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631.
632.
Pavlidis Pavlos Nikolaidis Vasilios Anogeianaki Antonia Koutsonikolas Dimitrios Kekes Georgios Anogianakis Georgios 《BMC ear, nose, and throat disorders》2009,9(1):1-7
Background
Nasopharyngeal non-Hodgkin lymphomas (NNHL) are extremely rare. In this study, we will report the progress achieved in the management of this disease in our institute.Methods
We retrospectively reviewed the records of 26 patients having primary NNHL who were managed between January 1997 and December 2008, to evaluate and compare their clinical characteristics and treatment outcome. Clinical variables, including age, sex, stage, and treatment modality, were assessed. Disease free survival and overall survival were measured. Survival curves were constructed using the KaplanMeier method. The log-rank test was used to compare them.Results
Median age of our patients was 52.7 years. Nasal obstruction, nasal discharge and epistaxis were the frequent symptoms in NNHL patients. Histology of NNHL were mainly large B-cell and follicular lymphoma. Four patients (15.4%) were at stage I, 15 (57.6%) at stage II, and 7 (27%) were at stage III/IV. The patients were treated with chemotherapy alone (27%) or chemotherapy plus radiotherapy (73%). At early stage (stage I/II), the patients were managed with chemo-radiotherapy. When the whole treatment was completed, 18 patients (69.2%) achieved complete response and remained disease free. After 25.9 months median follow-up, overall survival at 1 year was 87% and disease free survival at 1 year was 71%. The difference in term of overall and disease free survival between stage I, II, III and IV was significant (Log rank test: p = 0.02 for overall survival and p = 0.01 for disease free survival).Conclusion
From our study, we conclude that histological characteristics, principle of treatment and outcome of primary NNHL patients are particular and more studies have to be directed. 相似文献633.
Pavlos Msaouel Ianko D Iankov Cory Allen Ileana Aderca Mark J Federspiel Donald J Tindall John C Morris Michael Koutsilieris Stephen J Russell Evanthia Galanis 《Molecular therapy》2009,17(12):2041-2048
Prostate cancer cells overexpress the measles virus (MV) receptor CD46. Herein, we evaluated the antitumor activity of an oncolytic derivative of the MV Edmonston (MV-Edm) vaccine strain engineered to express the human sodium iodide symporter (NIS; MV-NIS virus). MV-NIS showed significant cytopathic effect (CPE) against prostate cancer cell lines in vitro. Infected cells effectively concentrated radioiodide isotopes as measured in vitro by Iodide-125 (125I) uptake assays. Virus localization and spread in vivo could be effectively followed by imaging of 123I uptake. In vivo administration of MV-NIS either locally or systemically (total dose of 9 × 106 TCID50) resulted in significant tumor regression (P < 0.05) and prolongation of survival (P < 0.01). Administration of 131I further enhanced the antitumor effect of MV-NIS virotherapy (P < 0.05). In conclusion, MV-NIS is an oncolytic vector with significant antitumor activity against prostate cancer, which can be further enhanced by 131I administration. The NIS transgene allows viral localization and monitoring by noninvasive imaging which can facilitate dose optimization in a clinical setting. 相似文献
634.
Jerde TA Lewis SM Goerke U Gourtzelidis P Tzagarakis C Lynch J Moeller S Van de Moortele PF Adriany G Trangle J Uğurbil K Georgopoulos AP 《Experimental brain research. Experimentelle Hirnforschung. Expérimentation cérébrale》2008,187(4):551-561
We used ultra-high field (7 T) fMRI and parallel imaging to scan the superior parietal lobule (SPL) of human subjects as they
mentally traversed a maze path in one of four directions (up, down, left, right). A counterbalanced design for maze presentation
and a quasi-isotropic voxel (1.46 × 1.46 × 2 mm thick) collection were implemented. Fifty-one percent of single voxels in
the SPL were tuned to the direction of the maze path. Tuned voxels were distributed throughout the SPL, bilaterally. A nearest
neighbor analysis revealed a “honeycomb” arrangement such that voxels tuned to a particular direction tended to occur in clusters.
Three-dimensional (3D) directional clusters were identified in SPL as oriented centroids traversing the cortical depth. There
were 13 same-direction clusters per hemisphere containing 22 voxels per cluster, on the average; the mean nearest-neighbor,
same-direction intercluster distance was 9.4 mm. These results provide a much finer detail of the directional tuning in SPL,
as compared to those obtained previously at 4 T (Gourtzelidis et al. Exp Brain Res 165:273–282, 2005). The more accurate estimates of quantitative clustering parameters in 3D brain space in this study were made possible by
the higher signal-to-noise and contrast-to-noise ratios afforded by the higher magnetic field of 7 T as well as the quasi-isotropic
design of voxel data collection. 相似文献
635.
636.
Anna Paschali Lambros Messinis Odysseas Kargiotis Velissarios Lakiotis Zinovia Kefalopoulou Costantinos Constantoyannis Panagiotis Papathanasopoulos Pavlos Vassilakos 《European journal of nuclear medicine and molecular imaging》2010,37(6):1128-1140
Purpose
The present study investigated differences and associations between cortical perfusion, nigrostriatal dopamine pathway and neuropsychological functions in different stages of Parkinson’s disease (PD). 相似文献637.
