全文获取类型
收费全文 | 269篇 |
免费 | 32篇 |
国内免费 | 3篇 |
专业分类
耳鼻咽喉 | 1篇 |
儿科学 | 7篇 |
妇产科学 | 5篇 |
基础医学 | 49篇 |
口腔科学 | 1篇 |
临床医学 | 29篇 |
内科学 | 104篇 |
皮肤病学 | 5篇 |
神经病学 | 31篇 |
特种医学 | 5篇 |
外科学 | 23篇 |
综合类 | 2篇 |
预防医学 | 15篇 |
眼科学 | 4篇 |
药学 | 20篇 |
肿瘤学 | 3篇 |
出版年
2023年 | 14篇 |
2022年 | 4篇 |
2021年 | 6篇 |
2020年 | 2篇 |
2019年 | 5篇 |
2018年 | 11篇 |
2017年 | 8篇 |
2016年 | 11篇 |
2015年 | 7篇 |
2014年 | 6篇 |
2013年 | 20篇 |
2012年 | 16篇 |
2011年 | 12篇 |
2010年 | 12篇 |
2009年 | 8篇 |
2008年 | 8篇 |
2007年 | 13篇 |
2006年 | 21篇 |
2005年 | 9篇 |
2004年 | 6篇 |
2003年 | 14篇 |
2002年 | 8篇 |
2001年 | 3篇 |
2000年 | 3篇 |
1999年 | 3篇 |
1998年 | 5篇 |
1997年 | 7篇 |
1996年 | 4篇 |
1995年 | 6篇 |
1993年 | 2篇 |
1992年 | 3篇 |
1991年 | 3篇 |
1990年 | 3篇 |
1989年 | 3篇 |
1988年 | 6篇 |
1985年 | 2篇 |
1982年 | 3篇 |
1980年 | 2篇 |
1978年 | 2篇 |
1977年 | 3篇 |
1976年 | 2篇 |
1975年 | 1篇 |
1969年 | 1篇 |
1961年 | 1篇 |
1959年 | 1篇 |
1957年 | 1篇 |
1956年 | 1篇 |
1955年 | 2篇 |
1954年 | 3篇 |
1949年 | 2篇 |
排序方式: 共有304条查询结果,搜索用时 15 毫秒
51.
52.
Bergthorsson JT Agnarsson BA Gudbjartsson T Magnusson K Thoroddsen A Palsson B Bjornsson J Stefansson K Gulcher J Einarsson GV Amundadottir LT Barkardottir RB 《Cancer Genetics and Cytogenetics》2006,164(1):1-9
Testicular germ cell tumors (TGCT) arise by multistep carcinogenesis pathways involving selective losses and gains of chromosome material. To locate cancer genes underlying this selection, we performed a genome-wide study of allelic imbalance (AI) in 32 tumors, using 710 microsatellite markers. The highest prevalence of AI was found at 12p, in line with previous studies finding consistent gain of the region in TGCTs. High frequency of AI was also observed at chromosome arms 4p, 9q, 10p, 11q, 11p, 13q, 16q, 18p, and 22q. Within 39 candidate regions identified by mapping of smallest regions of overlap (SROs), the highest frequency of AI was at 12p11.21 approximately p11.22 (62%), 12p12.1 approximately p13.1 (53%), 12p13.1 approximately p13.2 (53%), 11q14.1 approximately q14.2 (53%), 11p13 approximately p14.3 (47%), 9q21.13 approximately q21.32 (47%), and 4p15.1 approximately p15.2 (44%). Two genes known to be involved in cancer reside in these regions, ETV6 at 12p13.2 (TEL oncogene) and WT1 at 11p13. We also found a significant association (P = 0.02) between AI at 10q21.1 approximately q22.2 and higher clinical stage. This study contributes to the ongoing search for genes involved in transformation of germ cells and provides a useful reference point to previous studies using cytogenetic techniques to map chromosome changes in TGCTs. 相似文献
53.
54.
55.
Hafdis Helgadottir Birna Thorisdottir Ingibjorg Gunnarsdottir Thorhallur I. Halldorsson Gestur Palsson Inga Thorsdottir 《Nutrients》2022,14(3)
To strengthen the organization of new national dietary surveys and interventions in childhood, our aim was to study macronutrient intake and blood lipid profile at 6 years of age by comparing results from two earlier population-based cohorts. Subjects were n = 131 and n = 162 in the years 2001–2002 and 2011–2012, respectively. Three-day weighed food records were used to estimate diet and calculate nutrient intake. Total cholesterol, HDL-cholesterol and triacylglycerol were measured in serum and LDL-cholesterol was calculated. The average intake of saturated fatty acids (SFA) and trans FA was lower in 2011–2012 than 2001–2002 (13.3E% vs. 14.7E%, p < 0.001, and 0.8E% vs. 1.4E%, p < 0.001, respectively), replaced by a higher intake of unsaturated fatty acids. Total cholesterol and LDL-cholesterol were significantly lower in 2011–2012 than 2001–2002 (4.6 vs. 4.4 mmol/L, p = 0.003 and 2.8 vs. 2.5 mmol/L, p < 0.001, respectively). In a multiple linear regression model, one E% increase in SFA intake was related to a 0.03 mmol/L increase in LDL cholesterol (p = 0.04). A lower intake of saturated and trans fatty acids, replaced by unsaturated fatty acids, may have contributed to an improved lipid profile in a healthy 6-year-old population. Biological data for analysis of blood lipids are important in national dietary surveys in healthy children to monitor important health outcomes of interventions. 相似文献
56.
