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991.
Furuse C Tucci R Machado de Sousa SO Rodarte Carvalho Y Cavalcanti de Araújo V 《Annals of diagnostic pathology》2003,7(5):278-280
Immunohistochemistry is an important tool when dealing with salivary gland neoplasms. Canalicular adenoma and polymorphous low-grade adenocarcinoma may share some histologic characteristics that can cause difficulties in their separation. In the present study, cases of polymorphous low-grade adenocarcinoma and canalicular adenoma were submitted to a panel of antibodies to evaluate the differences in their immunoprofiles. The results obtained showed that, while vimentin is only expressed by polymorphous low-grade adenocarcinoma, CK7 and CK8 are present in both neoplasms. Therefore, vimentin is the best marker to differentiate between these tumors. 相似文献
992.
TNF‐α and IL‐10 polymorphisms increase the risk to hepatocellular carcinoma in HCV infected individuals
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Dayse Celia Aroucha Rodrigo Feliciano Carmo Luydson Richardson Silva Vasconcelos Raul Emidio Lima Taciana Furtado Mendonça Lucia Elena Arnez Maria do Socorro Mendonça Cavalcanti Maria Tereza Cartaxo Muniz Marcilio Lins Aroucha Erika Rabelo Siqueira Luciano Beltrão Pereira Patrícia Moura Leila Maria Moreira Beltrão Pereira Maria Rosangela Coêlho 《Journal of medical virology》2016,88(9):1587-1595
993.
Jeremy?R.?Beitler Ewan?C.?Goligher Matthieu?Schmidt Peter?M.?Spieth Alberto?Zanella Ignacio?Martin-Loeches Carolyn?S.?Calfee Alexandre?B.?Cavalcanti The ARDSnet Investigators 《Intensive care medicine》2016,42(5):756-767
In the last 20 years, survival among patients with acute respiratory distress syndrome (ARDS) has increased substantially with advances in lung-protective ventilation and resuscitation. Building on this success, personalizing mechanical ventilation to patient-specific physiology for enhanced lung protection will be a top research priority for the years ahead. However, the ARDS research agenda must be broader in scope. Further understanding of the heterogeneous biology, from molecular to mechanical, underlying early ARDS pathogenesis is essential to inform therapeutic discovery and tailor treatment and prevention strategies to the individual patient. The ARDSne(x)t research agenda for the next 20 years calls for bringing personalized medicine to ARDS, asking simultaneously both whether a treatment affords clinically meaningful benefit and for whom. This expanded scope necessitates standard acquisition of highly granular biological, physiological, and clinical data across studies to identify biologically distinct subgroups that may respond differently to a given intervention. Clinical trials will need to consider enrichment strategies and incorporate long-term functional outcomes. Tremendous investment in research infrastructure and global collaboration will be vital to fulfilling this agenda. 相似文献
994.
L. B. L. Maia F. S. C. Breginski T. C. S. Cavalcanti R. L. R. de Souza V. M. S. Roxo E. M. S. F. Ribeiro 《Clinical and experimental medicine》2016,16(4):593-598
The Cyclin D1 protein has been extensively studied over the last decades, for its various roles in physiological processes, both in normal and cancer cells. Gene amplifications and overexpression of CCND1 are frequently reported in several types of cancers, including breast carcinomas, showing the increasing relevance of Cyclin D1 in tumorigenesis. Little is known about the role of this protein in the metastatic process, and the main objective of this study was to evaluate the importance of the CCND1 as a potential marker of tumor progression in breast carcinomas, in a sample collected in Southern Brazil. We studied 41 samples of formalin-fixed paraffin-embedded tissue sections from invasive ductal breast carcinomas subdivided into metastatic (n = 19) and non-metastatic (n = 22) tumors. Gene expression analysis was performed through Quantitative Real-Time PCR and immunohistochemistry. In spite of the higher expression levels of CCND1 mRNA and protein in tumors when compared with the control samples, no differences were observed between the metastatic and non-metastatic groups, suggesting that, in these samples, the expression of CCND1 has no significant influence on the metastatic process. Further studies must be performed in an attempt to clarify the diagnostic and prognostic value of Cyclin D1 in breast cancers, as well as the mechanisms that trigger its overexpression in tumors. 相似文献
995.
OBJECTIVES: To validate measurement accuracy in proximity to the incisive canal from two-dimensional (2D) reformatted spiral computed tomography (CT). MATERIALS AND METHODS: Eight cadaver heads were examined with spiral CT with 1 mm thick axial slices and 1 mm.s-1 table feed. The data was transferred to a networked computer workstation to generate 2D orthoradially reformatted images. The length of the incisive canal and width of the alveolar crest were measured independently by two oral and maxillofacial radiologists. The soft tissues in the region of the incisive foramen were removed and physical measurements made using an electromagnetic digitizer. RESULTS: There was no statistically significant difference between measurements on orthoradial 2DCT images and physical measurements (P > 0.05). CONCLUSIONS: Accurate measurements for dental implant placement in proximity to the incisive canal can be made from reformatted spiral CT images. 相似文献
996.
