全文获取类型
收费全文 | 596篇 |
免费 | 49篇 |
国内免费 | 2篇 |
专业分类
耳鼻咽喉 | 1篇 |
儿科学 | 31篇 |
妇产科学 | 10篇 |
基础医学 | 59篇 |
口腔科学 | 15篇 |
临床医学 | 75篇 |
内科学 | 108篇 |
皮肤病学 | 24篇 |
神经病学 | 31篇 |
特种医学 | 14篇 |
外科学 | 52篇 |
综合类 | 3篇 |
预防医学 | 61篇 |
眼科学 | 22篇 |
药学 | 95篇 |
中国医学 | 5篇 |
肿瘤学 | 41篇 |
出版年
2024年 | 3篇 |
2023年 | 10篇 |
2022年 | 29篇 |
2021年 | 51篇 |
2020年 | 20篇 |
2019年 | 39篇 |
2018年 | 34篇 |
2017年 | 32篇 |
2016年 | 28篇 |
2015年 | 25篇 |
2014年 | 52篇 |
2013年 | 48篇 |
2012年 | 54篇 |
2011年 | 54篇 |
2010年 | 31篇 |
2009年 | 25篇 |
2008年 | 26篇 |
2007年 | 25篇 |
2006年 | 25篇 |
2005年 | 17篇 |
2004年 | 5篇 |
2003年 | 9篇 |
2002年 | 3篇 |
1998年 | 1篇 |
1996年 | 1篇 |
排序方式: 共有647条查询结果,搜索用时 15 毫秒
611.
Parisa Amiri Sara Jalali-Farahani Maryam Zarkesh Maryam Barzin Robabeh Kaviani Sajad Ahmadizad 《Quality of life research》2014,23(6):1797-1802
Purpose
The aim of this study was to determine the reliability and validity of the Iranian version of the Quantification de l’Activite Physique en Altitude Chez les Enfants (QAPACE) in adolescents.Methods
After linguistic validation, the Iranian version of the QAPACE was completed by 359 (52.4 % girls) schoolchildren, aged 15–18 years. Test–retest reliability of the questionnaire was determined by intraclass correlation coefficients (ICCs). For validation purposes, two methods were used for (1) the correlation between VO2peak and the DEE and (2) known-group validity, which was examined by comparing the normal weight adolescents and those who were overweight/obese.Results
ICCs for test–retest ranged from 0.79 to 0.98. The mean scores in test–retest surveys for total score and all of the subscores were significant (p < 0.05). Sex-specific analysis showed a significant correlation between VO2peak and DEE over 12-month, school, and vacation periods in girls (p < 0.05). The mean values for all activities except for transportation, other activities in school, personal artistic activities, sport competition, and home activities were significantly lower in overweight/obese group than normal group.Conclusion
Our results support the initial reliability and validity of the Iranian version of QAPACE as a daily physical activity measure in adolescents. 相似文献612.
Parisa Sarkhail Marjan Nikan Pantea Sarkheil Ahmad R Gohari Yousef Ajani Rohollah Hosseini Abbass Hadjiakhoondi Soodabeh Saeidnia 《Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences》2014,22(1):32
Background
The genus Phlomis (Lamiaceae) is introduced by its valuable medicinal species, of which 17 species are growing wildly and ten of them are exclusively endemic of Iran. The main phytochemical characteristic of this genus is presence of iridoid glycosides including ipolamide, auroside, lamiide and also phenylethanoids such as verbascoside (acetoside) found in Lamiales order.Due to the broad range of biological and pharmacological activities of verbascoside and lack of any report on quantification of this compound within Iranian species of Phlomis, we conducted a research to achieve two main goals, finding a genetic biodiversity by RAPD (Randomly Amplified Polymorphic DNA), as well as detecting and quantifying verbascoside in nine species of Phlomis growing wildly in Iran.Results
The results showed that various samples of P.olivieri possess different genetic distances from each other. Also, various species of P.olivieri display close relationships to P.anisodonta and P. persica. Phytoanalysis of Phlomis species by means of TLC scanner using verbascoside as a phytochemical marker showed that the highest concentration of verbascoside was found in P. anisodonta, however, P. bruguieri and P. olivieri (from Mazandaran) were in the second and third places. Interestingly, the lowest concentration of verbascoside was detected in P. olivieri (from Azerbayjan), exhibiting the effect of various growing areas and conditions on the measured levels of this compound.Conclusions
verbascoside can be found in various species of Iranian Phlomis, of which P. anisodonta, P. bruguieri and P. olivieri might be the best choices. In addition, although the concentration of verbascoside in these plants may be affected by the growing areas and conditions, there are a good agreement between genetic relations and verbascoside levels. 相似文献613.