Georgiou I Syrrou M Pardalidis N Karakitsios K Mantzavinos T Giotitsas N Loutradis D Dimitriadis F Saito M Miyagawa I Tzoumis P Sylakos A Kanakas N Moustakareas T Baltogiannis D Touloupides S Giannakis D Fatouros M Sofikitis N 《Asian journal of andrology》2006,8(6):643-673
Pregnancies achieved by assisted reproduction technologies,particularly by intracytoplasmic sperm injection(ICSI)procedures,are susceptible to genetic risks inherent to the male population treated with ICSI and additionalrisks inherent to this innovative procedure.The documented,as well as the theoretical,risks are discussed in thepresent review study.These risks mainly represent thatconsequences of the genetic abnormalities underlying malesubfertility(or infertility)and might become stimulators for the development of novel approaches and applications inthe treatment of infertility.In addition,risks with a polygenic background appearing at birth as congenital anomaliesand other theoretical or stochastic risks are discussed.Recent data suggest that assisted reproductive technologymight also affect epigenetic characteristics of the male gamete,the female gamete,or might have an impact on earlyembryogenesis.It might be also associated with an increased risk for genomic imprinting abnormalities.(Asian JAndrol 2006 Nov;8:643-673) 相似文献
638.
Wong J Papadopoulos P Werling J Rebbeck C Doty M Kipp J Konkel J Neuberger D 《PDA journal of pharmaceutical science and technology / PDA》2006,60(5):302-313
The purpose of this study is to assess the impact of real refractive indices, using different itraconazole suspensions, on the associated particle size distributions. Instrumental particle size measurement remains the practical option for determining the particle size distribution of a suspension. In this study, the suspension particle size distribution was measured by static light scattering, which requires knowledge of both the real and imaginary components of the complete refractive index. The real refractive indices of micronized itraconazole raw material, as well as vacuum-dried itraconazole suspension samples obtained from different formulations, polymorphs, manufacturing methods and particle size distributions, were determined using the Becke line method. Identical samples were analyzed by two contract laboratories in order to assess consistency. For the static light scattering equipment used in this study, the complete relative refractive index (RRI = n(particte) / n(dispersant) - ik) input required for software calculation is denoted by a refractive index kernel (RRI input) comprising a relative real component and an imaginary component. The reported real refractive indices for the itraconazole raw material as well as vacuum dried itraconazole suspension samples were different, ranging from 1.608 to 1.65 (selected kernel range of 120A010I to 124A010I). The imaginary component of itraconazole suspension was determined in a previous study to be 010I. The average real refractive index was calculated to be 1.62 (122A010I). The particle size distributions obtained using 120A010I and 124A010I were in good agreement with one generated using 122A010I. Therefore, itraconazole suspensions that were produced using different manufacturing methods/formulations or exhibited different particle size distributions/polymorphic forms may use 122A010I in determining particle size distribution. The particle size distributions determined using RRI input outside the range of 120A010I to 124A010I may not be reliable. However, it is recommended that similar investigations be conducted for other drug suspensions on a case-by-case basis. 相似文献
639.
Myrianthefs P Boutzouka E Venetsanou K Papalois A Kouloukousa M Kittas C Baltopoulos G 《Vascular pharmacology》2006,44(5):283-289
The purpose of the study was to investigate the effect of different ventilatory strategies on local and systemic cytokine production in swine with intact lungs in vivo after 4 h of mechanical ventilation. Twenty-five swine were anesthetized and then randomized into five groups (n = 5): (1) low tidal volume zero PEEP (LVZP); (2) medium tidal volume zero PEEP (MVZP); (3) high tidal volume zero PEEP (HVZP); (4) low tidal volume PEEP (LVP); (4) high tidal volume PEEP (HVP). Respiratory rate was adjusted to maintain normocapnia and fraction of inspired oxygen (FiO2) was 1.0. TNF-alpha and IL-10 were measured in BALF and serum at baseline, 2 h, and 4 h of MV. One animal in LVZP (2 h) and two in HVP (3 h) group died before the end of the experiment. TNF-alpha level in BALF was significantly higher in LVZP and LVP at 4 h compared to baseline and the other groups. IL-10 level in BALF was significantly higher in LVP at 4h compared to baseline and the other groups. There was a statistically significant increase in serum TNF-alpha levels at 4 h in LVP group compared to baseline and the other groups at 4 h. There was statistically significant increase in serum IL-10 levels in HVZP and LVP groups at 2 and 4 h which was significantly higher compared to the other groups at 4 h. Our results show that a) low volume MV may induce local and systemic pro- and anti-inflammatory cytokine increase b) in the presence of pro-inflammatory cytokine response there is also an anti-inflammatory response in the same compartment (lungs, circulation). c) There maybe loss of alveolar-to-systemic cytokine compartmentalization. 相似文献
640.
Cutaneous T cell lymphomas (CTCLs) are a heterogenous group of lymphoproliferative disorders caused by clonally-derived, skin-invasive T cells. A variety of skin-directed and systemic therapies are available to treat mycosis fungoides/Sézary syndrome (MF/SS), the therapeutic choices of which are guided by the stage of disease. A 29-year-old man presented at our clinic with pruritic, erythematous macules located on the sternum and the lower back. Histological findings and immunohistochemistry studies showed patch stage MF. The patient was treated with tacrolimus ointment 0.1% twice daily for one month, achieving complete remission. Three months after the first episode a relapse was successfully treated with the same therapeutic regimen. Tacrolimus is an immunomodulatory macrolide that reduces the stimulatory capacity toward T cells and is therefore worth investigating as a treatment of CTCL. Topical tacrolimus has been related to an unknown effect with the risk for secondary malignancies including CTCL. Also, black box warnings have been proposed by the FDA for the topical calcineurin inhibitors. Nevertheless, our results in the treatment of early stage MF are in agreement with other unpublished data that have observed its efficacy. To our knowledge, there is no other case of patch type mycosis fungoides treated with tacrolimus ointment 0.1% in the medical literature. 相似文献