Evaluation of maxillofacial fibrosarcoma using computer graphics and spiral computed tomography 总被引:2,自引:0,他引:2
This paper describes the appearance of three cases of maxillofacial fibrosarcoma in multiplanar (MPR) and three-dimensional reconstructed computed tomography (3DCT). The images were analysed by two oral and maxillofacial radiologists and one neuroradiologist. All of the cases clearly demonstrated the usefulness of the interactive MPR and 3DCT in the diagnosis and evaluation of the extent of these maxillofacial tumors. 相似文献
997.
Limb reduction defects in South America 总被引:1,自引:0,他引:1
998.
Costa Cde A Sena LA Pinto M Muller CA Cavalcanti JH Soares Gde A 《Brazilian dental journal》2005,16(1):75-81
This study compared in vivo the performances of commercially pure titanium (cp Ti) screw dental implants either uncoated or coated with synthetic hydroxyapatite (HA) by electrophoresis. The HA coating was characterized by scanning electron microscopy, energy dispersive spectroscopy (EDS) and Fourier-transform infrared (FT-IR) spectroscopy. Well-adhered carbonated-hydroxyapatite layers (4- to-8-microm-thick) were obtained. In vivo tests were carried out by insertion of both uncoated and HA-coated implants into rabbit tibiae for 8 or 12 weeks. Histomorphometric analysis was performed by scanning electron microscopy with the aid of image-processing software. Results showed significantly greater bone-implant contact for HA-coated implants (p<0.05) than cp Ti implants. Comparison of bone content inside the screw implants showed no significant differences (p>0.05) between both types of implants, although cp Ti had numerically higher percentage of bone content than HA-coated implants. In conclusion, the HA-coated implants had better performance regarding the bone-implant contact area than the uncoated implants; coating by electrophoresis proved to be a valuable process to coat metallic implants with an osteoconductive material such as hydroxyapatite. 相似文献
999.
Campos MS Cavalcanti BN Cunha VP 《The European journal of prosthodontics and restorative dentistry》2005,13(2):78-80
Ten pairs of stone casts were mounted in an articulator using a standardized maxillomandibular relation, on which trial dentures were constructed. Two groups were established: GI- pack-and-press technique; GII- injection-pressing technique. Intermaxillar contacts were marked and counted, and the contact between incisal pin and incisal table was measured, before and after the processing. The average contact loss after the processing was 37.85% (GI) and 20.8% (GII). The average incisal pin opening after the processing was 1.3mm (GI) and 0 (GII). Data differed statistically (Mann-Whitney's test, p < 0.05). The injection-pressing system was superior according to contact loss and incisal pin opening. 相似文献
1000.
da Silva MJ de Sousa SO Corrêa L Carvalhosa AA De Araújo VC 《Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics》2002,94(6):732-737
OBJECTIVE: Orthokeratinized odontogenic cyst (OOC) is a developmental cyst that occurs in the maxilla and the mandible and is defined by the World Health Organization as the uncommon orthokeratinized type of odontogenic keratocyst (OKC). However, studies have shown that OOC has peculiar clinicopathologic aspects and biologic behavior when compared with other developmental odontogenic cysts, especially OKCs. Therefore, in this study, the immunohistochemical profile of the OOC was delineated and compared with that of the OKC. STUDY DESIGN: Twelve cases of OOC were submitted to a panel of antibodies composed of cytokeratins (10, 13, and 14) and extracellular matrix proteins: fibronectin, types I and III collagen, and tenascin. For comparative means, 12 cases of OKC also were submitted to the same panel of antibodies. RESULTS: The results obtained showed that OOCs expressed cytokeratin 10 and showed variable expression of cytokeratins 13 and 14. Fibronectin and collagen types I and III also were expressed in OOC in a fibrillar aspect. OKC showed only the superficial keratin layer positive to cytokeratin 10 and the basal and suprabasal layers with variable expression of cytokeratin 14, and cytokeratin 13 was present in the upper epithelial layers. The extracellular matrix proteins showed a nonfibrillar expression. Tenascin was immunoexpressed only in OKC. CONCLUSION: The immunohistochemical profile of the studied cysts clearly showed that OOC presents a well-formed cystic enveloping, whereas the OKC profile is compatible with a more aggressive biologic behavior. 相似文献