Vivien Tong David K. Raynor Parisa Aslani 《International journal of clinical pharmacy》2014,36(5):865-872
Background Over-the-counter medicines must be supplied with appropriate, user-friendly medicine information to satisfactorily support consumer self-management and safe use. Product labels and written medicine information leaflets are highly accessible over-the-counter medicine information sources for consumers. Factors such as comprehensibility and design underpin the usefulness of over-the-counter labels and leaflets and should be further examined to better inform future optimisation strategies. Aim of the review To undertake an in-depth exploration of studies that have evaluated design and/or comprehensibility of over-the-counter labels and written medicine information leaflets Methods Database searches were performed using Medline, Embase, International Pharmaceutical Abstracts and PubMed. Studies exploring over-the-counter medicine label and/or leaflet comprehensibility and/or design were identified. Additional author and reference list searches were performed to identify studies which met the inclusion criteria and key terms. Results A total of 35 studies were included in the review, which explored OTC medicine information design and/or comprehensibility via researcher evaluation alone (n = 8) or with consumers (n = 27). Researcher-determined over-the-counter written medicine information leaflet readability (n = 4) has highlighted suboptimal readability, with few studies evaluating over-the-counter leaflet performance using the gold standard method of ‘user testing’ with consumers (n = 2). Variable over-the-counter label comprehensibility was identified in consumer studies, ranging from satisfactory understanding to considerable misunderstanding. The review findings indicate that consumer outcomes were influenced by information design, where implementation of good design principles generally improved over-the-counter label and leaflet performance. Significant diversity existed in study design aspects such as sampling frames, sample sizes and tools used to evaluate over-the-counter medicine information, which hindered the ability to adequately compare various study aspects and findings. Conclusion A wide spectrum of consumer understanding of over-the-counter medicine labels is evident in the literature, with limited studies examining over-the-counter written medicine information leaflet comprehensibility with consumers. The application of good information design principles in over-the-counter labels and leaflets contribute to improved performance. Well-designed consumer studies are needed to ascertain and optimise over-the-counter label and leaflet performance. 相似文献
614.
Parisa Aliahmadipoor Dadkhoda Ghazanfari Rasoul Jamshidi Gohari Mohammad Reza Akhgar 《RSC advances》2020,10(41):24653
In this study, novel electrospun nanofibers (NFs) composed of organic polyvinylidine fluoride (PVDF) and inorganic Fe–Mn binary oxide (FMBO) nanoparticles were fabricated using an electrospinning technique for adsorptive decontamination of As(v) from polluted water. The NFs were prepared with doped solutions consisting of different weight ratios of PVDF/FMBO, in a NF matrix, ranging from 0 to 0.5. SEM, XRD, FTIR and TEM then characterized the NFs and FMBO particles. The XRD analysis indicated successful impregnation of FMBO nanoparticles in the NF matrix of the NFs investigated. An As(v) adsorption capacity as high as around 21.32 mg g−1 was obtained using the NF containing the highest amount of FMBO nanoparticles (designated as PVDF/FMBO 0.5). Furthermore, the adsorptive performance of the PVDF/FMBO 0.5 nanofiber could be easily regenerated using diluted alkaline solution (NaOH and NaOCl).In this study, novel electrospun nanofibers composed of organic polyvinylidine fluoride and inorganic Fe–Mn binary oxide nanoparticles were fabricated using an electrospinning technique for adsorptive removal of As(v) from polluted water. 相似文献
615.