57.
Giuseppe Chiarioni Olafur S Palsson Corrado R Asteria William E Whitehead 《World journal of gastroenterology : WJG》2013,19(41):7048-7054
Fecal incontinence is a disabling symptom with medical and social implications,including fear,embarrassment,isolation and even depression.Most patients live in seclusion and have to plan their life around the symptom,with secondary impairment of their quality of life.Conservative management and biofeedback therapy are reported to benefit a good percentage of those affected.However,surgery must be considered in the nonresponder population.Recently,sacral nerve electrostimulation,lately named neuromodulation,has been reported to benefit patients with fecal incontinence in randomized controlled trials more than placebo stimulation and conservative management,by some unknown mechanism.Neuromodulation is a minimally invasive procedure with a low rate of adverse events and apparently favorable cost-efficacy profile.This review is intended to expand knowledge about this effective intervention among the non-surgically skilled community who deals with this disabled group of patients. 相似文献
58.
Shin Fukudo Kumi Nakaya Tomohiko Muratsubaki Naoki Nakaya Atsushi Hozawa Shrikant I. Bangdiwala Olafur S. Palsson Ami D. Sperber Motoyori Kanazawa 《Neurogastroenterology and motility》2023,35(6):e14581
Background
The aims were to use Japanese data from the Rome Foundation Global Epidemiological Study (RFGES) to test the hypotheses that severity of gastrointestinal (GI) symptoms and psychosocial disturbance are ordered as Rome IV irritable bowel syndrome (IBS) > Rome III IBS > DGBI, not IBS > others.Methods
Subjects were 2504 Japanese in the RFGES. We assessed DGBI/IBS diagnoses with Rome IV/III, IBS Symptom Severity Scale (IBS-SSS), Patient Health Questionnaire (PHQ) for anxiety/depression and non-GI somatic symptoms, PROMIS-10 for quality of life (QOL), Work Productivity and Activity Impairment (WPAI) Questionnaire, parts of Self-reported IBS Questionnaire (SIBSQ) for meal effect and stress effect, Food Frequency Questionnaire, and medication questions.Key Results
The prevalence of Rome IV DGBI was as follows; IBS-C 0.5%, IBS-D 0.8%, IBS-M 0.8%, IBS-U 0.1%, unspecified functional bowel disorder 10.7%, postprandial distress syndrome 2.2%, and epigastric pain syndrome 0.3%. Rome III IBS prevalence; IBS-C 3.0%, IBS-D 3.1%, IBS-M 2.7%, and IBS-U 0.6%. Comparison among Rome IV IBS (n = 54), Rome III IBS (n = 197), other DGBI (n = 746), others (n = 1389) revealed significant order as Rome IV IBS > Rome III IBS > other DGBI > others in IBS-SSS, anxiety/depression, activity impairment, non-GI symptoms, physical QOL, mental QOL, exacerbated symptoms by meals and perceived stress (all p < 0.001).Conclusions & Inferences
These findings support the study hypotheses. Data from Japan as a culturally homogenous country suggest Rome IV IBS is more severe and hence has more gut–brain psychobehavioral involvement than Rome III IBS. 相似文献59.
Bert Broeders Elise Devolder Michael Jones Magnus Simrén Shrikant I. Bangdiwala Ami D. Sperber Olafur S. Palsson Jan Tack 《Neurogastroenterology and motility》2023,35(6):e14588
Background
The Rome Foundation carried out a worldwide epidemiology study on DGBI according to the Rome IV criteria in 33 countries, including Belgium. DGBI prevalence varied between continents and countries, but prevalence differences within language groups in a single country have not yet been described.Methods
We analyzed the prevalence rates of 18 DGBI and their psychosocial impact in Belgium in the French and Dutch language groups.Key Results
DGBI prevalence was similar in the French-speaking and Dutch-speaking population. Having one or more DGBI was negatively associated with psychosocial well-being. The scores for depression were lower in the Dutch-speaking participants with one or more DGBI compared to the French-speaking participants. Interestingly, we also found significantly lower scores in the general Dutch-speaking versus the French-speaking population for depression and non-gastrointesinal somatic symptoms, and higher global physical health and mental health quality-of-life component scores. In the Dutch-speaking group, medication use for gastric acid was lower, but use of prescribed analgesics was more common. Nevertheless, the use of non-prescribed pain medication was higher in the French-speaking group. Anxiety and sleep medication use was also higher in the latter group.Conclusions & Interferences
The results of this first in-depth analysis of Rome IV DGBI in Belgium show a higher prevalence for some DGBI in the French-speaking cohort, and a larger associated disease burden. These differences between language/culture groups in the same country support the psychosocial pathophysiological model of DGBI. 相似文献60.
Johann P. Hreinsson Reuben K. M. Wong Jan Tack Peter Whorwell Marc A. Benninga Viola Andresen Bruno Bonaz Suck Chei Choi Enrico S. Corazziari Javier Santos Shin Fukudo Motoyori Kanazawa Xuicai Fang Shrikant I. Bangdiwala Ami D. Sperber Olafur S. Palsson Magnus Simrén 《Neurogastroenterology and motility》2023,35(6):e14566