全文获取类型
收费全文 | 237篇 |
免费 | 12篇 |
国内免费 | 18篇 |
专业分类
耳鼻咽喉 | 2篇 |
儿科学 | 12篇 |
妇产科学 | 1篇 |
基础医学 | 29篇 |
口腔科学 | 3篇 |
临床医学 | 45篇 |
内科学 | 68篇 |
皮肤病学 | 1篇 |
神经病学 | 6篇 |
特种医学 | 34篇 |
外科学 | 20篇 |
综合类 | 15篇 |
预防医学 | 7篇 |
药学 | 13篇 |
肿瘤学 | 11篇 |
出版年
2022年 | 2篇 |
2021年 | 3篇 |
2019年 | 2篇 |
2018年 | 2篇 |
2017年 | 3篇 |
2016年 | 3篇 |
2015年 | 4篇 |
2014年 | 6篇 |
2013年 | 5篇 |
2012年 | 1篇 |
2011年 | 2篇 |
2010年 | 7篇 |
2009年 | 11篇 |
2008年 | 5篇 |
2007年 | 19篇 |
2006年 | 6篇 |
2005年 | 2篇 |
2004年 | 4篇 |
2003年 | 5篇 |
2002年 | 4篇 |
2001年 | 6篇 |
2000年 | 8篇 |
1999年 | 5篇 |
1998年 | 17篇 |
1997年 | 16篇 |
1996年 | 17篇 |
1995年 | 10篇 |
1994年 | 19篇 |
1993年 | 4篇 |
1992年 | 2篇 |
1991年 | 4篇 |
1990年 | 8篇 |
1989年 | 15篇 |
1988年 | 7篇 |
1987年 | 4篇 |
1986年 | 4篇 |
1985年 | 5篇 |
1984年 | 3篇 |
1983年 | 3篇 |
1982年 | 1篇 |
1981年 | 5篇 |
1980年 | 5篇 |
1979年 | 1篇 |
1978年 | 1篇 |
1977年 | 1篇 |
排序方式: 共有267条查询结果,搜索用时 15 毫秒
131.
A randomized controlled trial of single‐class maintenance therapy with abacavir/lamivudine/zidovudine after standard triple antiretroviral induction therapy: final 96‐week results from the FREE study 下载免费PDF全文
132.
Predictive factors for acute graft-versus-host disease in patients transplanted with HLA-identical bone marrow 总被引:3,自引:1,他引:3
Bross DS; Tutschka PJ; Farmer ER; Beschorner WE; Braine HG; Mellits ED; Bias WB; Santos GW 《Blood》1984,63(6):1265-1270
To identify predictive parameters for incidence and severity of acute graft-versus-host disease (GVHD), 136 patients, transplanted with histocompatible marrow as therapy for aplastic anemia and hematologic malignancies, were examined using univariate and multivariate analyses. The risk of GVHD increased in patients with acute lymphocytic leukemia (p less than 0.05), in sex-mismatched donor-recipient pairs (p less than 0.01), and in patients older than 23.7 yr (p less than 0.05). No other commonly observed factors appeared to have any relationship to GVHD except the presence of certain alleles. The presence of a Cw4 allele or of the Bw21 specificities B49 and B50 were associated with significantly increased risks of GVHD (p less than 0.05), whereas the presence of Aw19 (or the related specificities A29, Aw30, Aw31 , Aw32, Aw33 ) was associated with a significantly decreased risk (p less than 0.01). Using these factors, a regression equation can be constructed that estimates the risk of a given patient to develop clinically significant acute GVHD. 相似文献
133.
Migration-inhibitory factor (MIF) is a lymphokine that acts to localize mononuclear phagocytes (monocytes and macrophages) and perhaps to activate them. Mo cells are a human T cell leukemia virus II-infected T cell line previously shown to secrete large quantities of MIF upon stimulation with phytohemagglutinin and phorbol myristate acetate. MIF was purified from Mo cell-conditioned medium by gel filtration, phenyl- Sepharose affinity chromatography, isoelectrofocusing, and reverse- phase high-performance liquid chromatography (RP-HPLC). Overall purification was 6,000-fold. The purified MIF fraction was found to display potent colony-stimulating factor (CSF) activity when assayed on human bone marrow cells. The double peak of MIF activity as shown by C 18-RP-HPLC coincided with the double peak of CSF activity. A monoclonal antibody selected for its anti-MIF activity absorbed both the CSF and the MIF activity. These findings indicate that MIF and CSF are either identical molecules or closely related molecules with common structural elements. 相似文献
134.
135.
Paschalis Tossios Jochen Müller-Ehmsen Matthias Schmidt Christof Scheid Nermin Ünal Detlef Moka Robert HG Schwinger Uwe Mehlhorn 《BMC medical imaging》2006,6(1):1-9
Background
Subtraction of Dynamic Contrast-Enhanced 3D Magnetic Resonance (DCE-MR) volumes can result in images that depict and accurately characterize a variety of liver lesions. However, the diagnostic utility of subtraction images depends on the extent of co-registration between non-enhanced and enhanced volumes. Movement of liver structures during acquisition must be corrected prior to subtraction. Currently available methods are computer intensive. We report a new method for the dynamic subtraction of MR liver images that does not require excessive computer time. 相似文献136.
137.
138.
Verhage HG; Fazleabas AT; Mavrogianis PA; O'Day-Bowman MB; Donnelly KM; Arias EB; Jaffe RC 《Human reproduction update》1997,3(6):541-552
The baboon oviductal epithelium differentiates into a tall columnarepithelium consisting of ciliated and secretory cells duringthe follicular phase of the menstrual cycle in response to risingoestradiol levels. The apical tips of these secretory cellsare filled with membrane-bound secretory granules. During theluteal phase when progesterone levels are elevated, the epitheliumregresses and deciliation occurs. Analysis of secretory proteinsobtained from explant culture media by SDS-PAGE followed byfluorography or Western Blots has revealed that the baboon oviductsynthesizes and secretes a high molecular weight glycoproteinduring the follicular phase of the cycle. Immunocytochemistrydemonstrated that the oviductal glycoprotein is localized tothe secretory granules of epithelial secretory cells, is oviductspecific, and that following secretion the oviductal glycoproteinbinds to the zona pellucida and periviteline space of ovulatedoocytes and embryos within the oviduct. Similar proteins havebeen characterized in other mammalian species. cDNA data showthat the complete coding sequence is 2228 bp for a protein of623 amino acids. A Genbank search showed that baboon oviductalglycoprotein has high homology to other oviductal glycoproteinsequences at both the nucleotide and amino acid levels. Studiesconducted to date probing the biological function of oviductalglycoprotein indicate that this protein plays a role in prefertilizationreproductive events (sperm capacitation; sperm-zona binding;zona penetration). Additional experiments are needed to reveala specific function and mechanism for this molecule. 相似文献
139.
140.