Cholestasis is associated with increased activity of the endogenous opioid system that results in analgesia. Endocannabinoid system can reduce pain sensitivity. The use of inhibitors of endocannabinoid metabolism is a novel means of pharmacologically increasing endocannabinoid levels. Considering the interaction that has been shown between the endogenous opioid and endocannabinoid systems in nociception processing, we studied the effects of URB597, a selective inhibitor of FAAH (fatty acid amide hydrolase), on modulation of nociception in a model of elevated endogenous opioid tone, cholestasis. Cholestasis was induced by ligation of the main bile duct using two ligatures and then transection of the duct at the midpoint between them. Seven days after surgery, tail-flick latencies were measured at 60 min after drug administration. A significant increase (P<0.001) in nociception threshold was observed in cholestatic rats compared to unoperated and sham groups. Administration of URB597 (0.3 mg/kg, i.p.) in cholestatic animals significantly (P<0.001) increased tail-flick latency compared to the vehicle treated cholestatic group. URB597 injection to unoperated and sham groups caused a significant (P<0.05, P<0.05) increase in tail-flick latency compared to their respective vehicle treated groups. The antinociceptive effect of URB597 was blocked by coadministration of a cannabinoid CB(1) receptor antagonist, AM251 (1 mg/kg, i.p.) but not by a cannabinoid CB(2) receptor antagonist, SR144528 (1 mg/kg, i.p.) with URB597. These data showed that URB597 as a FAAH inhibitor potentiates antinociception induced by cholestasis in tail-flick test and that the inhibitory effects of URB597 in this model are mediated by cannabinoid CB(1) and not CB(2) receptors. 相似文献
616.
617.
Seyed Mehdi Mirsaeidi Payam Tabarsi Kaveh Khoshnood Majid Valiollah Pooramiri Ali Rowhani-Rahbar Seyed Davood Mansoori Heydar Masjedi Soheyla Zahirifard Foroozan Mohammadi Parisa Farnia Mohammad Reza Masjedi Ali Akbar Velayati 《International journal of infectious diseases》2005,9(6):317-322
SETTING: Masih Daneshvari Hospital, Tehran, Iran, 2000-2002. OBJECTIVE: To evaluate the effectiveness of multiple drug-resistant tuberculosis (MDR-TB) treatment for the first time in Iran. DESIGN: All cases of MDR-TB with complete follow-up data were recruited and results of their treatments were evaluated. RESULTS: MDR-TB treatment was initiated with 5.23 drugs, on average. Isoniazid, amikacin, and ofloxacin were present in the drug regimen of all patients. Average duration of the treatment was 18.5 months (range, 7-36). Over 76% of the patients responded to the treatment (negative smear and culture). Cure and probable cure were documented in seven (41.2%) and four (23.5%) of the patients, respectively. No failure in the treatment occurred when cycloserine was present in the treatment regimen. CONCLUSION: A majority of the MDR-TB patients in Iran can be cured with the use of appropriate treatment regimens. An even greater success could be achieved by providing more second-line drugs. 相似文献
618.
Analysis of KRAS and NRAS Gene Mutations in Arab Asian Children With Acute Leukemia: High Frequency of RAS Mutations in Acute Lymphoblastic Leukemia 下载免费PDF全文
Lika'a Fasih Y. Al‐Kzayer MD PhD Kazuo Sakashita MD PhD Mazin Faisal Al‐Jadiry MD Salma Abbas Al‐Hadad MD Hasanein Habeeb Ghali MD Le T.N. Uyen MD Tingting Liu MD Kazuyuki Matsuda PhD Jaafar M.H. Abdulkadhim MD Tariq Abadi Al‐Shujairi MD Zead Ismael I.K. Matti MD Maher A. Sughayer MD Rawad Rihani MD Faris F. Madanat MD Toshi Inoshita MD Minoru Kamata MD Kenichi Koike MD PhD 《Pediatric blood & cancer》2015,62(12):2157-2161
619.
The Use of a Video Laryngoscope by Emergency Medicine Residents Is Associated With a Reduction in Esophageal Intubations in the Emergency Department 下载免费PDF全文
620.