12 patients. Deep tendon reflexes were absent in the upper extremities and
decreased in the lower extremities. There was distal hypesthesia for touch,
proprioception and vibration sense for the hands more than for the feet.
Motor nerve conduction velocities showed normal values (48-53 M/s) with
normal latencies (2-3 msec) and electromyography revealed signs of
denervation. Genetic linkage analysis used 167 short tandem repeat markers
(STRPs) spaced throughout the 22 autosomes. Linkage to the short arm of
chromosome 7 at 7p14 was found using the marker D7S435 (Z = 4.83 at theta =
0). Flanking markers were D7S1808 and D7S1806 and the genetic distance
between them was 6.8 cM. The multipoint linkage analysis gave a peek
multipoint lod score of 6.89 between the markers D7S1808 and D7S435.
Linkage analysis showed significantly negative lod scores (with values less
than -2) with markers of chromosomes 1 and 3 where CMT axonal forms have
been previously mapped. PFGE analysis indicated the absence of the CMT1A
duplication. Our findings are consistent with a new genetic type of axonal
CMT neuropathy designated by us as CMT2D. Potential candidate genes are
multiple T-cell gamma receptor genes which map to the same cytogenetic
interval as CMT2D neuropathy.
相似文献
69.
Ana VC Dutra Hsiu-Fen Lin Suh-Hang H Juo Harvey Mohrenweiser Souvik Sen Raji P Grewal 《BMC medical genetics》2006,7(1):78
Background
Although there have been studies of the genetic risk factors in the development of stroke, there have been few investigations of role of genes in the cerebral response to ischemia. The brain responds to ischemia in a series of reactions that ultimately influence the volume of a stroke that, in general, correlates with disability. We hypothesize that polymorphisms in genes encoding proteins involved in these reactions could act as modifiers of this response and impact stroke volume. One of the pathways participating in the cerebral ischemic response involves reactive oxygen species which can cause oxidative damage to nucleic acids. DNA repair mechanisms are in place to protect against such damage and imply a role for DNA repair genes in the response of the brain to ischemia and are potential candidate genes for further investigation. 相似文献70.